Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sheona Watson"'
Autor:
Kourtney Sloan, Jared Thomas, Matthew Blackwell, Deanna Voisard, Eva Lana-Elola, Sheona Watson-Scales, Daniel L. Roper, Joseph M. Wallace, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Randall J. Roper
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/3bbbbb9016c543a4b1f805a022884fdf
Autor:
Eva Lana-Elola, Heather Cater, Sheona Watson-Scales, Simon Greenaway, Jennifer Müller-Winkler, Dorota Gibbins, Mihaela Nemes, Amy Slender, Tertius Hough, Piia Keskivali-Bond, Cheryl L. Scudamore, Eleanor Herbert, Gareth T. Banks, Helene Mobbs, Tara Canonica, Justin Tosh, Suzanna Noy, Miriam Llorian, Patrick M. Nolan, Julian L. Griffin, Mark Good, Michelle Simon, Ann-Marie Mallon, Sara Wells, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 10 (2021)
Down syndrome (DS), trisomy 21, results in many complex phenotypes including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from an extra copy of human chromosome 21 (Hsa21) genes. However, these dosage-sensitive cau
Externí odkaz:
https://doaj.org/article/2e0de4e621364f88bbb0ae2f68e17fe9
Autor:
Helena Ahlfors, Nneka Anyanwu, Edvinas Pakanavicius, Natalia Dinischiotu, Eva Lana-Elola, Sheona Watson-Scales, Justin Tosh, Frances Wiseman, James Briscoe, Karen Page, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Gene expression dysregulation domains (GEDDs) have been reported in Down syndrome (DS) cells, where changes in gene expression are clustered. Here the authors find that, while GEDDs are present in DS cells and in the Dp1Tyb mouse model of DS, GEDDs d
Externí odkaz:
https://doaj.org/article/d58c59e260be485db688012547887273
Autor:
Eva Lana-Elola, Sheona Watson-Scales, Amy Slender, Dorota Gibbins, Alexandrine Martineau, Charlotte Douglas, Timothy Mohun, Elizabeth MC Fisher, Victor LJ Tybulewicz
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/2da0d7a93f7d4b9ebaaaf777cd4c2973
Autor:
Alain D. Dekker, Yannick Vermeiren, Christelle Albac, Eva Lana-Elola, Sheona Watson-Scales, Dorota Gibbins, Tony Aerts, Debby Van Dam, Elizabeth M.C. Fisher, Victor L.J. Tybulewicz, Marie-Claude Potier, Peter P. De Deyn
Publikováno v:
Neurobiology of Disease, Vol 105, Iss , Pp 235-244 (2017)
Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in people with Down syndrome (DS, trisomy 21). Because of the limited availability of human post-mortem tissue, DS mouse models are of great interest to
Externí odkaz:
https://doaj.org/article/cd6d4a7b4bcd47e9b878a2463ab19abb
Autor:
Sheona Watson-Scales, Bernadett Kalmar, Eva Lana-Elola, Dorota Gibbins, Federica La Russa, Frances Wiseman, Matthew Williamson, Rachele Saccon, Amy Slender, Anna Olerinyova, Radma Mahmood, Emma Nye, Heather Cater, Sara Wells, Y Eugene Yu, David L H Bennett, Linda Greensmith, Elizabeth M C Fisher, Victor L J Tybulewicz
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007383 (2018)
Down Syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and results in a spectrum of phenotypes including learning and memory deficits, and motor dysfunction. It has been hypothesized that an additional copy of a few Hsa21 dosage-sensitive g
Externí odkaz:
https://doaj.org/article/cf34bed66d614aab8625e9cbd15f2434
Autor:
Eva Lana-Elola, Sheona Watson-Scales, Amy Slender, Dorota Gibbins, Alexandrine Martineau, Charlotte Douglas, Timothy Mohun, Elizabeth MC Fisher, Victor LJ Tybulewicz
Publikováno v:
eLife, Vol 5 (2016)
Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is the most common cause of congenital heart defects (CHD), yet the genetic and mechanistic causes of these defects remain unknown. To identify dosage-sensitive genes that cause DS
Externí odkaz:
https://doaj.org/article/4fe82290905a491088604912fc14ed59
Autor:
Matilda A Haas, Donald Bell, Amy Slender, Eva Lana-Elola, Sheona Watson-Scales, Elizabeth M C Fisher, Victor L J Tybulewicz, François Guillemot
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78561 (2013)
Down Syndrome (DS) is a highly prevalent developmental disorder, affecting 1/700 births. Intellectual disability, which affects learning and memory, is present in all cases and is reflected by below average IQ. We sought to determine whether defectiv
Externí odkaz:
https://doaj.org/article/00a01fc3c0604f25ad08c228f3de7c70
Autor:
Yushi Redhead, Dorota Gibbins, Eva Lana-Elola, Sheona Watson-Scales, Lisa Dobson, Matthias Krause, Karen J. Liu, Elizabeth M. C. Fisher, Jeremy B. A. Green, Victor L. J. Tybulewicz
Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), occurs in 1 in 800 live births and is the most common human aneuploidy. DS results in multiple phenotypes, including craniofacial dysmorphology, characterised by midfacial hypoplasia, brachy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d76f47713c86f47026957f902ae77c5
Autor:
Sheona Watson-Scales, Elizabeth M. C. Fisher, Timothy J. Mohun, Victor L. J. Tybulewicz, Eva Lana-Elola, Charlotte Douglas, Alexandrine Martineau, Amy Slender, Dorota Gibbins
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206a8b72296ea2e22bc02fe7dc887d17
https://elifesciences.org/articles/61021
https://elifesciences.org/articles/61021