Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Sheo B Singh"'
Autor:
Sheo B Singh, Ling Kang, Andrea R Nawrocki, Dan Zhou, Margaret Wu, Stephen Previs, Corey Miller, Haiying Liu, Catherine D G Hines, Maria Madeira, Jin Cao, Kithsiri Herath, Larry D Spears, Clay F Semenkovich, Liangsu Wang, David E Kelley, Cai Li, Hong-Ping Guan
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170721 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0164133.].
Externí odkaz:
https://doaj.org/article/a0c42ee3102d4affbbde67b225f02f09
Autor:
Sheo B Singh, Ling Kang, Andrea R Nawrocki, Dan Zhou, Margaret Wu, Stephen Previs, Corey Miller, Haiying Liu, Catherine D G Hines, Maria Madeira, Jin Cao, Kithsiri Herath, Larry D Spears, Clay F Semenkovich, Liangsu Wang, David E Kelley, Cai Li, Hong-Ping Guan
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164133 (2016)
Platensimycin (PTM) is a natural antibiotic produced by Streptomyces platensis that selectively inhibits bacterial and mammalian fatty acid synthase (FAS) without affecting synthesis of other lipids. Recently, we reported that oral administration of
Externí odkaz:
https://doaj.org/article/09d9a7eab4db484ba8f12a3152bad96d
Autor:
Sheo B. Singh, Lynn Miesel, Susanne Kramer, Libo Xu, Fangbio Li, Jing Lan, Phillip Lipari, Jon D. Polishook, Gongjie Liu, Lianzhu Liang, Amy M. Flattery
Publikováno v:
Journal of Natural Products. 85:1141-1146
Autor:
Kithsiri Herath, Athula B. Attygalle, Sheo B. Singh, Olga Genilloud, Thomas P. Roddy, Stephen F. Previs, Ignacio González
Publikováno v:
Journal of Natural Products. 84:814-823
Natural product congeners serve a useful role in the understanding of natural product biosynthesis and structure-activity relationships. A minor congener with superior activity, selectivity, and modifiable functional groups could serve as a more effe
Autor:
Sheo B. Singh, Christopher M. Tan, David Kaelin, Peter T. Meinke, Lynn Miesel, David B. Olsen, Hideyuki Fukuda, Ryuta Kishii, Masaya Takei, Kohei Ohata, Tomoko Takeuchi, Taku Shibue, Hisashi Takano, Akinori Nishimura, Yasumichi Fukuda
Publikováno v:
Bioorganicmedicinal chemistry letters. 75
Novel bacterial topoisomerase inhibitors (NBTIs) are the newest members of gyrase inhibitor broad-spectrum antibacterial agents, represented by the most advanced member, gepotidacin, a 4-amino-piperidine linked NBTI, which is undergoing phase III cli
Autor:
Thomas P. Roddy, Gowri Bhat, Kithsiri Herath, Ling Kang, Sheo B. Singh, Stacey Conarello, Deborah Slipetz, David E. Kelley, Carlos G. Rodriguez, Andrea R. Nawrocki, Mark D. Erion, Stephen F. Previs, Jenna L. Terebetski
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 315:E63-E71
An increased contribution of de novo lipogenesis (DNL) may play a role in cases of dyslipidemia and adipose accretion; this suggests that inhibition of fatty acid synthesis may affect clinical phenotypes. Since it is not clear whether modulation of o
Publikováno v:
Biochemical Pharmacology. 133:63-73
An ideal antibiotic is an antibacterial agent that kills or inhibits the growth of all harmful bacteria in a host, regardless of site of infection without affecting beneficial gut microbes (gut flora) or causing undue toxicity to the host. Sadly, no
Autor:
Libo Xu, Natalia Kurepina, Barry N. Kreiswirth, Peter T. Meinke, Katherine Young, David B. Olsen, Sheo B. Singh
Publikováno v:
The Journal of Antibiotics. 70:671-674
Thiazolyl peptides are a class of natural products with potent Gram-positive antibacterial activities. Lack of aqueous solubility precluded this class of compounds from advancing to clinical evaluations. Nocathiacins and thiazomycins are sub-classes
Autor:
Jingjun Yin, Kouhei Oohata, Peter T. Meinke, Armando Lagrutta, David E. Kaelin, Lynn Miesel, Charles Gill, Hideyuki Fukuda, Charles G. Garlisi, Sheo B. Singh, Yasumichi Fukuda, Christopher M. Tan, Toussaint Nathalie Y, Taku Shibue, Tomoko Takeuchi, Hisashi Takano, Ryuta Kishii, Masaya Takei, David B. Olsen, Akinori Nishimura, Jin Wu, Takayuki Tsuchiya
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:4830-4839
Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors (NBTIs) represent a new class of recently described antibacterial agents with broad-spectrum activity. NBTIs dually inhibit the clinically validated bacterial targets DNA gyrase and top
Autor:
Tanya Parish, David B. Olsen, Mai A. Bailey, Aaron Korkegian, Katherine Young, Theresa O’Malley, Bjorn Sunde, Sheo B. Singh, Yulia Ovechkina, James C. Sacchettini, Thomas R. Ioerger, Joshua Odingo
Publikováno v:
BMC Research Notes
BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018)
BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018)
Objective Our aim was to identify natural products with anti-tubercular activity. Results A set of ~ 500 purified natural product compounds was screened for inhibition against the human pathogen Mycobacterium tuberculosis. A series of cyclic hexapept