Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Shenyu Zhai"'
Autor:
Shenyu Zhai, Shintaro Otsuka, Jian Xu, Vernon R.J. Clarke, Tatiana Tkatch, David Wokosin, Zhong Xie, Asami Tanimura, Hitesh K. Agarwal, Graham C.R. Ellis-Davies, Anis Contractor, D. James Surmeier
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114540- (2024)
Summary: Long-term synaptic plasticity at glutamatergic synapses on striatal spiny projection neurons (SPNs) is central to learning goal-directed behaviors and habits. Our studies reveal that SPNs manifest a heterosynaptic, nitric oxide (NO)-dependen
Externí odkaz:
https://doaj.org/article/64e2bb0353c840138c166c68e3cd5c2c
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 15 (2023)
For roughly the last 30 years, the notion that striatal dopamine (DA) depletion was the critical determinant of network pathophysiology underlying the motor symptoms of Parkinson’s disease (PD) has dominated the field. While the basal ganglia circu
Externí odkaz:
https://doaj.org/article/bbdb653a6efc44e5a62689955b8b537a
Publikováno v:
Neurobiology of Disease, Vol 167, Iss , Pp 105686- (2022)
The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate acquisition and vigor of goal-directed actions and habits. This innervation is progressively lost in Parkinson's disease (PD), contributing to the defining movemen
Externí odkaz:
https://doaj.org/article/a19e1a640e7044e0a84def388665bc8d
Autor:
Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguière, Morgane Thomsen, Hui Zhang, Cinzia Costa, Giuseppina Martella, Veronica Ghiglieri, Barbara Picconi, Karen A. Pescatore, Ellen M. Unterwald, Walker S. Jackson, David E. Housman, S. Barak Caine, David Sulzer, Paolo Calabresi, Anne C. Smith, D. James Surmeier, Ann M. Graybiel
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105473- (2021)
CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntington's disease and l
Externí odkaz:
https://doaj.org/article/dcb665d27eb248cbbbad7e35d7e418a7
Autor:
Igor V. Rafalovich, Alexandria E. Melendez, Joshua L. Plotkin, Asami Tanimura, Shenyu Zhai, D. James Surmeier
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1336-1342 (2015)
Experience-driven plasticity of glutamatergic synapses on striatal spiny projection neurons (SPNs) is thought to be essential to goal-directed behavior and habit formation. One major form of striatal plasticity, long-term depression (LTD), has long a
Externí odkaz:
https://doaj.org/article/afa82e5a1ec64e93bffffd647f24f024
Autor:
Xin Zhao, Shenyu Zhai, Ming-Sheng An, Yue-Hua Wang, Ying-Fan Yang, Hui-Qi Ge, Jin-Hao Liu, Xiao-Ping Pu
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78220 (2013)
Protocatechuic aldehyde (PAL) has been reported to bind to DJ-1, a key protein involved in Parkinson's disease (PD), and exerts potential neuroprotective effects via DJ-1 in SH-SY5Y cells. In this study, we investigated the neuroprotective pharmacolo
Externí odkaz:
https://doaj.org/article/e1950e3882f448cea9342992c35e8b92
Publikováno v:
Frontiers in Synaptic Neuroscience; 2023, p1-10, 10p
Publikováno v:
Neurobiology of disease. 167
The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate acquisition and vigor of goal-directed actions and habits. This innervation is progressively lost in Parkinson's disease (PD), contributing to the defining movemen
Autor:
Shenyu Zhai
Publikováno v:
J Neurosci
Despite extensive research into understanding synaptic mechanisms of striatal plasticity, the functional role played by astrocytes in this region remains to be fully elucidated. It was recently demonstrated that high-frequency stimulation (HFS) of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457c81626921ee198cf5d2a37fab1674
https://europepmc.org/articles/PMC8018762/
https://europepmc.org/articles/PMC8018762/
Autor:
Weixing Shen, Alfred L. George, D. James Surmeier, Ananya Mitra, Carlos G. Vanoye, Wenjie Ren, Ben Yang, Shenyu Zhai
Publikováno v:
J Clin Invest
Levodopa-induced dyskinesia (LID) poses a significant health care challenge for Parkinson’s disease (PD) patients. Amantadine is currently the only drug proven to alleviate LID. Although its efficacy in treating LID is widely assumed to be mediated