Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shenye Hu"'
Publikováno v:
Crystal Growth & Design. 20:2057-2063
Two new salts of ligustrazine (tetramethylpyrazine, TMP) with the sweeteners, saccharine (SAC) and acesulfame (ACS), have been synthesized through the anion exchange reaction. Single crystals of the new forms were prepared, and their structures were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::593fe92b3e16ed82bea7e21897ca698a
https://doi.org/10.1021/acs.cgd.9b01704
https://doi.org/10.1021/acs.cgd.9b01704
Publikováno v:
Chemistry of Materials. 31:3818-3822
We report here the first pharmaceutical twistable hydrogen-bonded two-dimensional plastic hydrate crystal of a well-known psychoactive drug, caffeine (CAH). The availability of two pairs of plastic...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc2931057187d950817e480c40164d75
https://doi.org/10.1021/acs.chemmater.9b00441
https://doi.org/10.1021/acs.chemmater.9b00441
Autor:
Albert Hee Lum Chow, Wai Yip Thomas Lee, Shenye Hu, Xiaoyan Xu, Wai Wing Ng, Si Nga Wong, Shing Fung Chow, Ka Lun Lai, Changquan Calvin Sun
Publikováno v:
Crystal Growth & Design. 18:5534-5546
Recent advances in crystal engineering by cocrystallization have offered a promising approach for tackling undesirable physicochemical properties of drug substances. In this study, various structur...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2af8dc59a88fb5958d3d38868ee8261b
https://doi.org/10.1021/acs.cgd.8b00849
https://doi.org/10.1021/acs.cgd.8b00849
Publikováno v:
Crystal Growth & Design. 17:6030-6040
Clear understanding of the relationships among crystal structure, mechanical properties, and tableting performance is of enormous importance for successful development of tablet products. This study was aimed at systematically examining such relation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17346f421188a4df4c06db311f6f23f7
https://doi.org/10.1021/acs.cgd.7b01153
https://doi.org/10.1021/acs.cgd.7b01153
Publikováno v:
International journal of pharmaceutics. 577
Ligustrazine (or Tetramethylpyrazine, TMP) is an active pharmaceutical ingredient that faces the challenges of bitter taste and low oral bioavailability by the commercial phosphate salt (TMP-Pho). We tackled these challenges by forming salts with two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa10203cbe6344accc53bba26b9323a4
https://pubmed.ncbi.nlm.nih.gov/32001292
https://pubmed.ncbi.nlm.nih.gov/32001292
Autor:
Yuhui, Li, Junguang, Yu, Shenye, Hu, Zhenxuan, Chen, Mark, Sacchetti, Changquan Calvin, Sun, Lian, Yu
Publikováno v:
Molecular Pharmaceutics
As a result of its higher molecular mobility, the surface of an amorphous drug can grow crystals much more rapidly than the bulk, causing poor stability and slow dissolution of drug products. We show that a nanocoating of chitosan (a pharmaceutically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f59ed9c1cb1b83a18abffcff0b05598b
https://pubmed.ncbi.nlm.nih.gov/30668120
https://pubmed.ncbi.nlm.nih.gov/30668120
Publikováno v:
Crystal Growth & Design. 16:5030-5039
Highly soluble cocrystals can be used to improve bioavailability of a poorly soluble drug, through generating supersaturation, when absorption is limited by drug dissolution. Dihydromyricetin (DMY) is a biopharmaceutics classification system (BCS) IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::060389c086a4d421d2abe1bf4599513c
https://doi.org/10.1021/acs.cgd.6b00591
https://doi.org/10.1021/acs.cgd.6b00591
Publikováno v:
Molecular pharmaceutics. 14(10)
A palatable direct compression (DC) orally disintegrating tablet (ODT) product of a bitter drug, diphenhydramine (DPH), was developed using an integrated crystal and particle engineering approach. A DPH salt with a sweetener, acesulfame (Acs), DPH-Ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7447fb5bd815d8a9801635dd73d3f73e
https://pubmed.ncbi.nlm.nih.gov/28825961
https://pubmed.ncbi.nlm.nih.gov/28825961
Publikováno v:
International journal of pharmaceutics. 532(1)
Salt formation has been extensively used to improve drug properties, including solubility, stability and mechanical properties. A sweet salt of metformin with acesulfame, prepared though an anion exchange reaction, showed superior properties over the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d73bbb9d6af60ba09d2a213c5183019
https://pubmed.ncbi.nlm.nih.gov/28844896
https://pubmed.ncbi.nlm.nih.gov/28844896
Publikováno v:
Crystal Growth & Design; Nov2017, Vol. 17 Issue 11, p6030-6040, 11p