Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shenxin Zeng"'
Autor:
ZunyuanWang, ShuWang, Jiazhe Chai, Xinglong Chi, Jiaxun Ying, Youkun Kang, Youlu Pan, Shenxin Zeng, Zhen Ma, Wenyong Wang, Wenhai Huang
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 9, Pp 105906- (2024)
Bruton’s tyrosine kinase (BTK) is a key protein in B cell antigen receptor (BCR) signaling pathway, and is a research hotspot in the clinical treatment of B cell tumors and B cell immune diseases. In this article, based on the structure of Ibrutini
Externí odkaz:
https://doaj.org/article/f3346b46919b40abada885af61fe9f3b
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Hepatitis B virus infections have always been associated with high levels of mortality. In 2019, hepatitis B virus (HBV)-related diseases resulted in approximately 555,000 deaths globally. In view of its high lethality, the treatment of HBV infection
Externí odkaz:
https://doaj.org/article/36cc5f3ff18540a299a8a0782ac5d8e8
Autor:
Zhimin Zhang, Xinyue Chang, Chixiao Zhang, Shenxin Zeng, Meihao Liang, Zhen Ma, Zunyuan Wang, Wenhai Huang, Zhengrong Shen
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1606-1615 (2020)
Poly(ADP-ribose) polymerase-1 (PARP-1), a critical DNA repair enzyme in the base excision repair pathway, has been pursued as an attractive cancer therapeutic target. Intervention with PARP-1 has been proved to be more sensitive to cancer cells carry
Externí odkaz:
https://doaj.org/article/7a93c6b4612e48189e7b560a91de485e
Autor:
Zhimin Zhang, Lili Gu, Beibei Wang, Wenhai Huang, Yanmin Zhang, Zhen Ma, Shenxin Zeng, Zhengrong Shen
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 808-817 (2019)
The bromodomain and extra-terminal (BET) bromodomains, particularly BRD4, have been identified as promising therapeutic targets in the treatment of many human disorders such as cancer, inflammation, obesity, and cardiovascular disease. Recently, the
Externí odkaz:
https://doaj.org/article/4995ee9b8fb84c74b8584b53503efc78
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Photopharmacology is an emerging field that uses light to precisely control drug activity. This strategy promises to improve drug specificity for reducing off-target effects. Proteolysis-targeting chimeras (PROTACs) are an advanced technology enginee
Externí odkaz:
https://doaj.org/article/5ece9afbdda4471080f3e6e733a7be1c
Autor:
Meihao, Liang, Lili, Gu, Hongjie, Zhang, Jingli, Min, Zunyuan, Wang, Zhen, Ma, Chixiao, Zhang, Shenxin, Zeng, Youlu, Pan, Dongmei, Yan, Zhengrong, Shen, Wenhai, Huang
Publikováno v:
ACS Omega. 7:26308-26315
The abnormal phosphorylation of the τ-protein is a typical early pathological feature of Alzheimer's disease (AD). The excessive phosphorylation of the τ-protein in the brain causes the formation of neurofibrillary tangles (NFTs) and increases the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be634388da5235f8def56b1304f40d1
https://doi.org/10.1021/acsomega.2c02130
https://doi.org/10.1021/acsomega.2c02130
Autor:
Jingyu Zhang, Jinxin Che, Xiaomin Luo, Mingfei Wu, Weijuan Kan, Yuheng Jin, Hanlin Wang, Ao Pang, Cong Li, Wenhai Huang, Shenxin Zeng, Weihao Zhuang, Yizhe Wu, Yongjin Xu, Yubo Zhou, Jia Li, Xiaowu Dong
Publikováno v:
Journal of Medicinal Chemistry. 65:9096-9125
Bruton's tyrosine kinase proteolysis-targeting chimeras (BTK-PROTACs) have emerged as a promising approach to address the limitations of BTK inhibitors. However, conducting the rational discovery of orally bioavailable BTK-PROTACs presents significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f7eeec2b828f4b434d5079501c79a1
https://doi.org/10.1021/acs.jmedchem.2c00324
https://doi.org/10.1021/acs.jmedchem.2c00324
Publikováno v:
RSC Advances. 11:3003-3011
An efficient and practical benzylic aerobic oxidation catalyzed by cheap and simple N-hydroxyimide organocatalyst has been achieved with high yields and broad substrate scope. The organocatalyst used can be recycled and reused by simple workup and on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce1a3b4e31553251ce2d101b77bb1617
https://doi.org/10.1039/d0ra10475b
https://doi.org/10.1039/d0ra10475b
Autor:
Wenhai Huang, Zhengrong Shen, Xinyue Chang, Shenxin Zeng, Zhimin Zhang, Ma Zhen, Wang Zunyuan, Liang Meihao, Zhang Chixiao
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1606-1615 (2020)
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1606-1615 (2020)
Poly(ADP-ribose) polymerase-1 (PARP-1), a critical DNA repair enzyme in the base excision repair pathway, has been pursued as an attractive cancer therapeutic target. Intervention with PARP-1 has been proved to be more sensitive to cancer cells carry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514c9d19e53dcd01fb4229288558c914
http://europepmc.org/articles/PMC7470090
http://europepmc.org/articles/PMC7470090
Autor:
Youlu Pan, Xiaomeng Gong, Rongrong Hao, Shenxin Zeng, Jinghao Xu, Zhengrong Shen, Wenhai Huang
Publikováno v:
Asian Journal of Organic Chemistry. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd2c63ce3d35e23d8158d4871b2af157
https://doi.org/10.1002/ajoc.202100766
https://doi.org/10.1002/ajoc.202100766