CD3 ⁺ TCRαβ/CD19 ⁺ -depleted stem cell boost and CD45RO ⁺ memory T-cell add-back as a successful salvage treatment for poor graft function unresponsive to eltrombopag, following a second allogenic HSCT.

Autor: Ramanathan S; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Department of Paediatric and Adolescent Haematology and Oncology, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Roberts W; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Department of Paediatric and Adolescent Haematology and Oncology, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Nademi Z; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Shenton G; Department of Paediatric and Adolescent Haematology and Oncology, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Watson H; Blood Sciences, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, UK., Matthews E; Newcastle Advanced Therapies, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, UK., Carruthers K; Newcastle Advanced Therapies, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, UK., Gennery AR; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Hambleton S; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Slatter M; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Lum SH; Department of Paediatric Haematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Publikováno v: Pediatric blood & cancer [Pediatr Blood Cancer] 2024 Oct; Vol. 71 (10), pp. e31203. Date of Electronic Publication: 2024 Jul 15.

Practice guideline: Preparation for CAR T-cell therapy in children and young adults with B-acute lymphoblastic leukaemia.

Autor: Mishra AK; Great Ormond Street Hospital for Children, London, UK.; University College London, London, UK., Burridge S; Great Ormond Street Hospital for Children, London, UK., Espuelas MO; Great Ormond Street Hospital for Children, London, UK.; University College London, London, UK., O'Reilly M; University College London Hospital, London, UK., Cummins M; University Hospitals Bristol, Bristol, UK., Nicholson E; Royal Marsden Hospital, London, UK., Wheldon S; Leukaemia Care, Worcester, UK., Bonney D; Royal Manchester Children's Hospital, Manchester, UK., Shenton G; Great North Children's Hospital, Newcastle University, Newcastle upon Tyne, UK., Marks DI; University Hospitals Bristol and Weston NHS Trust, Bristol, UK., Amrolia PJ; Great Ormond Street Hospital for Children, London, UK.; University College London, London, UK., Hough R; University College London, London, UK.; University College London Hospital, London, UK., Ghorashian S; Great Ormond Street Hospital for Children, London, UK.; University College London, London, UK.

Publikováno v: British journal of haematology [Br J Haematol] 2024 May; Vol. 204 (5), pp. 1687-1696. Date of Electronic Publication: 2024 Mar 15.

Maintenance therapy for early loss of B-cell aplasia after anti-CD19 CAR T-cell therapy.

Autor: Gabelli M; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom.; Pediatric Onco-hematology and Hematopoietic Stem Cell Transplantation, Woman and Child Health Department, University of Padua, Padua, Italy., Oporto-Espuelas M; Molecular and Cellular Immunology Section, University College London Great Ormond Street Institute of Child Health, London, United Kingdom., Burridge S; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom., Chu J; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom., Farish S; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom., Hedges E; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom., Ware K; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom., Williams L; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom., Young L; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom., Alajangi R; Bristol Haematology and Oncology Centre, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom., Ancliff P; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom., Bartram J; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom., Bonney D; Department of Bone Marrow Transplantation, Royal Manchester Children's Hospital, Manchester, United Kingdom., Chenchara L; Division of Pediatric Hematology Oncology, Sidra Medicine, Doha, Qatar., Chiesa R; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom., Cugno C; Division of Pediatric Hematology Oncology, Sidra Medicine, Doha, Qatar., Hodby K; Bristol Haematology and Oncology Centre, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom., Jalowiec KA; Haematology, University College London Hospital, London, United Kingdom., Lazareva A; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom., Lucchini G; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom., Mirci-Danicar OC; Department of Bone Marrow Transplantation, Royal Hospital for Children, Bristol, United Kingdom., Mullanfiroze K; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom., Pavasovic V; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom., Rao A; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom., Rao K; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom., Riley L; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom., Samarasinghe S; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom., Shenton G; Paediatric Oncology and Haematology, Great North Children's Hospital, Newcastle-upon-Tyne, United Kingdom., Silva J; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom., Vora A; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom., Hough R; Haematology, University College London Hospital, London, United Kingdom., Amrolia PJ; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom.; Molecular and Cellular Immunology Section, University College London Great Ormond Street Institute of Child Health, London, United Kingdom., Ghorashian S; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom.; Developmental Biology and Cancer, University College London Great Ormond Street Institute of Child Health, London, United Kingdom.

Publikováno v: Blood advances [Blood Adv] 2024 Apr 23; Vol. 8 (8), pp. 1959-1963.

Adeno-associated virus 2 infection in children with non-A–E hepatitis

Autor: Ho A, Orton R, Tayler R, Asamaphan P, herder V, Davis C, Tong L, Smollett K, Manali M, Allen J, Rawlik K, McDonald SE, Vink E, Pollock L, Gannon L, Evans C, McMenamin J, Roy K, Marsh K, Divala T, Holden MTG, Lockhart M, Yirrell D, Currie S, O'Leary M, Henderson D, Shepherd SJ, Jackson C, Gunson R, MacLean A, McInnes N, Bradley-Stewart A, Battle R, Hollenbach J, Henderson P, Odam M, Chikowore P, Oosthuyzen W, Chand M, Hamilton MS, Estrada-Rivadeneyra D, Levin M, Avramidis N, Pairo-Castineira E, Vitart V, Wilkie C, Ray S, Emonts,M, Bell,A, Bell,K, Fabian,D, Isaacs,J, Lim,E, Shenton,G, Treloar,O, Van Der Veldon,F, DIAMONDS Consortium, ISARIC4C Investigators

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f84e74fcd275d029a0eae15978132237

Unusual relapse of low hypodiploid acute lymphoblastic leukaemia in a family with Li-Fraumeni syndrome.

Autor: van Delft FW; Department of Paediatric Haematology, Oncology and Bone Marrow Transplantation, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Bailey S; Department of Paediatric Haematology, Oncology and Bone Marrow Transplantation, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Skinner R; Department of Paediatric Haematology, Oncology and Bone Marrow Transplantation, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Shenton G; Department of Paediatric Haematology, Oncology and Bone Marrow Transplantation, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Carey P; Department of Paediatric Haematology, Oncology and Bone Marrow Transplantation, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Campbell-Hewson Q; Department of Paediatric Haematology, Oncology and Bone Marrow Transplantation, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Hale J; Department of Paediatric Haematology, Oncology and Bone Marrow Transplantation, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK., McDonald L; Department of Paediatric Radiology, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Pearce K; Northern Genetics Service, The Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, UK., Martin R; Northern Genetics Service, The Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, UK., Robinson K; Northern Genetics Service, The Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, UK., Cuthbert G; Northern Genetics Service, The Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, UK.

Publikováno v: Pediatric blood & cancer [Pediatr Blood Cancer] 2023 May 28, pp. e30451. Date of Electronic Publication: 2023 May 28.