Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Shenshen Wang"'
Publikováno v:
Physical Review X, Vol 13, Iss 4, p 041004 (2023)
Generative adversarial networks (GANs) are a class of machine-learning models that use adversarial training to generate new samples with the same (potentially very complex) statistics as the training samples. One major form of training failure, known
Externí odkaz:
https://doaj.org/article/e7b014f0ee48490dbc72717d07b041be
Publikováno v:
Materials, Vol 16, Iss 12, p 4442 (2023)
Concrete structures under wind and earthquake loads will experience tensile and compressive stress reversals. It is very important to accurately reproduce the hysteretic behavior and energy dissipation of concrete materials under cyclic tension–com
Externí odkaz:
https://doaj.org/article/52c41f86671d493bbbd2048f75201f63
Autor:
Hongda Jiang, Shenshen Wang
Publikováno v:
Physical Review X, Vol 13, Iss 2, p 021022 (2023)
The adaptive immune system constantly remodels its lymphocyte repertoire for better protection against future pathogens. Its ability to improve antigen recognition on the fly relies on somatic mutation and selective expansion of B lymphocytes express
Externí odkaz:
https://doaj.org/article/d1f92ca787754af59734eeebbe85da16
Autor:
Jiming Sheng, Shenshen Wang
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102861- (2021)
Summary: Highly mutable viruses evolve to evade host immunity that exerts selective pressure and adapts to viral dynamics. Here, we provide a framework for identifying key determinants of the mode and fate of viral-immune coevolution by linking molec
Externí odkaz:
https://doaj.org/article/8c4e38fbede84e8eb0cfcad29851282d
Autor:
Le Yan, Shenshen Wang
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101568- (2020)
Summary: Broadly neutralizing antibodies (bnAbs) recognize conserved features of rapidly mutating pathogens and confer universal protection, but they emerge rarely in natural infection. Increasing evidence indicates that seemingly passive antibodies
Externí odkaz:
https://doaj.org/article/240b7e8543bc419b98da17b75fe9696a
Autor:
Shenshen Wang, Lei Dai
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 10, p e1007320 (2019)
Evolving systems, be it an antibody repertoire in the face of mutating pathogens or a microbial population exposed to varied antibiotics, constantly search for adaptive solutions in time-varying fitness landscapes. Generalists refer to genotypes that
Externí odkaz:
https://doaj.org/article/bdb319c5d05446cdaf66e7f4fdc8523e
Autor:
Hongda Jiang, Shenshen Wang
Publikováno v:
Physical Review Research, Vol 1, Iss 3, p 033164 (2019)
Coevolutionary arms races form between interacting populations that constitute each other's environment and respond to mutual changes. This inherently far-from-equilibrium process finds striking manifestations in the adaptive immune system, where hig
Externí odkaz:
https://doaj.org/article/893795eeb23544aca5b4e37a05e7e8e2
Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction.
Autor:
Shenshen Wang
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 1, p e1005336 (2017)
Affinity maturation is a Darwinian process in which B lymphocytes evolve potent antibodies to encountered antigens and generate immune memory. Highly mutable complex pathogens present an immense antigenic diversity that continues to challenge natural
Externí odkaz:
https://doaj.org/article/fb7b95b1ad5f45e89554d949262de265
Autor:
Devin Sok, Uri Laserson, Jonathan Laserson, Yi Liu, Francois Vigneault, Jean-Philippe Julien, Bryan Briney, Alejandra Ramos, Karen F. Saye, Khoa Le, Alison Mahan, Shenshen Wang, Mehran Kardar, Gur Yaari, Laura M. Walker, Birgitte B. Simen, Elizabeth P. St. John, Po-Ying Chan-Hui, Kristine Swiderek, Stephen H. Kleinstein, Galit Alter, Michael S. Seaman, Arup K. Chakraborty, Daphne Koller, Ian A. Wilson, George M. Church, Dennis R. Burton, Pascal Poignard
Publikováno v:
PLoS Pathogens, Vol 9, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/3d37c901f805490294c80ad1ef2a5381
Autor:
Devin Sok, Uri Laserson, Jonathan Laserson, Yi Liu, Francois Vigneault, Jean-Philippe Julien, Bryan Briney, Alejandra Ramos, Karen F Saye, Khoa Le, Alison Mahan, Shenshen Wang, Mehran Kardar, Gur Yaari, Laura M Walker, Birgitte B Simen, Elizabeth P St John, Po-Ying Chan-Hui, Kristine Swiderek, Steven H Kleinstein, Galit Alter, Michael S Seaman, Arup K Chakraborty, Daphne Koller, Ian A Wilson, George M Church, Dennis R Burton, Pascal Poignard
Publikováno v:
PLoS Pathogens, Vol 9, Iss 11, p e1003754 (2013)
Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination. We used 454 sequencing and designed a novel phylogenetic method to model lineage evolution of the
Externí odkaz:
https://doaj.org/article/2904622cd3c446a68927030a0ec4fe05