Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Shenmeng Gao"'
Autor:
Danyang Li, Yigang Yuan, Chen Meng, Zihan Lin, Min Zhao, Liuzhi Shi, Min Li, Daijiao Ye, Yue Cai, Xiaofei He, Haige Ye, Shujuan Zhou, Haixia Zhou, Shenmeng Gao
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background miR-182 promoter hypermethylation frequently occurs in various tumors, including acute myeloid leukemia, and leads to low expression of miR-182. However, whether adult acute lymphocyte leukemia (ALL) cells have high miR-182 promot
Externí odkaz:
https://doaj.org/article/c44c05750ee741bc967316cdfdac82e9
Autor:
Shuya Feng, Yigang Yuan, Zihan Lin, Min Li, Daijiao Ye, Liuzhi Shi, Danyang Li, Min Zhao, Chen Meng, Xiaofei He, Shanshan Wu, Fang Xiong, Siyu Ye, Junjun Yang, Haifeng Zhuang, Lili Hong, Shenmeng Gao
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract Background Ferroptosis is a new form of nonapoptotic and iron-dependent type of cell death. Glutathione peroxidase-4 (GPX4) plays an essential role in anti-ferroptosis by reducing lipid peroxidation. Although acute myeloid leukemia (AML) cel
Externí odkaz:
https://doaj.org/article/84b5eef75bfa4328af9bf045a1b26690
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
Objectives Constitutive activation of Janus kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway is central to the pathogenesis of myeloproliferative neoplasms (MPNs). Long noncoding RNAs (lncRNAs) regulate divers
Externí odkaz:
https://doaj.org/article/5df421732cf1431bbfc25f2f539c116e
Autor:
Bin Zhou, Xianghong Jin, Weiwei Jin, Xingzhou Huang, Yanfei Wu, Haiying Li, Weijian Zhu, Xiaoyi Qin, Haige Ye, Shenmeng Gao
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-15 (2020)
Abstract Background Overexpression of Wilms’ tumor-1 (WT1) transcription factor facilitates proliferation in acute myeloid leukemia (AML). However, whether WT1 is enriched in the leukemia-initiating cells (LICs) and leukemia stem cells (LSCs) and f
Externí odkaz:
https://doaj.org/article/ff4e25343cd942d58f18a5559e06c132
Autor:
Laixi Bi, Bin Zhou, Haiying Li, Licai He, Chunjing Wang, Zhonggai Wang, Liqing Zhu, Mengqian Chen, Shenmeng Gao
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-17 (2018)
Abstract Background Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies due to sophisticated genetic mutations and epigenetic dysregulation. MicroRNAs (miRNAs), a class of small non-coding RNAs, are important regulator
Externí odkaz:
https://doaj.org/article/1eed7f3b092543e9a31fa1bf3f284b01
Autor:
Junjie Chen, Shenmeng Gao, Chunjing Wang, Zhonggai Wang, Huxiang Zhang, Kate Huang, Bin Zhou, Haiying Li, Zhijie Yu, Jianbo Wu, Chengshui Chen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 35, Iss 1, Pp 1-15 (2016)
Abstract Background The metastatic cascade is a complex and multistep process with many potential barriers. Recently, miR-193a has been reported to be a suppressive miRNA in multiple types of cancers, but its underlying anti-oncogenic activity in non
Externí odkaz:
https://doaj.org/article/1c29705846584c9fa18f5fd0b89e287d
Autor:
FeiYan Xie, Sumayyah Hosany, Shen Zhong, Yang Jiang, Fen Zhang, LiLi Lin, XiaoBo Wang, ShenMeng Gao, XiaoQu Hu
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185565 (2017)
In many cancers, microRNA-193a (miR-193a) is a suppressor miRNA, but its underlying anti-oncogenic activity in breast cancer is not known. In this study, we found decreased miR-193a (specifically, miR-193a-5p) expression not only in breast cancer cel
Externí odkaz:
https://doaj.org/article/3a8d5a47b91f45fcaf1ed8438eaa452e
Autor:
Yixiang Han, Jianbo Wu, Laixi Bi, Shudao Xiong, Shenmeng Gao, Lihui Yin, Lei Jiang, Chiqi Chen, Kang Yu, Shenghui Zhang
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28649 (2011)
Recent evidence has demonstrated that regulatory T cells (Treg) were enriched in the tumor sites of patients with B-cell non-Hodgkin lymphoma (NHL). However, the causes of enrichment and suppressive mechanisms need to be further elucidated. Here we d
Externí odkaz:
https://doaj.org/article/579716a2b8e04f4abecd2be85541e15e
Autor:
Sisi, Ye, Fang, Xiong, Xiaofei, He, Yigang, Yuan, Danyang, Li, Daijiao, Ye, Liuzhi, Shi, Zihan, Lin, Min, Zhao, Shuya, Feng, Bin, Zhou, Huachun, Weng, Lili, Hong, Haige, Ye, Shenmeng, Gao
Publikováno v:
Theranostics. 13:77-94
Autor:
Bin, Liang, Dawei, Jiang, Luqi, Pan, Fang, Xiong, Shuya, Feng, Shenghao, Wu, Haige, Ye, Zhijie, Yu, Changcan, Shi, Shenmeng, Gao
Publikováno v:
Acta Biomaterialia. 145:246-259
Selective BCL2 inhibitor ABT-199 has been approved to treat hematological malignancies including acute myeloid leukemia (AML). However, acquired drug resistance and severe side effects occur after extended treatment limiting the clinical usage of ABT