Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Shengyun Fang"'
Autor:
Yaofu Liu, Yuexi Gu, Ying Chen, Xuan Wang, Guangfeng Zhou, Jing Li, Mu Wang, Shengyun Fang, Yili Yang
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114402- (2024)
Summary: The unfolded protein response (UPR) relieves endoplasmic reticulum (ER) stress through multiple strategies, including reducing protein synthesis, increasing protein folding capabilities, and enhancing misfolded protein degradation. After a m
Externí odkaz:
https://doaj.org/article/754d9c11255b4124949d5c241092395d
Autor:
Wenjing Yan, Yongwang Zhong, Xin Hu, Tuan Xu, Yinghua Zhang, Stephen Kales, Yanyan Qu, Daniel C. Talley, Bolormaa Baljinnyam, Christopher A. LeClair, Anton Simeonov, Brian M. Polster, Ruili Huang, Yihong Ye, Ganesha Rai, Mark J. Henderson, Dingyin Tao, Shengyun Fang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract UBA1 is the primary E1 ubiquitin-activating enzyme responsible for generation of activated ubiquitin required for ubiquitination, a process that regulates stability and function of numerous proteins. Decreased or insufficient ubiquitination
Externí odkaz:
https://doaj.org/article/f3f674c5f7b14cfbb5a8b35c4adc9a3f
Autor:
Xueying Chen, Xiujuan Hu, Jing Jiang, Jie Tao, Lihua Liu, Shengyun Fang, Yuxian Shen, Qingsong Hu, Chao Liu
Publikováno v:
Genes and Diseases, Vol 10, Iss 2, Pp 366-369 (2023)
Externí odkaz:
https://doaj.org/article/f2408eec8567477aafb523620328baec
Autor:
Shengchun Xu, Zemin Di, Yufeng He, Runjie Wang, Yuyang Ma, Rui Sun, Jing Li, Tao Wang, Yujun Shen, Shengyun Fang, Lijie Feng, Yuxian Shen
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Abstract Background Extracellular accumulation of amyloid β-peptide (Aβ) is one of pathological hallmarks of Alzheimer’s disease (AD) and contributes to the neuronal loss. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasm
Externí odkaz:
https://doaj.org/article/866f0c2079444ba7a10c7f5487c79385
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 802 (2022)
The cyclin-dependent kinase inhibitor p27 (Kip1) is an important regulator of the G1/S checkpoint. It is degraded by the SCF-SKP2 complex in late G1 thereby allowing cells to progress to the S phase. Here we investigated the role of the E3 ubiquitin
Externí odkaz:
https://doaj.org/article/0c18529550fd44298ac8b39167c10224
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 599-604 (2015)
DPF2, also named ubi-d4/requiem (REQU), interacts with a protein complex containing OCT4. This paper provides data in support of the research article entitled “DPF2 regulates OCT4 protein level and nuclear distribution”. The highlights include: (
Externí odkaz:
https://doaj.org/article/8e313065ac544f89b7b8fbaa7856fc9f
Publikováno v:
Cells, Vol 9, Iss 5, p 1094 (2020)
Background: Drug resistance is one of the most prevalent causes of death in advanced prostate cancer patients. Combination therapies that target cancer cells via different mechanisms to overcome resistance have gained increased attention in recent ye
Externí odkaz:
https://doaj.org/article/56b86b6421344299ab696d8ca5378c0f
Autor:
Yongwang Zhong, Jiou Wang, Mark J Henderson, Peixin Yang, Brian M Hagen, Teepu Siddique, Bruce E Vogel, Han-Xiang Deng, Shengyun Fang
Publikováno v:
eLife, Vol 6 (2017)
Over 170 different mutations in the gene encoding SOD1 all cause amyotrophic lateral sclerosis (ALS). Available studies have been primarily focused on the mechanisms underlying mutant SOD1 cytotoxicity. How cells defend against the cytotoxicity remai
Externí odkaz:
https://doaj.org/article/7385a4b9f6ca41dc809a49f0ef1d3d6e
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90433 (2014)
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionarily conserved neurotrophic factor which exhibited neuroprotective properties. Recent studies suggested that MANF may play a role in the neural development of Drosophila and z
Externí odkaz:
https://doaj.org/article/c63b69aba4c548a39a2aedb523662246
Autor:
Zhiliang Chen, Yongwang Zhong, Yang Wang, Shan Xu, Zheng Liu, Ilia V Baskakov, Mervyn J Monteiro, Mariusz Karbowski, Yuxian Shen, Shengyun Fang
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73482 (2013)
Proteins can be modified with eight homogenous ubiquitin chains linked by an isopeptide bond between the C-terminus of one ubiquitin and an amine from one of the seven lysines or the N-terminal methionine of the next ubiquitin. These topologically di
Externí odkaz:
https://doaj.org/article/9d501dbbff864b17add11f26eaeccec2