Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Shengnan Xia"'
Autor:
Fahad Paryani, Ji-Sun Kwon, Christopher W. Ng, Kelly Jakubiak, Nacoya Madden, Kenneth Ofori, Alice Tang, Hong Lu, Shengnan Xia, Juncheng Li, Aayushi Mahajan, Shawn M. Davidson, Anna O. Basile, Caitlin McHugh, Jean Paul Vonsattel, Richard Hickman, Michael C. Zody, David E. Housman, James E. Goldman, Andrew S. Yoo, Vilas Menon, Osama Al-Dalahmah
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The mechanisms underlying the selective regional vulnerability to neurodegeneration in Huntington’s disease (HD) have not been fully defined. To explore the role of astrocytes in this phenomenon, we used single-nucleus and bulk RNAseq, lip
Externí odkaz:
https://doaj.org/article/8951e53b83a446a78dbb4875a502960b
Autor:
Yu Bi, Ziyi Xie, Xiang Cao, Huanyu Ni, Shengnan Xia, Xinyu Bao, Qinyue Huang, Yun Xu, Qingxiu Zhang
Publikováno v:
Brain Research Bulletin, Vol 218, Iss , Pp 111102- (2024)
Microglia-associated neuroinflammation plays essential roles in pathology of acute stroke. Cedrol, a natural compound extracted from ginger, has been shown to confer inhibitory effects on inflammation in various diseases. However, whether Cedrol supp
Externí odkaz:
https://doaj.org/article/deac10fc9993461cb888a8c896e58424
Autor:
Chenchen Zhao, Liang Sun, Yuxin Zhang, Xin Shu, Yujie Hu, Duo Chen, Zhi Zhang, Shengnan Xia, Haiyan Yang, Xinyu Bao, Jingwei Li, Yun Xu
Publikováno v:
Brain Research Bulletin, Vol 215, Iss , Pp 111029- (2024)
Background: Microglia-mediated inflammation is a critical factor in the progression of ischemic stroke. Consequently, mitigating excessive microglial activation represents a potential therapeutic strategy for ischemic injury. Thymol, a monophenol der
Externí odkaz:
https://doaj.org/article/a03de46135474d518153236ae62e5828
Autor:
Li-Wen Zhu, Zihao Li, Xiaohong Dong, Huadong Wu, Yifan Cheng, Shengnan Xia, Xinyu Bao, Yun Xu, Runjing Cao
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Macrophages are key inflammatory immune cells that orchestrate the initiation and progression of autoimmune diseases. The characters of macrophage in diseases are determined by its phenotype in response to the local microenvironme
Externí odkaz:
https://doaj.org/article/4e9206efbb914d8fb326943ca790ced7
Autor:
Yi Qian, Lixuan Yang, Jian Chen, Chao Zhou, Ningning Zong, Yang Geng, Shengnan Xia, Haiyan Yang, Xinyu Bao, Yan Chen, Yun Xu
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Background Microglia is the major contributor of post-stroke neuroinflammation cascade and the crucial cellular target for the treatment of ischemic stroke. Currently, the endogenous mechanism underlying microglial activation following ische
Externí odkaz:
https://doaj.org/article/ae377c06ec45437a9738808d0af459e2
Autor:
Huiya Li, Pinyi Liu, Bing Zhang, Zengqiang Yuan, Mengdi Guo, Xinxin Zou, Yi Qian, Shiji Deng, Liwen Zhu, Xiang Cao, Tao Tao, Shengnan Xia, Xinyu Bao, Yun Xu
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-21 (2023)
Abstract Background Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult and initiate immune inflammation, playing an important role in the cellular injury after stroke. How
Externí odkaz:
https://doaj.org/article/1e3c4216c434498db1d0880b75464878
Publikováno v:
Brain Research Bulletin, Vol 207, Iss , Pp 110868- (2024)
Due to various factors, there is still a lack of effective neuroprotective agents for ischemic stroke in clinical practice. Neuroinflammation and neuronal apoptosis mediated by endoplasmic reticulum stress are some of the important pathological mecha
Externí odkaz:
https://doaj.org/article/f66436aff2994588aa70482686ac69e8
Autor:
Qian Cao, Jian Chen, Zhi Zhang, Shu Shu, Yi Qian, Lixuan Yang, Lushan Xu, Yuxin Zhang, Xinyu Bao, Shengnan Xia, Haiyan Yang, Yun Xu, Shuwei Qiu
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Background Chronic cerebral ischemia induces white matter injury (WMI) contributing to cognitive decline. Both astrocytes and microglia play vital roles in the demyelination and remyelination processes, but the underlying mechanism remains u
Externí odkaz:
https://doaj.org/article/ea54554964e245cf92e2966c3ba34edb
Autor:
Junqiu Jia, Lili Zheng, Lei Ye, Jian Chen, Shu Shu, Siyi Xu, Xinyu Bao, Shengnan Xia, Renyuan Liu, Yun Xu, Meijuan Zhang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-13 (2023)
Abstract Ischemic stroke leads to white matter damage and neurological deficits. However, the characteristics of white matter injury and repair after stroke are unclear. Additionally, the precise molecular communications between microglia and white m
Externí odkaz:
https://doaj.org/article/609b0c90972149c4842e4012f1706ab0
Autor:
Xinxin Zou, Shenghan Gao, Jiangnan Li, Chenggang Li, Chuyu Wu, Xiang Cao, Shengnan Xia, Pengfei Shao, Xinyu Bao, Haiyan Yang, Pinyi Liu, Yun Xu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Microglia are the resident macrophages in the brain, which play a critical role in post-stroke neuroinflammation. Accordingly, targeting neuroinflammation could be a promising strategy to improve ischemic stroke outcomes. Ethyl ferulate (EF) has been
Externí odkaz:
https://doaj.org/article/a5d083276ba7486b81760eea4bb50d2b