Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shengkai, Ko"'
Autor:
Chun Hei Antonio Cheung, Wen-Hsing Lin, John Tsu-An Hsu, Tzyh-Chyuan Hour, Teng-Kuang Yeh, Shengkai Ko, Tzu-Wen Lien, Mohane Selvaraj Coumar, Jin-Fen Liu, Wen-Yang Lai, Hui-Yi Shiao, Tian-Ren Lee, Hsing-Pang Hsieh, Jang-Yang Chang
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23485 (2011)
Over-expression of Aurora kinases promotes the tumorigenesis of cells. The aim of this study was to determine the preclinical profile of a novel pan-Aurora kinase inhibitor, BPR1K653, as a candidate for anti-cancer therapy. Since expression of the dr
Externí odkaz:
https://doaj.org/article/2f8104f74c2441ab98528be651d689bf
Autor:
Chie Hong Wang, Shivaji V. More, Ching Fa Yao, Shu-Chuan Jao, Tzu Ting Chang, Shengkai Ko, Ya Ching Jen, Wen-Shan Li
Publikováno v:
Journal of Medicinal Chemistry. 55:1583-1592
Current chemical and biological interest in indole-3-carbinol (I3C) and its metabolites has resulted in the discovery of new biologically active indoles. As part of a program aimed at the development of indole analogues, tetraindoles 1-15 were prepar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4084f2d437ef48c41f58f3bcddea98c
https://doi.org/10.1021/jm2013425
https://doi.org/10.1021/jm2013425
Autor:
Yaochung Jang, Ching Fa Yao, Ju Tsung Liu, Zhijay Tu, Hulin Fang, Yeong Jiunn Jang, Chunchi Lin, Shengkai Ko
Publikováno v:
Tetrahedron Letters. 47:6133-6137
The one-pot synthesis of malononitrile derivatives 4, 6, and 7 in moderate to high yields by the reaction of ylidenemalononitriles 3, prepared in situ from carbonyl compounds 1 and malononitrile 2 in the presence of ammonium acetate in aqueous soluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd120384217889c7490b1d8edfecbf94
https://doi.org/10.1016/j.tetlet.2006.06.061
https://doi.org/10.1016/j.tetlet.2006.06.061
Autor:
Ching Fa Yao, Shengkai Ko
Publikováno v:
Tetrahedron. 62:7293-7299
A facile and efficient one-pot synthesis of high yields of polyhydroquinoline derivatives at ambient temperature using Ceric Ammonium Nitrate (CAN) as catalyst via the Hantzsch reaction was reported. The process is simple and environmentally benign a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1a54898605ddbf1d7a51ef88457cd7
https://doi.org/10.1016/j.tet.2006.05.037
https://doi.org/10.1016/j.tet.2006.05.037
Publikováno v:
Tetrahedron Letters. 46:5771-5774
A simple, inexpensive and efficient one-pot synthesis of 1,4-dihydropyridine derivatives at room temperature using catalytic amount of iodine were reported with excellent product yields. An easy access to various substituted 1,4-dihydropyridine deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6883bbf3ec9dcfd39b68c8a2375b7ca5
https://doi.org/10.1016/j.tetlet.2005.05.148
https://doi.org/10.1016/j.tetlet.2005.05.148
Autor:
Hsing Pang Hsieh, Fu Ming Kuo, Ming Yu Fang, Teng Kuang Yeh, Jim-Tong Horng, Ta Jen Lin, Shengkai Ko, Mohane Selvaraj Coumar, Shin-Ru Shih, Hui Chen Hung, Yu-Sheng Chao, Yen Chun Lee, Yu Lin Huang, Hui Yi Shiao, John T.A. Hsu, Jiann Yih Yeh
Publikováno v:
ChemMedChem. 7(9)
From a high-throughput screening (HTS) hit with inhibitory activity against virus-induced cytophathic in the low micromolar range, we have developed a potent anti-influenza lead through careful optimization without compromising the drug-like properti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acede49520cce70e3e8b876f62807686
https://pubmed.ncbi.nlm.nih.gov/22821876
https://pubmed.ncbi.nlm.nih.gov/22821876
Autor:
Wen-Shan, Li, Chie-Hong, Wang, Shengkai, Ko, Tzu Ting, Chang, Ya Ching, Jen, Ching-Fa, Yao, Shivaji V, More, Shu-Chuan, Jao
Publikováno v:
Journal of medicinal chemistry. 55(4)
Current chemical and biological interest in indole-3-carbinol (I3C) and its metabolites has resulted in the discovery of new biologically active indoles. As part of a program aimed at the development of indole analogues, tetraindoles 1-15 were prepar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6da3f7b71be09b8148bd0afe87e13fb9
https://pubmed.ncbi.nlm.nih.gov/22277074
https://pubmed.ncbi.nlm.nih.gov/22277074
Autor:
Jiann Yih Yeh, Hsing Pang Hsieh, John T.A. Hsu, Shengkai Ko, Kean Seng Lau, Chung-Fan Hsieh, Hui Chen Hung, Yao Chieh Chou, Ta Jen Lin, Jim-Tong Horng, Mei Ling Li, Wen Fang Tang, Ming Sian Wu, Ming Yu Fang
Publikováno v:
Antimicrobial agents and chemotherapy. 56(2)
The aim of this study was to identify the antiviral mechanism of a novel compound, BPR3P0128. From a large-scale screening of a library of small compounds, BPR3P compounds were found to be potent inhibitors of influenza viral replication in Madin–D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c099f4efbb9032e353af029f3ed4d8c
https://pubmed.ncbi.nlm.nih.gov/21930871
https://pubmed.ncbi.nlm.nih.gov/21930871
Autor:
Tzyh-Chyuan Hour, Chun Hei Antonio Cheung, Jin-Fen Liu, Mohane Selvaraj Coumar, Teng-Kuang Yeh, Tian-Ren Lee, Hui Yi Shiao, Tzu-Wen Lien, Shengkai Ko, John T.A. Hsu, Jang Yang Chang, Wen-Hsing Lin, Wen-Yang Lai, Hsing Pang Hsieh
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 8, p e23485 (2011)
PLoS ONE, Vol 6, Iss 8, p e23485 (2011)
Background Over-expression of Aurora kinases promotes the tumorigenesis of cells. The aim of this study was to determine the preclinical profile of a novel pan-Aurora kinase inhibitor, BPR1K653, as a candidate for anti-cancer therapy. Since expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a30fae5d5d10ae37a68757cee467fb
http://europepmc.org/articles/PMC3160846
http://europepmc.org/articles/PMC3160846
Autor:
Yi Ching Wang, Yi Hung Tan, Ching Fa Yao, Shengkai Ko, Sin Ming Huang, Ching Hsiao Lee, Guey Jen Lee-Chen
Publikováno v:
Cancer. 113(4)
BACKGROUND. The clinical responses to chemotherapy in lung cancer patients are unsatisfactory. Thus, the development of more effective anticancer drugs for lung cancer is urgently needed. METHODS. A 2-step novel synthetic compound, referred to as 1,1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702af17b87f2a400d596db749c1922cc
https://pubmed.ncbi.nlm.nih.gov/18618576
https://pubmed.ncbi.nlm.nih.gov/18618576