Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Shenghong, Ma"'
Autor:
Zhengming Wu, Junhui Su, Fu-long Li, Tao Chen, Jaimie Mayner, Adam Engler, Shenghong Ma, Qingquan Li, Kun-Liang Guan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Small cell lung cancer (SCLC) is highly lethal due to its prevalent metastasis. Most SCLCs have inactivating mutations in TP53 and RB1. We find that loss of YAP expression is key for SCLC cells to acquire rapid ameboid migration and high met
Externí odkaz:
https://doaj.org/article/732c3b92988d4b14a5698b812c3e72c0
Autor:
Shenghong Ma, Tracy Tang, Gary Probst, Andrei Konradi, Chunyu Jin, Fulong Li, J. Silvio Gutkind, Xiang-Dong Fu, Kun-Liang Guan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Hippo signalling is reported to be required for proper ESR1 expression. Here the authors reveal that the transcriptional repression of ESR1 is via LATS-YAP-TEAD-VGLL3 axis and the epigenetic regulation of ESR1 super enhancer in ER + breast cancer.
Externí odkaz:
https://doaj.org/article/12adf13f82c94d4989309d2e94fc911d
Autor:
Pu Wang, Jing Wu, Shenghong Ma, Lei Zhang, Jun Yao, Katherine A. Hoadley, Matthew D. Wilkerson, Charles M. Perou, Kun-Liang Guan, Dan Ye, Yue Xiong
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2353-2361 (2015)
Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients. The benefit of this regimen, known as PCV, was recently lin
Externí odkaz:
https://doaj.org/article/ed4bec6145eb44cfa8865cbeb2fca201
Autor:
Mehmet G. Badur, Thangaselvam Muthusamy, Seth J. Parker, Shenghong Ma, Samuel K. McBrayer, Thekla Cordes, Jose H. Magana, Kun-Liang Guan, Christian M. Metallo
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1018-1026.e4 (2018)
Summary: Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research has focused on the hypermethylation phenotypes associated with (D)2-hydroxyglutara
Externí odkaz:
https://doaj.org/article/16efc7f951ff472c8784e31c0e5b4b63
Publikováno v:
Nature Cell Biology. 21:1565-1577
The Hippo pathway plays a critical role in development, tissue homeostasis and organ size; its dysregulation contributes to human diseases. Although MST1/2 and the MAP4Ks are well known as the Hippo kinases, a major open question is how these kinases
Autor:
Shenghong, Ma, Tracy, Tang, Gary, Probst, Andrei, Konradi, Chunyu, Jin, Fulong, Li, J Silvio, Gutkind, Xiang-Dong, Fu, Kun-Liang, Guan
Publikováno v:
Nature communications. 13(1)
Extensive knowledge has been gained on the transcription network controlled by ERα, however, the mechanism underlying ESR1 (encoding ERα) expression is less understood. We recently discovered that the Hippo pathway is required for the proper expres
Publikováno v:
Annual Review of Biochemistry. 88:577-604
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ si
Autor:
Shenghong, Ma, Zhengming, Wu, Feng, Yang, Jianmin, Zhang, Randy L, Johnson, Michael G, Rosenfeld, Kun-Liang, Guan
Publikováno v:
Nature. 591(7848)
Autor:
Shenghong Ma, Kun-Liang Guan, Kimberly C. Lin, Bing Ren, Zhen Ye, Jerrell L. Moore rd, Yunjiang Qiu, Frederick E. Tan, Steven W. Plouffe
Publikováno v:
The Journal of biological chemistry, vol 293, iss 28
The Hippo pathway plays an important role in regulating tissue homeostasis, and its effectors, the transcriptional co-activators Yes-associated protein (YAP) and WW domain-containing transcription regulator 1 (WWTR1 or TAZ), are responsible for media