Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shenghe Tian"'
Autor:
Siqi Xiong, Ajay Kumar, Shenghe Tian, Eman E Taher, Enzhi Yang, Paul R Kinchington, Xiaobo Xia, Yiqin Du
Publikováno v:
eLife, Vol 10 (2021)
Glaucoma is a leading cause of irreversible blindness. In this study, we investigated if transplanted stem cells are able to rescue a glaucoma mouse model with transgenic myocilin Y437H mutation and explored the possible mechanisms. Human trabecular
Externí odkaz:
https://doaj.org/article/f4dede9d3541464b8a84336a192fba28
Autor:
Mara Sullivan, Joseph Weiss, Paul R. Kinchington, Nadezda A. Stepicheva, Peng Shang, Christopher Scott Fitting, José-Alain Sahel, Michael J. Calderon, Shenghe Tian, James T. Handa, Sayan Ghosh, Donald J. Zack, Haitao Liu, Xitiz Chamling, Meysam Yazdankhah, J. Samuel Zigler, Ashwath Jayagopal, Debasish Sinha, Stacey Hose
Publikováno v:
Autophagy
Retinal ganglion cell axons are heavily myelinated (98%) and myelin damage in the optic nerve (ON) severely affects vision. Understanding the molecular mechanism of oligodendrocyte progenitor cell (OPC) differentiation into mature oligodendrocytes wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778ec074da17557e71441b07700e68c0
https://doi.org/10.1080/15548627.2020.1871204
https://doi.org/10.1080/15548627.2020.1871204
Autor:
Paul R. Kinchington, Anil Tiwari, Shenghe Tian, John Gnalian, Sudha Swamynathan, Nicholas Alexander, Shivalingappa K. Swamynathan
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Kruppel-like factor 4 (KLF4) promotes corneal epithelial (CE) cell fate while suppressing mesenchymal properties. TGF-β plays a crucial role in cell differentiation and development, and if dysregulated, it induces epithelial-mesenchymal tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a2bff4d970a10d77dddafbcb4becf8
http://europepmc.org/articles/PMC6383833
http://europepmc.org/articles/PMC6383833
Autor:
Shenghe Tian, Xiaobo Xia, Siqi Xiong, Paul R. Kinchington, Ajay Kumar, Yiqin Du, Eman E. Taher, Enzhi Yang
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Glaucoma is a leading cause of irreversible blindness. In this study, we investigated if exogenous stem cells are able to rescue a glaucoma mouse model with transgenic myocilin Y437H mutation and explored the possible mechanisms. Human trabecular mes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141d27ec8bc6531c4402f2639cae72a2
Autor:
Kimberly M. Brothers, Regis P. Kowalski, Shenghe Tian, Paul R. Kinchington, Robert M.Q. Shanks
Publikováno v:
Experimental Eye Research. 168:12-18
Autophagy protects cells from intracellular pathogens, but can be exploited by some infectious agents to their benefit. Currently it is not known if bacteria induce autohpagy in cells of the cornea. The goal of this study was to develop an ocular sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176650acdd3d5c757c97a8c8bbef8c94
https://doi.org/10.1016/j.exer.2017.12.010
https://doi.org/10.1016/j.exer.2017.12.010
Autor:
Louis D. Falo, Walter J. Storkus, Zuqiang Liu, Jiying Zhang, Guo Chen, Cara Donahue Carey, Zhaoyang You, Shenghe Tian, Kenneth M. Murphy, Yi Zhang
Publikováno v:
The Journal of Immunology. 194:5937-5947
The development of effective cancer vaccines remains an urgent, but as yet unmet, clinical need. This deficiency is in part due to an incomplete understanding of how to best invoke dendritic cells (DC) that are crucial for the induction of tumor-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a06c56089c209d15344fd98f4e2a2927
https://doi.org/10.4049/jimmunol.1500089
https://doi.org/10.4049/jimmunol.1500089
Autor:
Christen Shiber, Shenghe Tian, James L. Funderburgh, Jon W. Johnson, Gregory A. Gibson, Nathan G. Glasgow, Xiaoling Yang, Mengfei Chen, Simon C. Watkins, Joel S. Schuman, Hongjun Liu
Publikováno v:
Aging Cell
Current knowledge indicates that the adult mammalian retina lacks regenerative capacity. Here, we show that the adult stem cell marker, leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), is expressed in the retina of adult mice. Lgr5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a76d14005763638fd84c5fb75163de
http://europepmc.org/articles/PMC4531077
http://europepmc.org/articles/PMC4531077
Publikováno v:
Molecular Therapy. 20(2):432-442
In vivo dendritic cells (DC) targeting is an attractive approach with potential advantages in vaccine efficacy, cost, and availability. Identification of molecular adjuvants to in vivo "modulate " DC to coordinately render improved Th1 and CD8 T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa20a88da35265bdde74c97ee3882b1
Publikováno v:
Gene Therapy. 16:1260-1270
Dendritic cells (DC) engineered in vitro by DNA encoding OVAhsp70 and IL-15 up-regulated their expressions of CD80, CD86, CCR7 and IL-15Ralpha and promoted their productions of IL-6, IL-12 and TNF-alpha. Transcriptional IL-15-directed in vivo DC targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552f4d9076a32f74c47662472dae7460
https://doi.org/10.1038/gt.2009.110
https://doi.org/10.1038/gt.2009.110