Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Shengfang Jin"'
Autor:
Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cancer cells are metabolically adaptable and the identification of specific vulnerabilities is challenging. Here the authors identify a subset of neuroendocrine cell lines exquisitely sensitive to inhibition of SQLE, an enzyme in the cholesterol bios
Externí odkaz:
https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77
Autor:
Eric L. Allen, Danielle B. Ulanet, David Pirman, Christopher E. Mahoney, John Coco, Yaguang Si, Ying Chen, Lingling Huang, Jinmin Ren, Sung Choe, Michelle F. Clasquin, Erin Artin, Zi Peng Fan, Giovanni Cianchetta, Joshua Murtie, Marion Dorsch, Shengfang Jin, Gromoslaw A. Smolen
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 876-890 (2016)
Although aberrant metabolism in tumors has been well described, the identification of cancer subsets with particular metabolic vulnerabilities has remained challenging. Here, we conducted an siRNA screen focusing on enzymes involved in the tricarboxy
Externí odkaz:
https://doaj.org/article/038a8ba083f6473f859242fde11df665
Autor:
Zita Garate, Oscar Quintana-Bustamante, Ana M. Crane, Emmanuel Olivier, Laurent Poirot, Roman Galetto, Penelope Kosinski, Collin Hill, Charles Kung, Xabi Agirre, Israel Orman, Laura Cerrato, Omaira Alberquilla, Fatima Rodriguez-Fornes, Noemi Fusaki, Felix Garcia-Sanchez, Tabita M. Maia, Maria L. Ribeiro, Julian Sevilla, Felipe Prosper, Shengfang Jin, Joanne Mountford, Guillermo Guenechea, Agnes Gouble, Juan A. Bueren, Brian R. Davis, Jose C. Segovia
Publikováno v:
Stem Cell Reports, Vol 5, Iss 6, Pp 1053-1066 (2015)
Pyruvate kinase deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene. Erythrocytes from PKD patients show an energetic imbalance causing chronic non-spherocytic hemolytic anemia, as pyruvate kinase defects impai
Externí odkaz:
https://doaj.org/article/c4e6f66da3a7499d96a1b9ff98b4f2e1
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Figure 1. Synthesis and pharmacokinetic characterization of AG-221. Supplementary Figure 2. Biochemical attributes of AG-221. Supplementary Figure 3. Biochemistry of AG-221 with respect to substrate and cofactor. Supplementary Figure 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d97954935b2f34d5dfe50e66a1f7f5
https://doi.org/10.1158/2159-8290.22531945.v1
https://doi.org/10.1158/2159-8290.22531945.v1
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Table 1. Drug metabolism and pharmacokinetic attributes of AG-221. Supplementary Table 2. Selectivity of AG-221 confirmed by testing against a panel of kinases. Supplementary Table 3. Clinical characteristics of patients with IDH2R140Q-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd472a11c8ff29b3f26438ea494ea5d
https://doi.org/10.1158/2159-8290.22531936
https://doi.org/10.1158/2159-8290.22531936
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf9f6f1fb6d2a1049263137b504fc3a
https://doi.org/10.1158/2159-8290.22531939
https://doi.org/10.1158/2159-8290.22531939
Publikováno v:
2021 IEEE International Conference on Big Data (Big Data).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4177599a269f84c7da85178e85170f6
https://doi.org/10.1109/bigdata52589.2021.9672048
https://doi.org/10.1109/bigdata52589.2021.9672048
Autor:
Shengfang Jin, Stephen P. McCalley, Michelle Clasquin, David Pirman, Kendall Johnson, Jerry Vockley
Publikováno v:
Mol Genet Metab
Branched chain amino acid (BCAA) metabolism occurs within the mitochondrial matrix and is comprised of multiple enzymes, some shared, organized into three pathways for the catabolism of leucine, isoleucine, and valine (LEU, ILE, and VAL respectively)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7dde22b3b4d92329fe7faf85c238a8
https://doi.org/10.1016/j.ymgme.2019.05.008
https://doi.org/10.1016/j.ymgme.2019.05.008
Autor:
Lingling Huang, Kevin Marks, Shengfang Jin, Sung Choe, Scott A. Biller, Joshua Murtie, Gromoslaw A. Smolen, Janeta Popovici-Muller, Eric L. Allen, Rohini Narayanaswamy, Stefan Gross, Yingjia Zhang, Wei Liu, Thomas P. Roddy, Gabrielle McDonald, Nelamangala Nagaraja, Marion Dorsch, Anil K. Padyana, Christopher E. Mahoney, Taryn Sleger, Meina Liu, Yue Chen, Stuart Murray, Victor Chubukov, Sebastian Hayes, Giovanni Cianchetta, Ying Chen, Zi Peng Fan, David Pirman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging. We conducted a chemical biology screen and identified a subset of neuroendocrine tumors dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b9963f98863abf7bfee5a9413bdfc9
https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77
https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77
Autor:
Hua Yang, Muriel D. David, Jeffrey O. Saunders, Lemieux Rene M, Gui Yao, Luke Utley, Véronique Saada, Xiaobing Lv, Yue Chen, Fang Wang, Shengfang Jin, Ping Chen, Erin Artin, Stéphane de Botton, Cheng Fang, Hyeryun Kim, Giovanni Cianchetta, Stefan Gross, Lenny Dang, Zhenwei Cai, Scott A. Biller, Andrew J. Olaharski, Erica Tobin, Cui Dawei, Katharine E. Yen, Virginie Penard-Lacronique, Liping Yan, Ding Zhou, Lee Silverman, Cyril Quivoron, Zhiyong Luo, Jeremy Travins, Janeta Popovici-Muller, Shinsan M. Su, Kimberly Straley, Zhiwei Gu, Francesco G. Salituro
Publikováno v:
ACS Medicinal Chemistry Letters
Somatic point mutations at a key arginine residue (R132) within the active site of the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer a novel gain of function in cancer cells, resulting in the production of d-2-hydroxyglutarate (2-HG), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0eaa35709cac29ca18fde3960dca69
https://doi.org/10.1021/acsmedchemlett.7b00421
https://doi.org/10.1021/acsmedchemlett.7b00421