Zobrazeno 1 - 10
of 310
pro vyhledávání: '"Shengfang Ge"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Uveal melanoma (UM), the most common adult intraocular tumor, is characterized by high malignancy and poor prognosis in advanced stages. Angiogenesis is critical for UM development, however, not only the role of vascular endotheli
Externí odkaz:
https://doaj.org/article/812d671e88f246449f67b327ad7b4c1b
Autor:
Hanhan Shi, Hao Tian, Tianyu Zhu, Qili Liao, Chang Liu, Peng Yuan, Yongyun Li, Jie Yang, Chunyan Zong, Shichong Jia, Jing Ruan, Shengfang Ge, Renbing Jia, Peiwei Chai, Shiqiong Xu, Xianqun Fan
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Conjunctival melanoma (CoM) is a potentially devastating tumor that can lead to distant metastasis. Despite various therapeutic strategies for distant metastatic CoM, the clinical outcomes remain unfavorable. Herein, we performed single-cell
Externí odkaz:
https://doaj.org/article/308ff374b615437b9c05b694d34ef349
Autor:
Liang Ma, Jie Yu, Yidian Fu, Xiaoyu He, Shengfang Ge, Renbing Jia, Ai Zhuang, Zhi Yang, Xianqun Fan
Publikováno v:
MedComm, Vol 5, Iss 9, Pp n/a-n/a (2024)
Abstract Cellular senescence, one of the hallmarks of cancer, is characterized by cell cycle arrest and the loss of most normal cellular functions while acquiring a hypersecretory, proinflammatory phenotype. The function of senescent cells in cancer
Externí odkaz:
https://doaj.org/article/5eee344a33a245aa9270e4d2012a1c15
Autor:
Weihuan Shao, Yiran Yao, Ludi Yang, Xiaoran Li, Tongxin Ge, Yue Zheng, Qiuyi Zhu, Shengfang Ge, Xiang Gu, Renbing Jia, Xin Song, Ai Zhuang
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-34 (2024)
Abstract Adoptive immunotherapy in the T cell landscape exhibits efficacy in cancer treatment. Over the past few decades, genetically modified T cells, particularly chimeric antigen receptor T cells, have enabled remarkable strides in the treatment o
Externí odkaz:
https://doaj.org/article/219d03077d434ae9a374b1e021f3a27c
Autor:
Yongyun Li, Tianyu Zhu, Jie Yang, Qianqian Zhang, Shiqiong Xu, Shengfang Ge, Renbing Jia, Jianming Zhang, Xianqun Fan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1187-1203 (2024)
Constitutive activation of GNAQ/11 is the initiative oncogenic event in uveal melanoma (UM). Direct targeting GNAQ/11 has yet to be proven feasible as they are vital for a plethora of cellular functions. In search of genetic vulnerability for UM, we
Externí odkaz:
https://doaj.org/article/3eb653eb05ac41c1a5eceecc08536f44
Publikováno v:
The Innovation, Vol 5, Iss 2, Pp 100575- (2024)
Externí odkaz:
https://doaj.org/article/07b9f0b404a5476b9c886fffae08a13a
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-23 (2023)
Abstract Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of amino acid metabolic strategies in antitumor therapy. Tremen
Externí odkaz:
https://doaj.org/article/d2a8694cb1604e14bd5840b3560c931c
Autor:
Ai Zhuang, Xiang Gu, Tongxin Ge, Shaoyun Wang, Shengfang Ge, Peiwei Chai, Renbing Jia, Xianqun Fan
Publikováno v:
Cancer Communications, Vol 43, Iss 11, Pp 1185-1206 (2023)
Abstract Background Diversified histone deacetylation inhibitors (HDACis) have demonstrated encouraging outcomes in multiple malignancies. N6‐methyladenine (m6A) is the most prevalent messenger RNA modification that plays an essential role in the r
Externí odkaz:
https://doaj.org/article/4ac9993639d944488fddab79b4e4859c
Autor:
Haoran Ji, Chuang Hu, Xuhui Yang, Yuanhao Liu, Guangyu Ji, Shengfang Ge, Xiansong Wang, Mingsong Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-33 (2023)
Abstract Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune modulation, and secondary dissemination to distant sites through a series of mechanisms, and it has been proved that lymph node metastasis (LNM) is an essenti
Externí odkaz:
https://doaj.org/article/740f39cda8a548ddbcffa60eeb2c865a
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging applications, including as an anti-cancer agent. It boasts the distinct advantages of an excellent safety and tolerability profile and high cost-effec
Externí odkaz:
https://doaj.org/article/2dc34a2e123f4ff5ba7c88e4e4189126