Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Sheng-Quan Hu"'
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 72, Iss 2, Pp 133-135 (2016)
In the title compound, C13H12N2O2 (I), the mean planes of the pyrrole and benzyl rings are approximately perpendicular, forming a dihedral angle of 87.07 (4) °. There is an intramolecular N—H...O hydrogen bond forming an S(7) ring motif. In the cr
Externí odkaz:
https://doaj.org/article/a45afe62f03b4fb1aeb654db44b3b19b
Autor:
Dalinda Isabel Sánchez-Vidaña, Jason Ka Wing Chow, Sheng Quan Hu, Benson Wui Man Lau, Yi-Fan Han
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Background: The exact mechanisms involved in the pathogenesis of neurodegenerative conditions are not fully known. The design of drugs that act on multiple targets represents a promising approach that should be explored for more effective clinical op
Externí odkaz:
https://doaj.org/article/23fdf2970de14e2693d0223279e21c5a
Autor:
Guo-zhen Cui, Jian Chen, Min Ma, Cheng Tao, Sheng-quan Hu, Yuan-ji Chen, Zheng-zhi Wu, Ke-huan Sun
Publikováno v:
Neurochemistry International. 139:104807
The biosynthesis of berberine alkaloids is thought to begin with the demethylation of berberine followed by methylation reactions to generate other type berberine alkaloids. This seemingly expeditious way to access berberine alkaloids has been stagna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4103097d68c09a3e1a01d6bbf6a2ad85
https://doi.org/10.1016/j.neuint.2020.104807
https://doi.org/10.1016/j.neuint.2020.104807
Autor:
Yuan Ping Pang, Yifan Han, Ming Yuen Lee, Wei Cui, Rui Wang, Yuanjia Hu, Shing Hung Mak, Sheng Quan Hu, Gang Li
Publikováno v:
CNS Neuroscience & Therapeutics. 21:953-961
Summary Aims Fibrillar aggregates of β-amyloid protein (Aβ) are the main constituent of senile plaques and considered to be one of the causative events in the pathogenesis of Alzheimer's disease (AD). Compounds that could inhibit Aβ fibrils format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be177746deb397fe869711d605d09a00
https://doi.org/10.1111/cns.12472
https://doi.org/10.1111/cns.12472
Autor:
Xiao-Lei Zhu, Yu Fu, Guang-Fu Yang, Li-Na Jiang, Sheng-Quan Hu, Li Xiong, Wen-Chao Yang, Hua-Wei Gao
Publikováno v:
Journal of agricultural and food chemistry. 64(24)
Succinate-ubiquinone oxidoreductase (SQR) is an attractive target for fungicide discovery. Herein, we report the discovery of novel SQR inhibitors using a pharmacophore-linked fragment virtual screening approach, a new drug design method developed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0f173a60dafafc186e1746754b670b
https://pubmed.ncbi.nlm.nih.gov/27225833
https://pubmed.ncbi.nlm.nih.gov/27225833
Autor:
Rui Wang, Rui San Zhang, Min Chang, Yifan Han, Sheng Quan Hu, Chung Lit Choi, Peng Yali, Pei Wang, Ming Yin, Ren Wen Han
Publikováno v:
Brain Research. 1470:59-68
Our previous reports indicated that bis(propyl)-cognitin (B3C) and bis(heptyl)-cognitin (B7C), as novel dimers derived from tacrine, may be potential multifunctional drugs for treating Alzheimer's disease. There is little knowledge on the cognitive f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b98f810797e3838d08c0ca576de6fd
https://doi.org/10.1016/j.brainres.2012.06.015
https://doi.org/10.1016/j.brainres.2012.06.015
Autor:
Quan Liu, Yu Liang Zhang, Yu Ling Wang, Sheng Quan Hu, Yong Qiang Li, Zhiqiang Feng, Zhu Fang Shen, Lei Lei, Hong Rui Song
Publikováno v:
Chinese Chemical Letters. 22:73-76
A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure–activity relationship (SAR) is di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c35bdd5a1e722d92a16e9e40ecab751
https://doi.org/10.1016/j.cclet.2010.07.023
https://doi.org/10.1016/j.cclet.2010.07.023
Autor:
Karl Wah Keung Tsim, Yuanjia Hu, Wei Cui, Chung Lit Choi, Sheng Quan Hu, Yuan Ping Pang, Yifan Han, Gang Li, Shing Hung Mak
Summary Aims Neurodegenerative disorders are caused by progressive neuronal loss in the brain, and hence, compounds that could promote neuritogenesis may have therapeutic values. In this study, the effects of bis(heptyl)-cognitin (B7C), a multifuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e42e895ccbae96e7fb486a8c7c29cfa
https://europepmc.org/articles/PMC6495446/
https://europepmc.org/articles/PMC6495446/
Autor:
Sheng Quan Hu, Chung Lit Choi, Jing Tang, Da Ping Xu, Yifan Han, Shing Hung Mak, Wei Cui, Yuan Ping Pang
Summary Background Neuronal loss via apoptosis in CNS is the fundamental mechanism underlying various neurodegenerative diseases. Compounds with antiapoptotic property might have therapeutic effects for these diseases. In this study, bis(propyl)-cogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9830154d164f84dbeb0300c8a9ff623d
https://europepmc.org/articles/PMC6493391/
https://europepmc.org/articles/PMC6493391/
Autor:
Yu Qiang Wang, Chung Lit Choi, Sheng Quan Hu, Wei Cui, Zai Jun Zhang, Wah Keung Tsim, Jianhui Rong, Da Ping Xu, Shing Hung Mak, Yifan Han, Ming Yuen Lee
Publikováno v:
CNS neurosciencetherapeutics. 20(3)
Summary Background Sunitinib is an inhibitor of the multiple receptor tyrosine kinases (RTKs) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, the neuroprotective effects of sunitinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c163dac7f55cd5519418aeccfa0c950
https://pubmed.ncbi.nlm.nih.gov/24393200
https://pubmed.ncbi.nlm.nih.gov/24393200