Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Sheng-Ping Wang"'
Autor:
Janos Steffen, Jennifer Ngo, Sheng-Ping Wang, Kevin Williams, Henning F. Kramer, George Ho, Carlos Rodriguez, Krishna Yekkala, Chidozie Amuzie, Russell Bialecki, Lisa Norquay, Andrea R. Nawrocki, Mark Erion, Alessandro Pocai, Orian S. Shirihai, Marc Liesa
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101566- (2022)
Objective: The mitochondrial fission protein Drp1 was proposed to promote NAFLD, as inhibition of hepatocyte Drp1 early in life prevents liver steatosis induced by high-fat diet in mice. However, whether Drp1-knockdown in older mice can reverse estab
Externí odkaz:
https://doaj.org/article/d293ec682a224eca81d3a4cb964a7253
Autor:
Yun-Chen Chang, Wei-Chuan Chiang, Daniel J. Madigan, Fu-Yuan Tsai, Ching-Lung Chiang, Hung-Hung Hsu, Shiow-Mei Lin, Mei-Ying Zhuang, Ching-Ting Sun, Lu-Chi Chen, Sheng-Ping Wang
Publikováno v:
Molecules, Vol 27, Iss 3, p 1073 (2022)
The skipjack tuna (Katsuwonus pelamis) is a mesopredator fish species with seasonal abundance in waters off Taiwan. Regional ecological and life-history information has been historically lacking for this species. In recent years, stable isotope analy
Externí odkaz:
https://doaj.org/article/c3a1a594e9dc4af8bca30d2662043173
Autor:
Douglas G. Johns, Sheng‐Ping Wang, Raymond Rosa, James Hubert, Suoyu Xu, Ying Chen, Thomas Bateman, Robert O. Blaustein
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Anacetrapib is an inhibitor of cholesteryl ester transfer protein (CETP) previously under development as a lipid‐modifying agent that reduces LDL‐cholesterol and increases HDL‐cholesterol in hypercholesterolemic patients. Anacetrapib d
Externí odkaz:
https://doaj.org/article/c8e1dc786577458ead4c45f5d1a68e5f
Autor:
Santhosh Satapati, Ying Qian, Margaret S. Wu, Aleksandr Petrov, Ge Dai, Sheng-ping Wang, Yonghua Zhu, Xiaolan Shen, Eric S. Muise, Ying Chen, Emanuel Zycband, Adam Weinglass, Jerry Di Salvo, John S. Debenham, Jason M. Cox, Ping Lan, Vinit Shah, Stephen F. Previs, Mark Erion, David E. Kelley, Liangsu Wang, Andrew D. Howard, Jin Shang
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 8, Pp 1561-1578 (2017)
GPR40 and GPR120 are fatty acid sensors that play important roles in glucose and energy homeostasis. GPR40 potentiates glucose-dependent insulin secretion and demonstrated in clinical studies robust glucose lowering in type 2 diabetes. GPR120 improve
Externí odkaz:
https://doaj.org/article/1d5d6bb81f4b48f7aa3c095bb5ab4e88
Autor:
Kristian K. Jensen, Marija Tadin-Strapps, Sheng-ping Wang, James Hubert, Yanqing Kan, Yong Ma, David G. McLaren, Stephen F. Previs, Kithsiri B. Herath, Ablatt Mahsut, Andy Liaw, Shubing Wang, Steven J. Stout, CarolAnn Keohan, Gail Forrest, David Coelho, Satya Yendluri, Stephanie Williams, Martin Koser, Steven Bartz, Karen O. Akinsanya, Shirly Pinto
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 12, Pp 2150-2162 (2016)
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2. SREBPs regulate the exp
Externí odkaz:
https://doaj.org/article/bd0a1abbb701431196775362cf9f8457
Autor:
Hong-Ping Guan, Xiaodong Yang, Ku Lu, Sheng-Ping Wang, Jose M. Castro-Perez, Stephen Previs, Michael Wright, Vinit Shah, Kithsiri Herath, Dan Xie, Daphne Szeto, Gail Forrest, Jing Chen Xiao, Oksana Palyha, Li-Ping Sun, Paula J. Andryuk, Samuel S. Engel, Yusheng Xiong, Songnian Lin, David E. Kelley, Mark D. Erion, Harry R. Davis, Liangsu Wang
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2183-2195 (2015)
Glucagon and insulin have opposing action in governing glucose homeostasis. In type 2 diabetes mellitus (T2DM), plasma glucagon is characteristically elevated, contributing to increased gluconeogenesis and hyperglycemia. Therefore, glucagon receptor
Externí odkaz:
https://doaj.org/article/2172e3fff908429b99f72a94d0b8f239
Autor:
Sheng-Ping Wang, Erin Daniels, Ying Chen, Jose Castro-Perez, Haihong Zhou, Karen O. Akinsanya, Stephen F. Previs, Thomas P. Roddy, Douglas G. Johns
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2858-2865 (2013)
Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester and triglyceride between HDL and apoB-containing lipoproteins. Anacetrapib (ANA), a reversible inhibitor of CETP, raises HDL cholesterol and lowers LDL cholesterol in dyslipidemic
Externí odkaz:
https://doaj.org/article/03111596da4743d3967c09a8c2bd6f4b
Autor:
Alison M. Strack, Ester Carballo-Jane, Sheng-ping Wang, Jiyan Xue, Xiaoli Ping, Lesley Ann McNamara, Anil Thankappan, Olga Price, Michael Wolff, T.J. Wu, Douglas Kawka, Michele Mariano, Charlotte Burton, Ching H. Chang, Jing Chen, John Menke, Silvi Luell, Emanuel I. Zycband, Xinchun Tong, Richard Raubertas, Carl P. Sparrow, Brian Hubbard, John Woods, Gary O'Neill, M. Gerard Waters, Ayesha Sitlani
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 177-188 (2013)
The use of nicotinic acid to treat dyslipidemia is limited by induction of a “flushing” response, mediated in part by the interaction of prostaglandin D2 (PGD2) with its G-protein coupled receptor, DP1 (Ptgdr). The impact of DP1 blockade (genetic
Externí odkaz:
https://doaj.org/article/07e92c10466c4bb5bf9831676c97ce7f
Autor:
David G. McLaren, Sheng-Ping Wang, Steven J. Stout, Dan Xie, Paul L. Miller, Vivienne Mendoza, Raymond Rosa, Jose Castro-Perez, Stephen F. Previs, Douglas G. Johns, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 276-281 (2013)
Isotopic tracers have been used to examine lipid trafficking for many years, and data from those studies have typically yielded novel insight regarding the pathophysiology of dyslipidemia. Previous experimental designs were suitable for studies in hu
Externí odkaz:
https://doaj.org/article/0ceebc3cc9db4ae9a404ee79434ed07e
Autor:
Haihong Zhou, Wenyu Li, Sheng-Ping Wang, Vivienne Mendoza, Raymond Rosa, James Hubert, Kithsiri Herath, Theresa McLaughlin, Rory J. Rohm, Michael E. Lassman, Kenny K. Wong, Douglas G. Johns, Stephen F. Previs, Brian K. Hubbard, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1223-1231 (2012)
Stable isotope tracer studies of apoprotein flux in rodent models present difficulties as they require working with small volumes of plasma. We demonstrate the ability to measure apoprotein flux by administering either 2H- or 18O-labeled water to mic
Externí odkaz:
https://doaj.org/article/6c63ed70b4314113b68773d0b93c3352