Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sheng-Nan Xia"'
Autor:
Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu, Xiang Cao
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia. Properdin, which is typically secreted by immune cells suc
Externí odkaz:
https://doaj.org/article/07f1e8682cea45c98c4374537fa7ba75
Autor:
Si-Yi Xu, Jun-Qiu Jia, Min Sun, Xin-Yu Bao, Sheng-Nan Xia, Shu Shu, Pin-yi Liu, Sen-lin Ji, Lei Ye, Xiang Cao, Yun Xu
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107268- (2023)
Summary: Ischemic stroke is the second leading cause of death worldwide, and there are limited effective treatment strategies. QHRD106, a polyethyleneglycol (PEG)-modified long-acting tissue kallikrein preparation, has not been reported previously. I
Externí odkaz:
https://doaj.org/article/f00a754a75e446ddbf39649150c823c3
Autor:
Mei-Ling Yan, Shuai Zhang, Hong-Mei Zhao, Sheng-Nan Xia, Zhuo Jin, Yi Xu, Lin Yang, Yang Qu, Si-Yu Huang, Ming-Jing Duan, Meng Mao, Xiao-Bin An, Chandan Mishra, Xin-Yu Zhang, Li-Hua Sun, Jing Ai
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Chronic brain hypoperfusion (CBH) is closely related to Alzheimer’s disease (AD) and vascular dementia (VaD). Meanwhile, synaptic pathology plays a prominent role in the initial stage of AD and VaD. However, whether and how CBH
Externí odkaz:
https://doaj.org/article/2116e05d016d48288c11b3a9aa001aa2
Autor:
Jian Chen, Pinyi Liu, Jiali Jin, Yue Gu, Hailong Yu, Xiaohong Dong, Xiang Cao, Linjie Yu, Xi Zhang, Xinyu Bao, Yun Xu, Yanting Chen, Xiaolei Zhu, Sheng-Nan Xia
Publikováno v:
Mol Ther
Dysregulated long non-coding RNAs (lncRNAs) have been shown to contribute to the pathogenesis of ischemic stroke. However, the potential role of lncRNAs in post-stroke microglial activation remains largely unknown. Here, we uncovered that lncRNA-U909
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21dbd9561d6c15a1ff40ddfb5829457
https://doi.org/10.1016/j.ymthe.2021.04.025
https://doi.org/10.1016/j.ymthe.2021.04.025
Autor:
Zhen Lan, Jiang-Nan Li, Sheng-Nan Xia, Zhi-Wei Xue, Xinyu Bao, Pinyi Liu, Jian-Wei Ge, Xiaolei Zhu, Yun Xu, Linjie Yu, Yue Gu, Shi-Ji Deng
Publikováno v:
CNS Neuroscience & Therapeutics
Aims Microglia‐mediated neuroinflammation plays an important role in the pathological process of ischemic stroke, and the effect of imperatorin on post‐stroke neuroinflammation is not fully understood. Methods Primary microglia were treated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22143bbf496b45d3c04afc463a12e135
https://pubmed.ncbi.nlm.nih.gov/34674376
https://pubmed.ncbi.nlm.nih.gov/34674376
Autor:
Qiang Li, Xiao-Long Yang, Qin Zhang, Min Zhang, Jian Yang, Yuan Gao, Lan-Ping Guo, Jian Wang, Sheng-Nan Xia, Dong-Mei Lin, Lu-Lin Xu, Lei Zhang, Ya-Hui Liu, Ping Hai, Sheng Wang
Publikováno v:
Fitoterapia. 152
Two novel sulfur-containing dibenzofurans, sorbusins A (1) and B (2), two unprecedented biphenyl glycosides, 2′-hydroxyaucuparin 2′-O-ɑ-L-rhamnoside (3) and noraucuparin 5-O-ɑ-L-rhamnoside (4), and four known analogues (5–8), were isolated fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e6b7534f8535a6d26a8484d1e5ae18
https://pubmed.ncbi.nlm.nih.gov/33940066
https://pubmed.ncbi.nlm.nih.gov/33940066
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Ischemic stroke is a severe and acute neurological disorder with limited therapeutic strategies currently available. Oxidative stress is one of the critical pathological factors in ischemia/reperfusion injury, and high levels of reactive oxygen speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1359a501402c0c830cdf72887f946a09
Autor:
Xiaolei Zhu, Jun-Qiu Jia, Shu Shu, Yue Gu, Yi Liu, Yun Xu, Xinyu Bao, Huijie Bian, Jian Chen, Linjie Yu, Siyi Xu, Xiang Cao, Sheng-Nan Xia, Hui Yang
Publikováno v:
Journal of Alzheimer's disease : JAD. 76(2)
Background Dysfunction of synaptic plasticity leads to memory impairment in Alzheimer's disease (AD). Muscone (Mus) has shown neuroprotective effects in cerebral ischemic models. However, little is known of Mus effects on AD. Objective To investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41de32575526ec02990afd914b753888
https://pubmed.ncbi.nlm.nih.gov/32538849
https://pubmed.ncbi.nlm.nih.gov/32538849
Autor:
Xiao-Bin An, Hong-Mei Zhao, Lin Yang, Sheng-Nan Xia, Si-Yu Huang, Yang Qu, Jing Ai, Shuai Zhang, Mei-Ling Yan, Zhuo Jin
Publikováno v:
Experimental neurology. 332
Chronic cerebral hypoperfusion (CCH) promotes the development of Alzheimer's pathology. However, whether and how CCH impairs the synaptic vesicle trafficking is still unclear. In the present study, we found that the hippocampal glutamatergic vesicle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95dfb8ea4d03355efa295f298516ae2
https://pubmed.ncbi.nlm.nih.gov/32580014
https://pubmed.ncbi.nlm.nih.gov/32580014
Autor:
Siyi Xu, Jun-Qiu Jia, Sheng-Nan Xia, Hui‐jie Bian, Lei Ye, Hui-qin Li, Yue Gu, Xiang Cao, Yun Xu, Xiong Zhu, Shu Shu
Publikováno v:
International Immunopharmacology. 101:108325
Ischemic stroke is a devastating disease with high morbidity and mortality rates, and the proinflammatory microglia-mediated inflammatory response directly affects stroke outcome. Previous studies have reported that JLX001, a novel compound with a st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac2d2cadd594275bc57345ba2c4158d
https://doi.org/10.1016/j.intimp.2021.108325
https://doi.org/10.1016/j.intimp.2021.108325