Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sheng-Na Han"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1353 (2024)
Myocardial fibroblasts play a crucial role in heart structure and function. In recent years, significant progress has been made in understanding the epigenetic regulation of myocardial fibroblasts, which is essential for cardiac development, homeosta
Externí odkaz:
https://doaj.org/article/3a309dc14e1f442796926018db3b57c5
Autor:
Sumra Komal, Atia Gohar, Saad Althobaiti, Ishtiaq Ahmad Khan, Liu-Gen Cui, Li-Rong Zhang, Sheng-Na Han, Muhammad Shakeel
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Heart Failure (HF) is a complex clinical syndrome in which the heart is unable to provide enough blood flow to meet metabolic needs and lacks efficient venous return. HF is a major risk factor for morbidity and mortality with cardiovascular diseases
Externí odkaz:
https://doaj.org/article/239fa0cfad5f4041877079433287c4b0
Autor:
Shu-hui Wang, Meng-jin Sun, Si-yue Ding, Chun-li Liu, Jing-min Wang, Sheng-na Han, Xi Lin, Qian Li
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2023)
Doxorubicin (Dox) is a widely used clinical drug whose cardiotoxicity cannot be ignored. Pyroptosis (inflammatory cell death) has gradually gained attention in the context of Dox-induced cardiotoxicity. In addition to the inhibition of platelet activ
Externí odkaz:
https://doaj.org/article/d82de41f94d64786a8e88ac3af95a1be
Autor:
Sumra Komal, Sheng-Na Han, Liu-Gen Cui, Miao-Miao Zhai, Yue-Jiao Zhou, Pei Wang, Muhammad Shakeel, Li-Rong Zhang
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 141 (2023)
Cardiovascular diseases (CVDs) are the leading cause of hospitalization and death worldwide, especially in developing countries. The increased prevalence rate and mortality due to CVDs, despite the development of several approaches for prevention and
Externí odkaz:
https://doaj.org/article/bdacfa9f620e4a5fa5aa523072e88762
Autor:
Li-Na Xu, Shu-Hui Wang, Xue-Ling Su, Sumra Komal, Hong-Kun Fan, Li Xia, Li-Rong Zhang, Sheng-Na Han
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The aim of this study was to investigate the effects of the GSK-3β/NF-κB pathway on integrin-associated protein (CD47) expression after myocardial infarction (MI) in rats. An MI Sprague Dawley rat model was established by ligating the left anterior
Externí odkaz:
https://doaj.org/article/83403e38367344f3a506ed2a6a4738bb
Publikováno v:
Immunologic Research. 70:607-623
Myocardial infarction (MI) is a life-threatening condition among patients with cardiovascular diseases. MI increases the risk of stroke and heart failure and is a leading cause of morbidity and mortality worldwide. Several genetic and epigenetic fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cceba73b939895fc3386ca9cd267a74
https://doi.org/10.1007/s12026-022-09290-z
https://doi.org/10.1007/s12026-022-09290-z
Autor:
Xue-Ling, Su, Shu-Hui, Wang, Sumra, Komal, Liu-Gen, Cui, Rui-Cong, Ni, Li-Rong, Zhang, Sheng-Na, Han
Publikováno v:
Acta Pharmacologica Sinica. 43:2289-2301
Connexin 43 (Cx43) is the most important protein in the gap junction channel between cardiomyocytes. Abnormalities of Cx43 change the conduction velocity and direction of cardiomyocytes, leading to reentry and conduction block of the myocardium, ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ea0f62617e9bb61171e25318b10a4e
https://doi.org/10.1038/s41401-021-00845-8
https://doi.org/10.1038/s41401-021-00845-8
Autor:
Li-Na Xu, Cheng Chang, Xue-Ling Su, Shu-Hui Wang, Yi-Fan Zeng, Sheng-Na Han, Peng Wang, Lirong Zhang
Publikováno v:
Journal of Interventional Cardiac Electrophysiology. 63:239-248
Abnormal ion channel currents caused by myocardial electrical remodeling is one of the main causes of malignant arrhythmias. Glycogen synthase kinase 3β (GSK-3β) is the main therapeutic target following ischemia as it regulates nerve cell channels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10e2f0e9f66d403ee9c4403d89a97e6
https://doi.org/10.1007/s10840-021-00963-7
https://doi.org/10.1007/s10840-021-00963-7
Autor:
Ming-Xi Zang, Ming-Hui Yang, Sheng-Na Han, Hao Wang, Xin Jia, Meng-Jiao Zhou, Tian-Qi Wang, Si Zhang, Zhongnan Yin, Li-Xiang Xue, Fei-Fei Dai
Publikováno v:
Aging (Albany NY)
Circular RNA (circRNA) is a novel class of noncoding RNAs, and the roles of circRNAs in the development of cardiac hypertrophy remain to be explored. Here, we investigate the potential roles of circRNAs in cardiac hypertrophy. By circRNA sequencing i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd8d44f96fd6317c64954db5a7c952d
https://doi.org/10.18632/aging.102761
https://doi.org/10.18632/aging.102761
Autor:
Shu-Hui Wang, Liu-Gen Cui, Xue-Ling Su, Sumra Komal, Rui-Cong Ni, Ming-Xi Zang, Li-Rong Zhang, Sheng-Na Han
Publikováno v:
European journal of pharmacology. 920
We previously demonstrated that GSK-3β mediates NLRP3 inflammasome activation and IL-1β production in cardiac fibroblasts (CFs) after myocardial infarction (MI). In this study, we show how GSK-3β-mediated activation of the NLRP3 inflammasome/caspa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edc8ff3e459f444d8eb3227eb5b8d00
https://pubmed.ncbi.nlm.nih.gov/35182545
https://pubmed.ncbi.nlm.nih.gov/35182545