Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Sheng-Hao Chao"'
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
The emergence of antibiotic resistant bacteria is one of the biggest threats to human health worldwide. In 2017, World Health Organization listed the world’s most dangerous antibiotic-resistant bacteria or “superbugs,” such as carbapenem-resist
Externí odkaz:
https://doaj.org/article/b9f9ab26a1f446c084c84cf1681f1f1d
Autor:
Vanessa Ding, Qiao Jing Lew, Kai Ling Chu, Subaashini Natarajan, Vikneswari Rajasegaran, Meera Gurumurthy, Andre B H Choo, Sheng-Hao Chao
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72823 (2013)
Hexamethylene bisacetamide inducible protein 1 (HEXIM1) is best known as the inhibitor of positive transcription elongation factor b (P-TEFb), which is composed of cyclin-dependent kinase 9 (CDK9)/cyclin T1. P-TEFb is an essential regulator for the t
Externí odkaz:
https://doaj.org/article/e35298233f04455eb0b3b603e9df2206
Publikováno v:
Bioconjugate Chemistry. 30:920-930
Therapeutic peptides suffer from major drawbacks such as peptide degradation in vivo due to proteolysis. Gold nanoparticles (AuNPs) are an effective carrier for therapeutic peptides that improve their stability in vivo, while also enabling nonspecifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc2e0f2fe225483af481e88d9dfc0f0
https://doi.org/10.1021/acs.bioconjchem.9b00032
https://doi.org/10.1021/acs.bioconjchem.9b00032
Publikováno v:
ACS Biomaterials Science & Engineering. 5:1602-1610
We have previously shown the use of gold nanoparticles (AuNPs) functionalized with DNA (AuNP-DNA) to increase insulin mRNA translation in a cell-free system. In this study, we translate the concept into a whole cell system to demonstrate functionalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f01b5af122ab31255808dc8a454716e
https://doi.org/10.1021/acsbiomaterials.9b00032
https://doi.org/10.1021/acsbiomaterials.9b00032
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 10 (2019)
Frontiers in Microbiology, Vol 10 (2019)
The emergence of antibiotic resistant bacteria is one of the biggest threats to human health worldwide. In 2017, World Health Organization listed the world's most dangerous antibiotic-resistant bacteria or "superbugs," such as carbapenem-resistant Ps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f150c00fd3453ee4f1eb6a2782c9ca
http://europepmc.org/articles/PMC6376162
http://europepmc.org/articles/PMC6376162
Publikováno v:
Amino Acids. 48:1023-1031
Acetylation of histones, the major protein component of eukaryotic chromosomes, contributes to the epigenetic regulation of gene expression and is also involved in cancer development. A recent study revealed the correlation between tumour formation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be12038c4c910745b97eda9b25f6c6f
https://doi.org/10.1007/s00726-015-2148-1
https://doi.org/10.1007/s00726-015-2148-1
Publikováno v:
Oncotarget
// Shu Hui Neo 1 , Qiao Jing Lew 1 , Ser Mei Koh 2 , Lu Zheng 3 , Xuezhi Bi 3 , Sheng-Hao Chao 1, 4 1 Expression Engineering and Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138668 2 Temasek Poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e692a4214ea0868748cde57b36671fe
https://doi.org/10.18632/oncotarget.6794
https://doi.org/10.18632/oncotarget.6794
Tumor Suppressor p14ARF Enhances IFN-γ-Activated Immune Response by Inhibiting PIAS1 via SUMOylation
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(2)
The ability of cells to induce the appropriate transcriptional response to inflammatory stimuli is crucial for the timely induction of host defense mechanisms. Although a role for tumor suppressor p14ARF (ARF) in the innate immune response was previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b0b2ce45a4e8a99489cf0af8854a59
https://pubmed.ncbi.nlm.nih.gov/29848755
https://pubmed.ncbi.nlm.nih.gov/29848755
Publikováno v:
ACS applied materialsinterfaces. 10(6)
DNA-conjugated gold nanoparticles (AuNPs) have been shown to enhance the translation of mRNA. However, the specific sequence on the DNA dictates the specific mRNA to be enhanced. This study describes poly(thymine)-functionalized AuNPs (AuNP-p(T)DNA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a822bb9439e0f7fee90f4434337d652c
https://pubmed.ncbi.nlm.nih.gov/29363938
https://pubmed.ncbi.nlm.nih.gov/29363938
Publikováno v:
Current Protein & Peptide Science. 19
X-box binding protein 1 (XBP-1) is a key regulator of the unfolded protein response (UPR), which is activated in response to endoplasmic reticulum (ER) stress. Cells contain two protein isoforms of XBP-1, the active isoform (XBP-1S) and the inactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1478fc2855052249df49ee94aad3fd83
https://doi.org/10.2174/1389203718666170911144812
https://doi.org/10.2174/1389203718666170911144812