Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sheng Y. Ang"'
Autor:
Martina Kocan, Mohsin Sarwar, Sheng Y. Ang, Jingbo Xiao, Juan J. Marugan, Mohammed A. Hossain, Chao Wang, Dana S. Hutchinson, Chrishan S. Samuel, Alexander I. Agoulnik, Ross A. D. Bathgate, Roger J. Summers
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability. Here we demonstrate that ML290 is a
Externí odkaz:
https://doaj.org/article/dd60bf90c42d4a01bd40b123afd44a23
Autor:
Sarah K, Walsh, Christopher, Lipina, Sheng Y, Ang, Masaaki, Sato, Ling Yeong, Chia, Martina, Kocan, Dana S, Hutchinson, Roger J, Summers, Cherry L, Wainwright
Publikováno v:
Biochemical pharmacology. 188
Emerging evidence suggests that G protein coupled receptor 55 (GPR55) may influence adrenoceptor function/activity in the cardiovascular system. Whether this reflects direct interaction (dimerization) between receptors or signalling crosstalk has not
Autor:
Thomas Egebjerg, Steffen Reedtz-Runge, Christopher J. Langmead, Hari Venugopal, Peishen Zhao, Sheng Y. Ang, Radostin Danev, Patrick M. Sexton, Gregory D. Stewart, David E. Gloriam, Alisa Glukhova, Tin T. Truong, Sebastian G.B. Furness, Christina Rye Underwood, Xin Zhang, Albert J. Kooistra, Laurence J. Miller, Arthur Christopoulos, Petr Šenel, Yi Lynn Liang, Matthew J. Belousoff, Denise Wootten
Publikováno v:
Zhang, X, Belousoff, M J, Zhao, P, Kooistra, A J, Truong, T T, Ang, S Y, Underwood, C R, Egebjerg, T, Šenel, P, Stewart, G D, Liang, Y-L, Glukhova, A, Venugopal, H, Christopoulos, A, Furness, S G B, Miller, L J, Reedtz-Runge, S, Langmead, C J, Gloriam, D E, Danev, R, Sexton, P M & Wootten, D 2020, ' Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists ', Molecular Cell, vol. 80, no. 3, pp. 485-500 . https://doi.org/10.1016/j.molcel.2020.09.020
Peptide drugs targeting class B1 G-protein-coupled receptors (GPCRs) can treat multiple diseases; however, there remains substantial interest in the development of orally delivered non-peptide drugs. Here, we reveal unexpected overlap between signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf3e93793c5fecfb5c14acdfc4376a4
https://curis.ku.dk/portal/da/publications/differential-glp1r-binding-and-activation-by-peptide-and-nonpeptide-agonists(d15f7c32-33ae-43b2-9d9d-b3809a50eb78).html
https://curis.ku.dk/portal/da/publications/differential-glp1r-binding-and-activation-by-peptide-and-nonpeptide-agonists(d15f7c32-33ae-43b2-9d9d-b3809a50eb78).html
Autor:
Bronwyn A Evans, Ross A. D. Bathgate, Martina Kocan, Daniel P. Poole, Romke Bron, Sheng Y. Ang, Roger J. Summers, Jesse J. DiCello, Dana S. Hutchinson
Publikováno v:
Journal of Molecular Endocrinology. 60:213-224
Insulin-like peptide 5 (INSL5) is a newly discovered gut hormone expressed in colonic enteroendocrine L-cells but little is known about its biological function. Here, we show using RT-qPCR and in situ hybridisation that Insl5 mRNA is highly expressed
Autor:
Cherry L. Wainwright, Sarah K. Walsh, Dana S. Hutchinson, Roger J. Summers, Martina Kocan, Masaaki Sato, Sheng Y. Ang, Christopher Lipina, Ling Yeong Chia
Publikováno v:
Biochemical Pharmacology. 188:114560
Emerging evidence suggests that G protein coupled receptor 55 (GPR55) may influence adrenoceptor function/activity in the cardiovascular system. Whether this reflects direct interaction (dimerization) between receptors or signalling crosstalk has not
Autor:
Romke Bron, Bronwyn A Evans, Jesse J. DiCello, Roger J. Summers, Martina Kocan, Ross A. D. Bathgate, Daniel P. Poole, Dana S. Hutchinson, Sheng Y. Ang
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO3-5
Autor:
Roger J. Summers, Sheng Y. Ang
INSL5 is a novel member of the relaxin/insulin superfamily of peptides. It comprises an A-chain with two α helices containing an intrachain disulfide bond covalently bound by two interchain disulfide bonds to a B-chain containing a single α-helix.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::797247ca41dd12a8c3c7469c5625bd01
https://doi.org/10.1016/b978-0-12-801238-3.97214-3
https://doi.org/10.1016/b978-0-12-801238-3.97214-3
Publikováno v:
Obesity Research & Clinical Practice. 13:41-42
Autor:
Mark A. Schembri, Roger J. Summers, Jamie Rossjohn, Martina Kocan, Oded Kleifeld, James C. Paton, Adrienne W. Paton, Sheng Y. Ang, Travis Clarke Beddoe, Dene R. Littler, Mai T. Tran, Danilo Gomes Moriel, Matthew D. Johnson
Pertussis-like toxins are secreted by several bacterial pathogens during infection. They belong to the AB5 virulence factors, which bind to glycans on host cell membranes for internalization. Host cell recognition and internalization are mediated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf5497950b2a10deb3fdba8cd2dce77
Autor:
Ross A. D. Bathgate, Juan J. Marugan, Jingbo Xiao, Mohammed Akhter Hossain, Dana S. Hutchinson, Chao Wang, Martina Kocan, Sheng Y. Ang, Mohsin Sarwar, Alexander I. Agoulnik, Chrishan S. Samuel, Roger J. Summers
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability. Here we demonstrate that ML290 is a biased a