Výsledky vyhledávání

Akademický článek

Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia

Autor: Lokensgard James R, Schachtele Scott J, Sheng Wen S, Hu Shuxian

Publikováno v: Journal of Neuroinflammation, Vol 8, Iss 1, p 123 (2011)

Abstract Background Production of reactive oxygen species (ROS) and proinflammatory cytokines by microglial cells in response to viral brain infection contributes to both pathogen clearance and neuronal damage. In the present study, we examined the e

Externí odkaz: https://doaj.org/article/78f5a35090744402a0a467076ff6ca13

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Akademický článek

Hemin inhibits NO production by IL-1β-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation

Autor: Sheng Wen S, Hu Shuxian, Nettles Adam R, Lokensgard James R, Vercellotti Gregory M, Rock R Bryan

Publikováno v: Journal of Neuroinflammation, Vol 7, Iss 1, p 51 (2010)

Abstract Background Heme oxygenase (HO)-1 has been shown to attenuate oxidative injury and reduce apoptosis. HO-1 can be induced by various stimuli released during cellular injury, such as heme. Deleterious free heme is degraded by HO-1 to carbon mon

Externí odkaz: https://doaj.org/article/de6e435d2c5745cf86ebfc4a4f318092

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Akademický článek

Morphine stimulates CCL2 production by human neurons

Autor: Sheng Wen S, Hu Shuxian, Rock R Bryan, Peterson Phillip K

Publikováno v: Journal of Neuroinflammation, Vol 3, Iss 1, p 32 (2006)

Abstract Background Substances of abuse, such as opiates, have a variety of immunomodulatory properties that may influence both neuroinflammatory and neurodegenerative disease processes. The chemokine CCL2, which plays a pivotal role in the recruitme

Externí odkaz: https://doaj.org/article/bcfe9d915c594c97a0f2e3d1bd5b5c73

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