Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Sheng T Hou"'
Autor:
Sandhya Gangaraju, Khadeejah Sultan, Shawn N. Whitehead, Ladan Nilchi, Jacqueline Slinn, Xuesheng Li, Sheng T. Hou
Publikováno v:
Neurobiology of Disease, Vol 54, Iss , Pp 24-31 (2013)
Increased brain infiltration of polymorphonuclear neutrophils (PMNs) occurs early after stroke and is important in eliciting brain inflammatory response during stroke recovery. In order to understand the molecular mechanism of PMN entry, we investiga
Externí odkaz:
https://doaj.org/article/fe848386d0b94df591b1e2456b4178ab
Autor:
Shawn N Whitehead, Kenneth H N Chan, Sandhya Gangaraju, Jacqueline Slinn, Jianjun Li, Sheng T Hou
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20808 (2011)
Gangliosides, a member of the glycosphingolipid family, are heterogeneously expressed in biological membranes and are particularly enriched within the central nervous system. Gangliosides consist of mono- or poly-sialylated oligosaccharide chains of
Externí odkaz:
https://doaj.org/article/21bfdb89dca94603802ab32e69759713
Autor:
Chantel L. Benson, Xiumei Han, Suzanne R. Abrams, L. Irina Zaharia, Sheng T. Hou, Susan X. Jiang, Jacqueline Slinn
Publikováno v:
Journal of Biological Chemistry. 291:27007-27022
Phaseic acid (PA) is a phytohormone regulating important physiological functions in higher plants. Here, we show the presence of naturally occurring (−)-PA in mouse and rat brains. (−)-PA is exclusively present in the choroid plexus and the cereb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab5b7622246f6997adbe91c9e3d31b8
https://doi.org/10.1074/jbc.m116.756429
https://doi.org/10.1074/jbc.m116.756429
Autor:
Sheng T. Hou, Meijuan Xiao, Zusen Ye, Man Qu, Liang Feng, Zhao Han, Rong-Yuan Zheng, Yungang Cao, Zheng Zhang, Shuang Liu
Publikováno v:
Neurological research. 38(6)
To investigate whether curcumin regulates Notch signaling to cause neuroprotection and neurogenesis after focal ischemia reperfusion injury.Focal ischemia reperfusion injury was modeled in rats by occluding the middle cerebral artery. These animals w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e64ad9e1bba648a0e2e406315dc533
https://pubmed.ncbi.nlm.nih.gov/27320251
https://pubmed.ncbi.nlm.nih.gov/27320251
Publikováno v:
Journal of Neurochemistry. 122:764-774
Microglia are the 'immune cells' of the brain and their activation plays a vital role in the pathogenesis of many neurodegenerative diseases. Activated microglia produce high levels of pro-inflammatory factors, such as TNFα, causing neurotoxicity. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f6c75dc63eace0f5eb928e309da7b0a
https://doi.org/10.1111/j.1471-4159.2012.07823.x
https://doi.org/10.1111/j.1471-4159.2012.07823.x
Publikováno v:
European Journal of Pharmacology. 629:12-19
Intracellular calcium ([Ca(2+)]i) influx through N-methyl-d-aspartic acid (NMDA) receptors in cortical neurons is central to NMDA receptor-mediated excitotoxicity. Drugs that uncompetitively modulate NMDA receptor-mediated [Ca(2+)]i influx are potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47c17efbb50f13b5ab719221caa318f
https://doi.org/10.1016/j.ejphar.2009.11.063
https://doi.org/10.1016/j.ejphar.2009.11.063
Autor:
Sheng T. Hou, Susan X. Jiang, Thomas Leung, Amy Aylsworth, Jacqueline Slinn, Graeme Ferguson, Kozo Kaibuchi, Joachim Kappler, Houwen Hu
Publikováno v:
Journal of Neurochemistry. 111:870-881
Intracellular calcium influx through NMDA receptors triggers a cascade of deleterious signaling events which lead to neuronal death in neurological conditions such as stroke. However, it is not clear as to the molecular mechanism underlying early dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59db80f17b22e43c59d2a06613b1cfdb
https://doi.org/10.1111/j.1471-4159.2009.06375.x
https://doi.org/10.1111/j.1471-4159.2009.06375.x
Autor:
Susan X. Jiang, Amy Aylsworth, Bogdan Zurakowski, Angele Desbois, Joachim Kappler, Sheng T. Hou
Publikováno v:
European Journal of Neuroscience. 26:801-809
Collapsin response mediator proteins (CRMPs) are important brain-specific proteins with distinct functions in modulating growth cone collapse and axonal guidance during brain development. Our previous studies have shown that calpain cleaves CRMP3 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::223f8a002401f610b149cc146764468f
https://doi.org/10.1111/j.1460-9568.2007.05715.x
https://doi.org/10.1111/j.1460-9568.2007.05715.x
Autor:
Kristen M. Leenhouts, Lisa R. Warner, Eliezer Masliah, Mel B. Feany, Susan X. Jiang, Julia Thom Oxford, Teresa Gomez-Isla, Sheng T. Hou, Troy T. Rohn, Brian M. Dufty
Publikováno v:
The American Journal of Pathology. 170:1725-1738
Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are both characterized pathologically by the presence of neuronal inclusions termed Lewy bodies (LBs). A common feature found in LBs are aggregates of alpha-synuclein (alpha-Syn), and altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa4bb23309c383c1dccd610f473e5289
https://doi.org/10.2353/ajpath.2007.061232
https://doi.org/10.2353/ajpath.2007.061232
Publikováno v:
Molecular and Cellular Biology. 27:1696-1705
The nuclear transcription factor E2F1 plays an important role in modulating neuronal death in response to excitotoxicity and cerebral ischemia. Here, by comparing gene expression in brain cortices from E2F1(+/+) and E2F1(-/-) mice using a custom high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f57c3a2e7b2cbe01efd692e9263bc59
https://doi.org/10.1128/mcb.01760-06
https://doi.org/10.1128/mcb.01760-06