Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Sheng Jiun Wu"'
Autor:
Lauren E. Boucher, Elisabeth Geyer Prinslow, Michael Feldkamp, Fang Yi, Rupesh Nanjunda, Sheng-Jiun Wu, Tun Liu, Eilyn R. Lacy, Steven Jacobs, Natalia Kozlyuk, Brian Del Rosario, Bingyuan Wu, Patricia Aquino, Robert C. Davidson, Samantha Heyne, Nicholas Mazzanti, James Testa, Michael D. Diem, Elsa Gorre, Andrew Mahan, Hirsh Nanda, Harsha P. Gunawardena, Alexis Gervais, Anthony A. Armstrong, Alexey Teplyakov, Chichi Huang, Adam Zwolak, Partha Chowdhury, Wan Cheung Cheung, Jinquan Luo
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTSingle-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric antigen receptor T cells or natural killer cells. However, scFv domains exhibit lo
Externí odkaz:
https://doaj.org/article/07a49e5767d741f0bc24b50e3af689e1
Autor:
G. Mark Anderson, Matthew V. Lorenzi, Sylvie Laquerre, Ricardo M. Attar, Janine Schuurman, Paul W.H.I. Parren, Joost Neijssen, Pauline L. Martin, Sheng-Jiun Wu, Thomas Kelly, Peter Haytko, Randall J. Brezski, Keri Dorn, Leopoldo Luistro, Kristen Chevalier, Barbara S. Bushey, Mark L. Chiu, Sheri L. Moores
Origins and Genotypes of Lung Cancer Tumor Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12db4f9e5f35d769dd8b8db321a69047
https://doi.org/10.1158/0008-5472.22406622.v1
https://doi.org/10.1158/0008-5472.22406622.v1
Autor:
G. Mark Anderson, Matthew V. Lorenzi, Sylvie Laquerre, Ricardo M. Attar, Janine Schuurman, Paul W.H.I. Parren, Joost Neijssen, Pauline L. Martin, Sheng-Jiun Wu, Thomas Kelly, Peter Haytko, Randall J. Brezski, Keri Dorn, Leopoldo Luistro, Kristen Chevalier, Barbara S. Bushey, Mark L. Chiu, Sheri L. Moores
Non–small cell lung cancers (NSCLC) with activating EGFR mutations become resistant to tyrosine kinase inhibitors (TKI), often through second-site mutations in EGFR (T790M) and/or activation of the cMet pathway. We engineered a bispecific EGFR-cMet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08558d1a5bde3c55c0598591e7cde318
https://doi.org/10.1158/0008-5472.c.6507129
https://doi.org/10.1158/0008-5472.c.6507129
Autor:
G. Mark Anderson, Matthew V. Lorenzi, Sylvie Laquerre, Ricardo M. Attar, Janine Schuurman, Paul W.H.I. Parren, Joost Neijssen, Pauline L. Martin, Sheng-Jiun Wu, Thomas Kelly, Peter Haytko, Randall J. Brezski, Keri Dorn, Leopoldo Luistro, Kristen Chevalier, Barbara S. Bushey, Mark L. Chiu, Sheri L. Moores
Efficacy of JNJ-61186372 in H292-HGF Xenograft Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f90aafe25224f65576a2b1dcee502b4
https://doi.org/10.1158/0008-5472.22406625
https://doi.org/10.1158/0008-5472.22406625
Autor:
Anna Kuchnio, Danlin Yang, Nele Vloemans, Cassandra Lowenstein, Ivo Cornelissen, Ricardo Amorim, Chao Han, Siddharth Sukumaran, Lut Janssen, Toon Suls, Mariette Bekkers, Elena Lasorsa, Lorena Fontana, Nicole Medeiros, Bingyuan Wu, Jun Chen, Michael Feldkamp, Sheng-Jiun Wu, Habtom Habte, John Krayer, Cam Holland, M. Phillip Deyoung, Yusri A Elsayed, Ulrike Philippar
Publikováno v:
Blood. 140:3105-3106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1400068381b3f118949b0557ac22f5fa
https://doi.org/10.1182/blood-2022-168739
https://doi.org/10.1182/blood-2022-168739
Autor:
Thomas J. Malia, Marc Vandermeeren, Hong Sun, Kristof Van Kolen, Marc Mercken, Rupesh Nanjunda, Gallen Triana-Baltzer, M. Borgers, Astrid Bottelbergs, Eilyn R. Lacy, Alexey Teplyakov, Tom Van De Casteele, John Q. Trojanowski, Clara Theunis, Hervé Maurin, Peter Larsen, Robin Ernst, Sheng-Jiun Wu, Cindy Wintmolders, Roland Willems, Randy Slemmon, Wendy Galpern, Jinquan Luo
Publikováno v:
Journal of Alzheimer's Disease. 77:1397-1416
Background: As a consequence of the discovery of an extracellular component responsible for the progression of tau pathology, tau immunotherapy is being extensively explored in both preclinical and clinical studies as a disease modifying strategy for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6c6c8a8bbb34392a44d1677aa443be
https://doi.org/10.3233/jad-200544
https://doi.org/10.3233/jad-200544
Autor:
Nikki DeAngelis, Catherine Ferrante, Gordon Powers, Jocelyn Sendecki, Bethany Mattson, Darlene Pizutti, Kathryn Packman, Weirong Wang, Kevin Trouba, Rupesh Nanjunda, John Wheeler, Ray Brittingham, Sheng-Jiun Wu, Jinquan Luo, Matthew V. Lorenzi, Raluca I. Verona
Publikováno v:
Cancer chemotherapy and pharmacology. 89(4)
Purpose Preclinical characterization of cetrelimab (JNJ-63723283), a fully humanized immunoglobulin G4 kappa monoclonal antibody targeting programmed cell death protein-1 (PD-1), in human cancer models. Methods Cetrelimab was generated by phage panni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65f7a79203f381f3e394d4cf7ab1740
https://pubmed.ncbi.nlm.nih.gov/35298699
https://pubmed.ncbi.nlm.nih.gov/35298699
Autor:
Susan H. Tam, Stephen G. McCarthy, Anthony A. Armstrong, Sandeep Somani, Sheng-Jiun Wu, Xuesong Liu, Alexis Gervais, Robin Ernst, Dorina Saro, Rose Decker, Jinquan Luo, Gary L. Gilliland, Mark L. Chiu, Bernard J. Scallon
Publikováno v:
Antibodies, Vol 6, Iss 3, p 12 (2017)
Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc gamm
Externí odkaz:
https://doaj.org/article/e4effcd57176409f88ce8c9b266a42aa
Autor:
Sandra Santulli-Marotto, Ken Boakye, Eilyn Lacy, Sheng-Jiun Wu, Jennifer Luongo, Karl Kavalkovich, Ana Coelho, Cory M Hogaboam, Mary Ryan
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81465 (2013)
CCL17 (TARC) function can be completely abolished by mAbs that block either one of two distinct sites required for CCR4 signaling. This chemokine is elevated in sera of asthma patients and is responsible for establishing inflammatory sites through CC
Externí odkaz:
https://doaj.org/article/5113c4a64a82451fa5aa82a94e39f868
Autor:
Damien Fink, Kathryn Packman, Yusri Elsayed, Mattson Bethany Kay, Brad Foulk, Qun Jiao, Priyanka Nair-Gupta, Dara Reeves, Bradley Heidrich, Jocelyn Sendecki, Mark Mendonca, Robert Schulingkamp, Gerald Chu, Katrin Sproesser, Sheng-Jiun Wu, Francois Gaudet, Jocelin Joseph, Ricardo Attar, Weirong Wang, Michael Diem
CD33 is expressed in 90% of patients with acute myeloid leukemia (AML), and its extracellular portion consists of a V domain and a C2 domain. A recent study showed that a single nucleotide polymorphism (SNP), rs12459419 (C > T), results in the reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba88eb51322ab5e28745ce9713e19c8
https://europepmc.org/articles/PMC7065489/
https://europepmc.org/articles/PMC7065489/