Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Sheng Biao Wan"'
Publikováno v:
Marine Drugs, Vol 12, Iss 10, Pp 5209-5221 (2014)
In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relat
Externí odkaz:
https://doaj.org/article/6a8ebc29db2b475295478b6bbec1e5e2
Autor:
Sopana Jamornwan, Sheng-Biao Wan, Chotchanit Sunrat, Kai-Rui Yue, Erik W. Dent, Kwanchanok Uppakara, Liang-Xing Duan, Witchuda Saengsawang
Publikováno v:
ACS Chemical Neuroscience. 11:1634-1642
Neurodegenerative diseases are irreversible conditions that result in progressive degeneration and death of nerve cells. Although the underlying mechanisms may vary, oxidative stress is considered to be one of the major causes of neuronal loss. Impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::194e47bc2d7231df9f64c110611b3233
https://doi.org/10.1021/acschemneuro.0c00105
https://doi.org/10.1021/acschemneuro.0c00105
Autor:
Zhi-Kun Guo, Ying-Zhi Zhang, Yu-Hang Zhang, Dong-Dong Luo, Sheng-Biao Wan, Xianjun Qu, shuxiang cui
Background and Purpose: Dihydropyrimidine dehydrogenase (DPD) is a major determinant of 5-FU resistance in cancers. DPD catalyzes 5-FU into FBAL (α-fluoro-β-alanine) to lower intracellular 5-FU level. We aimed to investigate mechanism and clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1e59028a180bc657a60957aff5667db
https://doi.org/10.22541/au.164375702.24504582/v1
https://doi.org/10.22541/au.164375702.24504582/v1
Publikováno v:
Organic Chemistry Frontiers. 6:1972-1976
The [3 + 3]-cycloaddition reaction of chroman-2-ols with β,γ-unsaturated α-ketoesters via an enamine-catalyzed sequential process is reported. The protocol provides efficient access to polycyclic hemiketal-containing compounds, which could be conv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb9df398fc847a9086d77e386d01e0e6
https://doi.org/10.1039/c9qo00366e
https://doi.org/10.1039/c9qo00366e
Autor:
Kwanchanok, Uppakara, Sopana, Jamornwan, Liang-Xing, Duan, Kai-Rui, Yue, Chotchanit, Sunrat, Erik W, Dent, Sheng-Biao, Wan, Witchuda, Saengsawang
Publikováno v:
ACS chemical neuroscience. 11(11)
Neurodegenerative diseases are irreversible conditions that result in progressive degeneration and death of nerve cells. Although the underlying mechanisms may vary, oxidative stress is considered to be one of the major causes of neuronal loss. Impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f413b83d0f6da87eb9c4f3602d34b6a9
https://pubmed.ncbi.nlm.nih.gov/32374999
https://pubmed.ncbi.nlm.nih.gov/32374999
Autor:
Yu-Hang, Zhang, Wen-Na, Shi, Shu-Hua, Wu, Rong-Rong, Miao, Shi-Yue, Sun, Dong-Dong, Luo, Sheng-Biao, Wan, Zhi-Kun, Guo, Wen-Yu, Wang, Xin-Feng, Yu, Shu-Xiang, Cui, Xian-Jun, Qu
Publikováno v:
Oncogene. 39(29)
Aberrant sphingolipid metabolism has been implicated in chemoresistance, but the underlying mechanisms are still poorly understood. Herein we revealed a previously unrecognized mechanism of 5-fluorouracil (5-FU) resistance contributed by high SphK2-u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a30d0ab64b0d0716e6324fd9794ec8ef
https://pubmed.ncbi.nlm.nih.gov/32546724
https://pubmed.ncbi.nlm.nih.gov/32546724
Autor:
Dong-Dong, Luo, Kai, Peng, Jia-Yu, Yang, Pawinee, Piyachaturawat, Witchuda, Saengsawang, Lei, Ao, Wan-Zhou, Zhao, Yu, Tang, Sheng-Biao, Wan
Publikováno v:
RSC advances. 8(52)
A simple and efficient protocol was developed for the syntheses of oridonin analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8615fdc764ebd4aee307d390cb51cbe7
https://pubmed.ncbi.nlm.nih.gov/35547324
https://pubmed.ncbi.nlm.nih.gov/35547324
Autor:
Iris L. K. Wong, Fu Xing Li, Zhen Wang, Tao Jiang, Chao Yang, Ting Fu Jiang, Zhen Liu, Larry M.C. Chow, Sheng Biao Wan
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5566-5573
In the present study, a total of 9 novel permethyl ningalin B analogs have been synthesized and evaluated for their P-gp modulating activity in a P-gp overexpressed breast cancer cell line LCC6MDR. Among these derivatives, compound 12 with dimethoxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0bba5d2029a155de3b8567aaa2dcfb
https://doi.org/10.1016/j.bmc.2015.07.027
https://doi.org/10.1016/j.bmc.2015.07.027
Autor:
Tao Jiang, Tingfu Jiang, Peng Wang, Iris L. K. Wong, Larry M.C. Chow, Sheng Biao Wan, Kai Peng, Zhen Liu, Chao Yang
Publikováno v:
European journal of medicinal chemistry. 125
In the present study, a total of 25 novel ningalin B analogues were synthesized and evaluated for their P-gp modulating activity in a P-gp overexpressed breast cancer cell line LCC6MDR. Preliminary structure-activity study shows that A ring and its t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243e02ecdd51c7265d8e8c270db0d9ab
https://pubmed.ncbi.nlm.nih.gov/27750197
https://pubmed.ncbi.nlm.nih.gov/27750197
Autor:
Tao Jiang, Xue Min Li, Di Chen, Sheng Biao Wan, Xu Long Qin, Jian Yuan, Q. Ping Dou, Tak Hang Chan
Publikováno v:
Synthetic Communications. 42:3524-3531
In the present study, four fluoro-substituted benzoates of epi-gallocatechin (EGC) were prepared through a semisynthetic strategy, and the yield of benzylation of epi-gallocatechin gallate (−)-EGCG was improved by using freshly purified (−)-EGCG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83263bad22aaadf669ce870c0edc6c77
https://doi.org/10.1080/00397911.2011.585269
https://doi.org/10.1080/00397911.2011.585269