Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Shenaz Khan"'
Autor:
Kenneth R. Laurita, Shenaz Khan, Tracy McMahon, Adrienne T. Dennis, Vincent Li, Robert Gaivin, Hima Sapa, Ji-dong Fu, Jeffrey R. Schelling
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Chronic kidney disease (CKD) affects more than 20 million people in the US, and it is associated with a significantly increased risk of sudden cardiac death (SCD). Despite the significance, the mechanistic relationship between SCD and CKD is
Externí odkaz:
https://doaj.org/article/928179ec18204ab3a05319cdaade74b5
Autor:
Ji-Dong Fu, Hima Sapa, Kenneth R. Laurita, Tracy McMahon, Adrienne T. Dennis, Robert Gaivin, Jeffrey R. Schelling, Shenaz Khan, Vincent Li
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Chronic kidney disease (CKD) affects more than 20 million people in the US, and it is associated with a significantly increased risk of sudden cardiac death (SCD). Despite the significance, the mechanistic relationship between SCD and CKD is not clea
Autor:
Jeffrey R. Schelling, Michael Boylan, Shenaz Khan, Jorge Calles, Robert Gaivin, Caroline Abramovich
Publikováno v:
JCI Insight
Kidney disease is one of the most devastating complications of diabetes, and tubular atrophy predicts diabetic kidney disease (DKD) progression to end-stage renal disease. We have proposed that fatty acids bound to albumin contribute to tubular atrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd077932c723c1bc92a83b1c509a46e6
https://europepmc.org/articles/PMC7455077/
https://europepmc.org/articles/PMC7455077/
Autor:
Zachary W. Schmidt, William P. Schilling, Pablo D. Cabral, Amelia Gingras, Jeffrey R. Schelling, Sethu M. Madhavan, Shenaz Khan, Jeffrey L. Garvin, Asif N. Uddin
Publikováno v:
Journal of the American Society of Nephrology. 29:81-91
Albuminuria and tubular atrophy are among the highest risks for CKD progression to ESRD. A parsimonious mechanism involves leakage of albumin-bound nonesterified fatty acids (NEFAs) across the damaged glomerular filtration barrier and subsequent reab
Publikováno v:
American Journal of Physiology-Renal Physiology. 306:F1400-F1409
αvβ8-Integrin is most abundantly expressed in the kidney, brain, and female reproductive organs, and its cognate ligand is latent transforming growth factor (LTGF)-β. Kidney αvβ8-integrin localizes to mesangial cells, and global β8-integrin gen
Autor:
Jeffrey R. Schelling, Shenaz Khan, Louis F. Reichardt, John R. Sedor, Nader Sheibani, Joseph H. McCarty, Christine M. Sorenson, Bingcheng Wang, Jane H. Kim, Sujata Lakhe-Reddy
Publikováno v:
The American Journal of Pathology. 178:609-620
Integrins are heterodimeric receptors that regulate cell adhesion, migration, and apoptosis. Integrin αvβ8 is most abundantly expressed in kidney and brain, and its major ligand is latent transforming growth factor-β (TGF-β). Kidney αvβ8 locali
Autor:
George Jarad, Martha Konieczkowski, Carlos A. Obejero-Paz, Amitava Mukherjee, Sujata Lakhe-Reddy, Jeffrey R. Schelling, Karen L. Wu, Shenaz Khan, John R. Sedor
Publikováno v:
Journal of Biological Chemistry. 279:26280-26286
Apoptosis results in cell shrinkage and intracellular acidification, processes opposed by the ubiquitously expressed NHE1 Na(+)/H(+) exchanger. In addition to mediating Na(+)/H(+) transport, NHE1 interacts with ezrin/radixin/moesin (ERM), which tethe
Autor:
John R. Sedor, Sujata Lakhe-Reddy, R. Tyler Miller, Liming Wang, Arthur M. Brown, Jeffrey R. Schelling, Shenaz Khan, Martha Konieczkowski, Karen L. Wu, George Jarad
Publikováno v:
American Journal of Physiology-Renal Physiology. 284:F829-F839
Renal tubular epithelial cell (RTC) apoptosis causes tubular atrophy, a hallmark of renal disease progression. Apoptosis is generally characterized by reduced cell volume and cytosolic pH, but epithelial cells are relatively resistant to shrinkage du
Autor:
Jeffrey R. Schelling, George Jarad, Hui Miao, John R. Sedor, Jay DeVore, Barbara A. Wible, Karen Wu, Martha Konieczkowski, Bingcheng Wang, Stephen L. Nishimura, Shenaz Khan
Publikováno v:
Journal of Biological Chemistry. 277:47826-47833
Cell fate following Fas (CD95) ligand or agonistic anti-Fas antibody stimulation is determined by multiple factors, including Fas expression level, microdomain localization, and modulating cytokines. Highly expressed Fas clusters and activates a cano
Autor:
Jeffrey R. Schelling, Malcolm Hoshi, Raymond C. Harris, Ashraf El-Meanawy, Shenaz Khan, Eckhard Ficker, Isabelle Deschenes, Bassam G. Abu Jawdeh, Monu Goel, Mark D. Parker, Krekwit Shinlapawittayatorn, Satya P. Yadav, William P. Schilling, Michelle Puchowicz
Chronic kidney disease progression can be predicted based on the degree of tubular atrophy, which is the result of proximal tubule apoptosis. The Na+/H+ exchanger NHE1 regulates proximal tubule cell survival through interaction with phosphatidylinosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c605c026becc8e0d9cd6bcb6e4f6efa
https://europepmc.org/articles/PMC3934167/
https://europepmc.org/articles/PMC3934167/