Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shen-Meng Gao"'
Autor:
Hu Lei, Han-Zhang Xu, Hui-Zhuang Shan, Meng Liu, Ying Lu, Zhi-Xiao Fang, Jin Jin, Bo Jing, Xin-Hua Xiao, Shen-Meng Gao, Feng-Hou Gao, Li Xia, Li Yang, Li-Gen Liu, Wei-Wei Wang, Chuan-Xu Liu, Yin Tong, Yun-Zhao Wu, Jun-Ke Zheng, Guo-Qiang Chen, Li Zhou, Ying-Li Wu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Resistance to tyrosine kinase inhibitors (TKI) is a limitation to their use in treating chronic myelogenous leukemia (CML). Here, the authors show that targeting the ubiquitin peptidase USP47 overcomes TKI resistance and eliminates leukaemia stem/pro
Externí odkaz:
https://doaj.org/article/ef7347958ad8427eacd75d192110f022
Autor:
Li Yang, Feng-Hou Gao, Guo-Qiang Chen, Hu Lei, Li Xia, Yin Tong, Zhixiao Fang, Xinhua Xiao, Bo Jing, Huizhuang Shan, Ying-Li Wu, Ligen Liu, Junke Zheng, Jin Jin, Li Zhou, Ying Lu, Chuan-Xu Liu, Meng Liu, Shen-Meng Gao, Weiwei Wang, Hanzhang Xu, Yunzhao Wu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Identifying novel drug targets to overcome resistance to tyrosine kinase inhibitors (TKIs) and eradicating leukemia stem/progenitor cells are required for the treatment of chronic myelogenous leukemia (CML). Here, we show that ubiquitin-specific pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cc5519c0cf19ac771a7a4367ea4933
https://doaj.org/article/ef7347958ad8427eacd75d192110f022
https://doaj.org/article/ef7347958ad8427eacd75d192110f022
Publikováno v:
Asian Pacific Journal of Cancer Prevention. 16:2219-2225
SHP1 negatively regulates the Janus kinase 2/signal transducer and activator of transcription (JAK2/STAT) signaling pathway, which is constitutively activated in myeloproliferative neoplasms (MPNs) and leukemia. Promoter hypermethylation resulting in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4818d1432726a810c48d1e1c2bd632
https://doi.org/10.7314/apjcp.2015.16.6.2219
https://doi.org/10.7314/apjcp.2015.16.6.2219
Autor:
Jianbo Wu, Shen-meng Gao, Chong-yun Xing, Shenghui Zhang, Chi-qi Chen, Junjun Yang, Haiying Li, Lei Jiang
Publikováno v:
Leukemia & Lymphoma. 52:2365-2371
miR-15a and miR-16-1 (miR-15a/16-1) have been implicated in apoptosis, cell cycle regulation and chemosensitivity of tumor cells, but little is known about the role of miR-15a/16-1 in the differentiation of leukemic cells. In this study, we found tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95312f57f4357e6d080a52e7323f42e1
https://doi.org/10.3109/10428194.2011.601476
https://doi.org/10.3109/10428194.2011.601476
Autor:
Fule Wang, Feiyan Lin, Yingxia Tan, Yixiang Han, Shen Meng Gao, Lei Jiang, Chi-qi Chen, Jianbo Wu
Publikováno v:
Cell Biology International. 35:891-896
TIEG1 (TGF-β inducible early gene 1) plays a significant role in regulating cell proliferation and apoptosis in various cell types. Previous studies have shown a close relationship between the expression level of TIEG1 and various cancers, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbca945a41f627f8fd66cae1b8b7c42b
https://doi.org/10.1042/cbi20100896
https://doi.org/10.1042/cbi20100896
Autor:
Shen-meng Gao, Jianbo Wu, Lihui Yin, Chi-qi Chen, Chong-yun Xing, Yanxia Tan, Aifang Ye, Lei Jiang, Kang Yu
Publikováno v:
Biochemical and Biophysical Research Communications. 403:203-208
MicroRNAs (miRNAs) are small noncoding RNAs that regulate target gene expression through translation repression or messenger RNA degradation. MiR-15a and 16-1 form a cluster at the chromosomal region 13q14, which is frequently deleted or down-regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b548a7d798bd393d74c28a4fd55124c9
https://doi.org/10.1016/j.bbrc.2010.10.137
https://doi.org/10.1016/j.bbrc.2010.10.137
Autor:
Min Xu, Man-Gen Song, Shen-Meng Gao, Yuan-Shan Zhu, Yun Yu, Qiong Wang, Zhu Chen, Yu-Hong Zhou, Ke-Ming Du, Guo-Qiang Chen
Publikováno v:
Blood. 105:3714-3721
As a promising new class of anticancer drugs, camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. In the present study, we report that NSC606985, a rarely studied camptothecin analog, induces a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acf6d259b889dea457d94bb018212f1
https://doi.org/10.1182/blood-2004-10-4011
https://doi.org/10.1182/blood-2004-10-4011
Publikováno v:
Journal of cellular biochemistry. 116(2)
Honokiol, a constituent of Magnolia officinalis, has been reported to possess potent anti-cancer activity through targeting multiple signaling pathways in numerous malignancies including acute myeloid leukemia (AML). However, the underlying mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d126cd5c4e1a63d203d996d122e7d94b
https://pubmed.ncbi.nlm.nih.gov/25187418
https://pubmed.ncbi.nlm.nih.gov/25187418
Autor:
Chi-qi Chen, Kang Yu, Qing-xian Yan, Yi Chen, Shen-meng Gao, Chong-yun Xing, Zhuang Yan, Yi-fen Shi, Ke-Wen Zhao
Publikováno v:
Carcinogenesis. 34(7)
Suppressors of cytokine signaling, SOCS1 and SOCS3, are important negative regulators of Janus kinase 2/signal transducers and activators of transcription signaling, which is constitutively activated in myeloproliferative neoplasms (MPNs) and leukemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c523150e772d03e631b456313e91bc
https://pubmed.ncbi.nlm.nih.gov/23430957
https://pubmed.ncbi.nlm.nih.gov/23430957
Autor:
Jianbo Wu, Jun Jun Yang, Lu Yao Wang, Kang Yu, Chi Qi Chen, Chong Yun Xing, Jun Jie Chen, Li Ping Ye, Shen Meng Gao
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 31, Iss 1, p 27 (2012)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Pure curcumin has been reported to down-regulate the expression of WT1 in leukemic cells. However, the molecular mechanism underlying the down-regulation of WT1 by curcumin is not completely delineated. The purpose of this present study is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482a08db72904856246cbe9177a61bc0
https://doi.org/10.1186/1756-9966-31-27
https://doi.org/10.1186/1756-9966-31-27