Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Shen-Hsi Yang"'
Autor:
Ibrahim Ahmed, Shen-Hsi Yang, Samuel Ogden, Wei Zhang, Yaoyong Li, The OCCAMs consortium, Andrew D Sharrocks
Publikováno v:
eLife, Vol 12 (2023)
Cancer is driven by both genetic and epigenetic changes that impact on gene expression profiles and the resulting tumourigenic phenotype. Enhancers are transcriptional regulatory elements that are key to our understanding of how this rewiring of gene
Externí odkaz:
https://doaj.org/article/7d4974e925854dd39070a622ae326f4c
Publikováno v:
F1000Research, Vol 10 (2021)
Many biological studies of transcriptional control mechanisms produce lists of genes and non-coding genomic intervals from corresponding gene expression and epigenomic assays. In higher organisms, such as eukaryotes, genes may be regulated by distal
Externí odkaz:
https://doaj.org/article/ca50e2425dbc43789366f412e4e6f37b
Publikováno v:
F1000Research, Vol 10 (2021)
Many biological studies of transcriptional control mechanisms produce lists of genes and non-coding genomic intervals from corresponding gene expression and epigenomic assays. In higher organisms, such as eukaryotes, genes may be regulated by distal
Externí odkaz:
https://doaj.org/article/a25a1322d0824903aba5ce401a6635b4
Autor:
Shen-Hsi Yang, Munazah Andrabi, Rebecca Biss, Syed Murtuza Baker, Mudassar Iqbal, Andrew D. Sharrocks
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3215-3227.e6 (2019)
Summary: Embryonic stem cells (ESCs) must transition through a series of intermediate cell states before becoming terminally differentiated. Here, we investigated the early events in this transition by determining the changes in the open chromatin la
Externí odkaz:
https://doaj.org/article/d67f3fcb7bde45e9996c0ae97adf3f63
Autor:
Shen-Hsi Yang, Tüzer Kalkan, Claire Morissroe, Hendrik Marks, Hendrik Stunnenberg, Austin Smith, Andrew D. Sharrocks
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1968-1981 (2014)
Embryonic stem cells (ESCs) are unique in that they have the capacity to differentiate into all of the cell types in the body. We know a lot about the complex transcriptional control circuits that maintain the naive pluripotent state under self-renew
Externí odkaz:
https://doaj.org/article/5d756686d44647c4b90b13749a5d7b2c
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003112 (2012)
Embryonic stem cells and induced pluripotent stem cells represent potentially important therapeutic agents in regenerative medicine. Complex interlinked transcriptional and signaling networks control the fate of these cells towards maintenance of plu
Externí odkaz:
https://doaj.org/article/03be84218f5b4a30b5bf0b8ca717c40d
Autor:
Jacqueline C Merrill, Tiffany A Melhuish, Michael H Kagey, Shen-Hsi Yang, Andrew D Sharrocks, David Wotton
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8794 (2010)
Modification of proteins by the small ubiquitin like modifier (SUMO) is an essential process in mammalian cells. SUMO is covalently attached to lysines in target proteins via an enzymatic cascade which consists of E1 and E2, SUMO activating and conju
Externí odkaz:
https://doaj.org/article/3d760fa53bf649029a47b25738bbee37
Autor:
Yaoyong Li, Samantha Carrera, Andrew D. Sharrocks, Karol Nowicki-Osuch, Shen Hsi Yang, Syed Murtuza Baker, David G. Spiller, Amanda O'Donnell
Publikováno v:
Nucleic Acids Research
Carrera, S, O'Donnell, A, Li, Y, Nowicki-Osuch, K, Yang, S-H, Baker, S M, Spiller, D & Sharrocks, A 2021, ' Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters. ', Nucleic Acids Res, vol. 49, no. 22, pp. 12744–12756 . https://doi.org/10.1093/nar/gkab1176
Carrera, S, O'Donnell, A, Li, Y, Nowicki-Osuch, K, Yang, S-H, Baker, S M, Spiller, D & Sharrocks, A 2021, ' Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters. ', Nucleic Acids Res, vol. 49, no. 22, pp. 12744–12756 . https://doi.org/10.1093/nar/gkab1176
High levels of histone acetylation are associated with the regulatory elements of active genes, suggesting a link between acetylation and gene activation. We revisited this model, in the context of EGF-inducible gene expression and found that rather
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e7fc4c68ec6636cda1e4618820f6fa
https://doi.org/10.1093/nar/gkab1176
https://doi.org/10.1093/nar/gkab1176
Publikováno v:
eLife; 3/9/2023, p1-29, 29p
Autor:
Ogden, Samuel, Ahmed, Ibrahim, Shen-Hsi Yang, Fullwood, Paul, Francavilla, Chiara, Sharrocks, Andrew D.
Publikováno v:
NAR Cancer; Mar2023, Vol. 5 Issue 1, p1-14, 14p