Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shen Yon Toh"'
Autor:
Shumei Chia, Joo-Leng Low, Xiaoqian Zhang, Xue-Lin Kwang, Fui-Teen Chong, Ankur Sharma, Denis Bertrand, Shen Yon Toh, Hui-Sun Leong, Matan T. Thangavelu, Jacqueline S. G. Hwang, Kok-Hing Lim, Thakshayeni Skanthakumar, Hiang-Khoon Tan, Yan Su, Siang Hui Choo, Hannes Hentze, Iain B. H. Tan, Alexander Lezhava, Patrick Tan, Daniel S. W. Tan, Giridharan Periyasamy, Judice L. Y. Koh, N. Gopalakrishna Iyer, Ramanuj DasGupta
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Treatment response in patient-derived models may serve as a biomarker for response in the clinic. Here, the authors use paired patient-derived mouse xenografts and patient-derived primary culture models from head and neck squamous cell carcinomas, in
Externí odkaz:
https://doaj.org/article/7f061de7c66f4a4eb132f00dff006462
Autor:
Shen Yon Toh, Jingyi Gong, Guoli Du, John Zhong Li, Shuqun Yang, Jing Ye, Huilan Yao, Yinxin Zhang, Bofu Xue, Qing Li, Hongyuan Yang, Zilong Wen, Peng Li
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2890 (2008)
Fsp27, a member of the Cide family proteins, was shown to localize to lipid droplet and promote lipid storage in adipocytes. We aimed to understand the biological role of Fsp27 in regulating adipose tissue differentiation, insulin sensitivity and ene
Externí odkaz:
https://doaj.org/article/8c8e88bd91f6435981723bed4eb17d5d
Autor:
Patrick Tan, Giridharan Periyasamy, Matan Thangavelu Thangavelu, Judice L. Y. Koh, Hiang Khoon Tan, Shen Yon Toh, Daniel Shao-Weng Tan, Joo-Leng Low, Yan Su, Ankur Sharma, Thakshayeni Skanthakumar, Jacqueline S.G. Hwang, Alexander Lezhava, Iain Beehuat Tan, Hannes Hentze, Hui-Sun Leong, Shumei Chia, N. Gopalakrishna Iyer, Xue-Lin Kwang, Kok-Hing Lim, Xiaoqian Zhang, Ramanuj DasGupta, Siang Hui Choo, Fui-Teen Chong, Denis Bertrand
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
Genomics-driven cancer therapeutics has gained prominence in personalized cancer treatment. However, its utility in indications lacking biomarker-driven treatment strategies remains limited. Here we present a “phenotype-driven precision-oncology”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1661aea700392e21c2c75c5318a7f223
https://doaj.org/article/7f061de7c66f4a4eb132f00dff006462
https://doaj.org/article/7f061de7c66f4a4eb132f00dff006462
Autor:
Zhihong Zhou1, Shen Yon Toh1, Zhengming Chen1, Ke Guo2, Chee Peng Ng3, Sathivel Ponniah4, Sheng-Cai Lin2, Wanjin Hong3, Peng Li1,5 bolipeng@ust.hk
Publikováno v:
Nature Genetics. Sep2003, Vol. 35 Issue 1, p49. 8p.
Autor:
Xiaoqian Zhang, Ramanuj DasGupta, Hui Sun Leong, Prabha Sampath, Shen Yon Toh, Fui Teen Chong, Dawn P. Lau, Daniel Shao-Weng Tan, Mei Kim Ang, N. Gopalakrishna Iyer, Boon Tin Chua, Eng Huat Tan, Gopinath M Sundaram, Wan-Teck Lim, Gek San Tan, Anders Jacobsen Skanderup, Tony Kiat Hon Lim, Xue Lin Kwang, Balram Chowbay, Mei Mei Chang
Publikováno v:
Nature medicine. 23(10)
Targeting EGFR is a validated approach in the treatment of squamous-cell cancers (SCCs), although there are no established biomarkers for predicting response. We have identified a synonymous mutation in EGFR, c.2361G>A (encoding p.Gln787Gln), in two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9cef9ec17346238ff34187c51e4cbb
https://pubmed.ncbi.nlm.nih.gov/28985204
https://pubmed.ncbi.nlm.nih.gov/28985204
Autor:
Xiaoqian Zhang, Ramanuj DasGupta, Daniel Sw Tan, Shen Yon Toh, Xue Lin Kwang, Tony Kh Lim, Anders Jacobsen Skanderup, Fui-Teen Chong, Gek San Tan, Hui-Sun Leong, N. Gopalakrishna Iyer, Dawn P. Lau
Publikováno v:
Cancer Research. 78:2591-2591
Squamous-cell cancers (SCCs) represent one of the commonest lethal malignancy worldwide. Despite evidence demonstrating that majority are addicted to Epidermal Growth Factor Receptor (EGFR)-signaling, targeting with monoclonal antibodies or tyrosine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c90acfa449f5e4d4552c346c7727530
https://doi.org/10.1158/1538-7445.am2018-2591
https://doi.org/10.1158/1538-7445.am2018-2591
Autor:
Jean-Pierre Abastado, Shen Yon Toh, Pingping He, Françoise Thierry, Chai Ling Pang, Yuezhen Xue, Thimothy Lim, Diana Lim
Publikováno v:
Oncotarget
// Yuezhen Xue 1, 5 , Shen Yon Toh 1 , Pingping He 1 , Thimothy Lim 2 , Diana Lim 3 , Chai Ling Pang 4 , Jean-Pierre Abastado 4 , Francoise Thierry 1 1 Institute of Medical Biology, A*STAR, Singapore 2 Department of Gynaecological Oncology, KK Women'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da341e23abb5c036c9c9a71a8111474c
https://pubmed.ncbi.nlm.nih.gov/26474276
https://pubmed.ncbi.nlm.nih.gov/26474276
Autor:
Sathivel Ponniah, Wanjin Hong, Zhihong Zhou, Shen Yon Toh, Chee Peng Ng, Ke Guo, Sheng-Cai Lin, Peng Li, Zhengming Chen
Publikováno v:
Nature Genetics. 35:49-56
The thermogenic activity of brown adipose tissue (BAT), important for adaptive thermogenesis and energy expenditure, is mediated by the mitochondrial uncoupling protein1 (Ucp1) that uncouples ATP generation and dissipates the energy as heat. We show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb684b8e49615a0ccb96d49bdca82105
https://doi.org/10.1038/ng1225
https://doi.org/10.1038/ng1225
Publikováno v:
Biochemical and Biophysical Research Communications. 264:181-185
CAD/DFF40, the nuclease responsible for DNA fragmentation during apoptosis, exists as a heterodimeric complex with DFF45/ICAD. The study presented here augments the accompanying inhibition and chaperone study with an analysis of specific binding stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdd280a6e22c0c60a02e275aef3b27c
https://doi.org/10.1006/bbrc.1999.1498
https://doi.org/10.1006/bbrc.1999.1498
Autor:
Audrey Ann Liew, Daniel Shao-Weng Tan, Tony Kiat Hon Lim, DasGupta Ramanuj, Shen Yon Toh, Eleni G Christodoulou, Dawn Pingxi Lau, Gek San Tan, Sai Sakktee Krisna, Fui Teen Chong, Xue Lin Kwang, Hui Sun Leong, N. Gopalakrishna Iyer, Shivaji Rikka
Publikováno v:
Cancer Research. 76:2109-2109
While EGFR tyrosine kinase inhibitors (TKIs) can elicit significant tumor shrinkage in the clinic, drug resistance inevitably ensues, likely due to a persistent subpopulation. T790M mutation is a common resistance mechanism found in 60% of tumors pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48efb496b828c5be4b0d11c433eb122d
https://doi.org/10.1158/1538-7445.am2016-2109
https://doi.org/10.1158/1538-7445.am2016-2109