Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Shen Y. Heazlewood"'
Autor:
Shen Y. Heazlewood, Tanveer Ahmad, Benjamin Cao, Huimin Cao, Melanie Domingues, Xuan Sun, Chad K. Heazlewood, Songhui Li, Brenda Williams, Madeline Fulton, Jacinta F. White, Tom Nebl, Christian M. Nefzger, Jose M. Polo, Benjamin T. Kile, Felix Kraus, Michael T. Ryan, Yu B. Sun, Peter F. M. Choong, Sarah L. Ellis, Minna-Liisa Anko, Susan K. Nilsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic megakaryocytes (LCM) are critical negative regulators of HSC and criti
Externí odkaz:
https://doaj.org/article/7defb2ab48b547d0b668ad9675392191
Autor:
Xuan Sun, Benjamin Cao, Marina Naval-Sanchez, Tony Pham, Yu Bo Yang Sun, Brenda Williams, Shen Y. Heazlewood, Nikita Deshpande, Jinhua Li, Felix Kraus, James Rae, Quan Nguyen, Hamed Yari, Jan Schröder, Chad K. Heazlewood, Madeline Fulton, Jessica Hatwell-Humble, Kaustav Das Gupta, Ronan Kapetanovic, Xiaoli Chen, Matthew J. Sweet, Robert G. Parton, Michael T. Ryan, Jose M. Polo, Christian M. Nefzger, Susan K. Nilsson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Aged hematopoietic stem cells (HSC) are characterised by reduced regenerative potential and a loss of quiescence. Here, the authors show nicotinamide riboside treatment shrinks the age-enlarged stem cell pool and shifts aged HSC functionally, metabol
Externí odkaz:
https://doaj.org/article/a2cd09ff347c4623848c6acc6789d348
Autor:
Jemma Nicholls, Benjamin Cao, Laetitia Le Texier, Laura Yan Xiong, Christopher R. Hunter, Genesis Llanes, Ethan G. Aguliar, Wayne A. Schroder, Simon Phipps, Jason P. Lynch, Huimin Cao, Shen Y. Heazlewood, Brenda Williams, Andrew D. Clouston, Christian M. Nefzger, Jose M. Polo, Susan K. Nilsson, Bruce R. Blazar, Kelli P. A. MacDonald
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Regulatory T cell (Treg) reconstitution is essential for reestablishing tolerance and maintaining homeostasis following stem-cell transplantation. We previously reported that bone marrow (BM) is highly enriched in autophagy-dependent Treg and autopha
Externí odkaz:
https://doaj.org/article/27d02299a5ee475cab524537e8e3a0b4
Autor:
Shen Y. Heazlewood, Susan K. Nilsson, Kellie Cartledge, Cheang Ly Be, Andrew Vinson, Murat Gel, David N. Haylock
Publikováno v:
Platelets, Vol 28, Iss 7, Pp 649-656 (2017)
Blood transfusion services face an ever-increasing demand for donor platelets to meet clinical needs. Whilst strategies for increasing platelet storage life and improving the efficiency of donor platelet collection are important, in the longer term,
Externí odkaz:
https://doaj.org/article/9061339aaadc46aa813228486f47b931
Autor:
Carolyn A. de Graaf, Jarny Choi, Tracey M. Baldwin, Jessica E. Bolden, Kirsten A. Fairfax, Aaron J. Robinson, Christine Biben, Clare Morgan, Kerry Ramsay, Ashley P. Ng, Maria Kauppi, Elizabeth A. Kruse, Tobias J. Sargeant, Nick Seidenman, Angela D'Amico, Marthe C. D'Ombrain, Erin C. Lucas, Sandra Koernig, Adriana Baz Morelli, Michael J. Wilson, Steven K. Dower, Brenda Williams, Shen Y. Heazlewood, Yifang Hu, Susan K. Nilsson, Li Wu, Gordon K. Smyth, Warren S. Alexander, Douglas J. Hilton
Publikováno v:
Stem Cell Reports, Vol 7, Iss 3, Pp 571-582 (2016)
Hematopoiesis is a multistage process involving the differentiation of stem and progenitor cells into distinct mature cell lineages. Here we present Haemopedia, an atlas of murine gene-expression data containing 54 hematopoietic cell types, covering
Externí odkaz:
https://doaj.org/article/0e4686e0159f47788abe1fd7d9831621
Autor:
Huimin Cao, Benjamin Cao, Chad K. Heazlewood, Melanie Domingues, Xuan Sun, Emmanuel Debele, Narelle E. McGregor, Natalie A. Sims, Shen Y. Heazlewood, Susan K. Nilsson
Publikováno v:
Cells, Vol 8, Iss 9, p 985 (2019)
Osteopontin (OPN) is an important component in both bone and blood regulation, functioning as a bridge between the two. Previously, thrombin-cleaved osteopontin (trOPN), the dominant form of OPN in adult bone marrow (BM), was demonstrated to be a cri
Externí odkaz:
https://doaj.org/article/2a6c5f5e2acd4050a3c24c9230ae1ab9
Autor:
Huimin Cao, Shen Y. Heazlewood, Brenda Williams, Daniela Cardozo, Julie Nigro, Ana Oteiza, Susan K. Nilsson
Publikováno v:
Haematologica, Vol 101, Iss 1 (2016)
Throughout development, hematopoietic stem cells migrate to specific microenvironments, where their fate is, in part, extrinsically controlled. CD44 standard as a member of the cell adhesion molecule family is extensively expressed within adult bone
Externí odkaz:
https://doaj.org/article/783f16b006f9467586096ca451819521
Autor:
Pradnya Gangatirkar, Brenda Williams, Belinda B. Guo, Benjamin Cao, Sarah Ellis, Chad K Heazlewood, Madeline Fulton, Mirana Ramialison, Jacinta F. White, Emma C. Josefsson, Huimin Cao, Tanveer Ahmad, Shen Y. Heazlewood, Madara Ratnadiwakara, Monika Mohenska, Minna-Liisa Änkö, Susan K. Nilsson
Publikováno v:
Blood. 139(9)
RNA processing is increasingly recognized as a critical control point in the regulation of different hematopoietic lineages including megakaryocytes responsible for the production of platelets. Platelets are anucleate cytoplasts that contain a rich r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093f9189998ce9eab59d2c9b78eba02f
https://pubmed.ncbi.nlm.nih.gov/34852174
https://pubmed.ncbi.nlm.nih.gov/34852174
Publikováno v:
The Cancer Stem Cell Niche ISBN: 9780323853255
Acute lymphoblastic leukemia (ALL) remains the most common childhood cancer, and despite the vast improvements to clinical treatments, relapse continues to be associated with high mortality. Incomplete eradication of ALL has been attested to the pers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e92b5948a3fac0a7e2119c90e0d6c39a
https://doi.org/10.1016/bs.asn.2020.11.001
https://doi.org/10.1016/bs.asn.2020.11.001
Publikováno v:
The Stem Cell Niche during Ageing ISBN: 9780128220191
Hematopoietic stem cells (HSC) undergo significant changes during aging, which culminate in an expansion of the stem cell pool, loss of regenerative potential and alterations in lineage differentiation that is skewed toward myeloid cells. While cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16cfca723094d1aa156d26cdded484c0
https://doi.org/10.1016/bs.asn.2020.06.001
https://doi.org/10.1016/bs.asn.2020.06.001