Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Shen Shu Sung"'
Autor:
W. Douglas Cress, Wayne Guida, Harshani Lawrence, Shen-Shu Sung, Sandhya Boyapalle, Courtney A. Kurtyka, Yihong Ma
HLM006474 was identified using a computer-based virtual screen and the known crystal structure of the DNA-bound E2F4/DP2 heterodimer. Treatment of multiple cell lines with HLM006474 resulted in the loss of intracellular E2F4 DNA-binding activity as m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5836b43ebf5da86ddda3f2a01a842ba3
https://doi.org/10.1158/0008-5472.c.6497165
https://doi.org/10.1158/0008-5472.c.6497165
Autor:
W. Douglas Cress, Wayne Guida, Harshani Lawrence, Shen-Shu Sung, Sandhya Boyapalle, Courtney A. Kurtyka, Yihong Ma
Supplementary Figures 1-5, Methods and Materials from A Small-Molecule E2F Inhibitor Blocks Growth in a Melanoma Culture Model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f3bb04bd51ab32918323e90308f035
https://doi.org/10.1158/0008-5472.22373663
https://doi.org/10.1158/0008-5472.22373663
Autor:
Sang Y Lee, Becky Slagle-Webb, Elias Rizk, Akshal Patel, Patti A Miller, Shen-Shu Sung, James R Connor
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108166 (2014)
The standard chemotherapy for brain tumors is temozolomide (TMZ), however, as many as 50% of brain tumors are reportedly TMZ resistant leaving patients without a chemotherapeutic option. We performed serial screening of TMZ resistant astrocytoma cell
Externí odkaz:
https://doaj.org/article/12064bc9895e41299dd79001321b6785
Autor:
Tulin Budak-Alpdogan, Manoj K. Pandey, Krishne Gowda, Sinisa Dovat, Shantu Amin, Thomas Abraham, Shen Shu Sung, Giampolo Talamo
Publikováno v:
Experimental Hematology. 53:31-42
Bruton's tyrosine kinase (BTK) regulates many vital signaling pathways and plays a critical role in cell proliferation, survival, migration, and resistance. Previously, we reported that a small molecule, KS99, is an inhibitor of tubulin polymerizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38a3ba4264b1f03dc41626c3e328fd3
https://doi.org/10.1016/j.exphem.2017.06.003
https://doi.org/10.1016/j.exphem.2017.06.003
Autor:
Shen Shu Sung
Publikováno v:
Protein Science. 26:2003-2009
Recent site-resolved hydrogen exchange measurements have uncovered significant discrepancies between simulations and experimental data during protein folding, including the excessive intramolecular hydrogen bonds in simulations. This finding indicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f235b1456a57e857e3a7d02499cbcdc8
https://doi.org/10.1002/pro.3238
https://doi.org/10.1002/pro.3238
Autor:
Shen Shu Sung
Publikováno v:
Protein Science. 24:1383-1388
Contrary to the widespread view that hydrogen bonding and its entropy effect play a dominant role in protein folding, folding into helical and hairpin-like structures is observed in molecular dynamics (MD) simulations without hydrogen bonding in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::915191a1fd1260aa903a2f4281f85672
https://doi.org/10.1002/pro.2710
https://doi.org/10.1002/pro.2710
Autor:
Thomas P. Loughran, Shen Shu Sung, Mark Kester, Jeremy A. Hengst, Jong K. Yun, Vijay P. Kale, Ashley L. Colledge, Shantu Amin, Arun Sharma, Taryn E. Dick, Hong Gang Wang, Todd E. Fox
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 352:494-508
We previously developed SKI-178 (N′-[(1E)-1-(3,4-dimethoxyphenyl)ethylidene]-3-(4-methoxxyphenyl)-1H-pyrazole-5-carbohydrazide) as a novel sphingosine kinase-1 (SphK1) selective inhibitor and, herein, sought to determine the mechanism-of-action of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eb4245b2e95345ceca24327942e3bb
https://doi.org/10.1124/jpet.114.219659
https://doi.org/10.1124/jpet.114.219659
Autor:
Hong Gang Wang, Christopher M. Dower, Kenichiro Doi, Qiang Liu, Shen Shu Sung, Krishne Gowda, David F. Claxton, Shantu Amin, Jyh Ming Lin, Thomas P. Loughran
Publikováno v:
Cancer Biology & Therapy. 15:1688-1699
Mcl-1, a pro-survival member of the Bcl-2 protein family, is an attractive target for cancer therapy. We have recently identified the natural product marinopyrrole A (maritoclax) as a novel small molecule Mcl-1 inhibitor. Here, we describe the struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85b89f3a997d415897ba86b030a2615
https://doi.org/10.4161/15384047.2014.972799
https://doi.org/10.4161/15384047.2014.972799
Autor:
Shen Shu Sung, Shantu Amin, Giampaolo Talamo, Manoj K. Pandey, Chunhua Song, Arun Sharma, Sinisa Dovat, Vijay P. Kale
Publikováno v:
Experimental Hematology. 42:883-896
Bone disease, characterized by the presence of lytic lesions and osteoporosis is the hallmark of multiple myeloma (MM). Stromal cell-derived factor 1α (SDF-1α) and its receptor, CXC chemokine receptor 4 (CXCR4), has been implicated as a regulator o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a85b445cfe6fd850fef5b9039ce4ec
https://doi.org/10.1016/j.exphem.2014.07.261
https://doi.org/10.1016/j.exphem.2014.07.261
Autor:
Hong Gang Wang, Yoshinori Takahashi, Jorge Becerril, Andrew D. Hamilton, Kenichiro Doi, Norbert Berndt, Jiazhi Sun, Hang Yin, Aslamuzzaman Kazi, Saïd M. Sebti, Shen Shu Sung, Johanna M. Rodriguez
A critical hallmark of cancer cell survival is evasion of apoptosis. This is commonly due to overexpression of anti-apoptotic proteins such as Bcl-2, Bcl-X(L), and Mcl-1, which bind to the BH3 α-helical domain of pro-apoptotic proteins such as Bax,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806f63dc3dea14afb12d697433593f75
https://ora.ox.ac.uk/objects/uuid:a4bbeec4-39ed-4e4c-b795-8690bfae56a1
https://ora.ox.ac.uk/objects/uuid:a4bbeec4-39ed-4e4c-b795-8690bfae56a1