Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shen Mynn Tan"'
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
As the projected incidence and mortality of cancer in Sub-Saharan Africa (SSA) rises to epidemic proportions, it is imperative that more is done to identify the genomic differences and commonalities between patients of African and European ancestry t
Externí odkaz:
https://doaj.org/article/ebd231e736744ce59e604e75766e191b
Autor:
Shen Mynn Tan, Rory Kirchner, Jingmin Jin, Oliver Hofmann, Larry McReynolds, Winston Hide, Judy Lieberman
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1225-1239 (2014)
Identifying microRNA (miRNA)-regulated genes is key to understanding miRNA function. However, many miRNA recognition elements (MREs) do not follow canonical “seed” base-pairing rules, making identification of bona fide targets challenging. Here,
Externí odkaz:
https://doaj.org/article/e10f1682c3fb448092841055b69df2f6
Publikováno v:
Cell Reports, Vol 8, Iss 3, Pp 714-722 (2014)
Tumor suppressor genes (TSGs) are often concomitantly lost or mutated in human cancers and have been shown to act synergistically to promote tumorigenesis. In addition to genomic alterations, posttranscriptional regulation by microRNAs (miRNAs) repre
Externí odkaz:
https://doaj.org/article/74e6797924b34b6d99310795178b3c7c
Publikováno v:
Frontiers in Oncology; 2024, p01-06, 6p
Autor:
Judy Lieberman, Oliver Hofmann, Rory Kirchner, Minh T.N. Le, Haribabu Arthanari, Shunsuke Imai, Elizabeth M. O'Day, Gerhard Wagner, Shen Mynn Tan
Publikováno v:
Journal of Biological Chemistry. 290:17909-17922
Lin28 is an evolutionarily conserved RNA-binding protein that inhibits processing of pre-let-7 microRNAs (miRNAs) and regulates translation of mRNAs that control developmental timing, pluripotency, metabolism, and tumorigenesis. The RNA features that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a5aa5f4430ce12fb95fec15bcc19e0
https://doi.org/10.1074/jbc.m115.665521
https://doi.org/10.1074/jbc.m115.665521
Autor:
Ricky R. Lareu, Haw Siang Ang, Andrew M. Thomson, Henry Yang, Shen Mynn Tan, Winston Hide, Bing Lim, Tian Yun Zhao, Leah A. Vardy, Gabriel Altschuler
Publikováno v:
Nucleic Acids Research
LIN28 function is fundamental to the activity and behavior of human embryonic stem cells (hESCs) and induced pluripotent stem cells. Its main roles in these cell types are the regulation of translational efficiency and let-7 miRNA maturation. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b15b5f868b7728e6f397b0d087ee2fb
https://doi.org/10.1093/nar/gku430
https://doi.org/10.1093/nar/gku430
Autor:
Shen Mynn, Tan, Judy, Lieberman
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1358
MicroRNAs (miRNAs) are small noncoding RNAs that regulate the stability and expression of target RNAs in a sequence-dependent manner. Identifying miRNA-regulated genes is key to understanding miRNA function. Here, we describe an unbiased biochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ebd530a0dd47f87aebcbd399ef10f92
https://pubmed.ncbi.nlm.nih.gov/26463386
https://pubmed.ncbi.nlm.nih.gov/26463386
Publikováno v:
Cell Reports, Vol 8, Iss 3, Pp 714-722 (2014)
SUMMARY Tumor suppressor genes (TSGs) are often concomitantly lost or mutated in human cancers and have been shown to act synergistically to promote tumorigenesis. In addition to genomic alterations, posttranscriptional regulation by microRNAs (miRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcdd59bb61bcf1affca8a4c2dfedb6b
https://europepmc.org/articles/PMC4128194/
https://europepmc.org/articles/PMC4128194/
Autor:
Oliver Hofmann, Jingmin Jin, Judy Lieberman, Shen Mynn Tan, Larry A. McReynolds, Rory Kirchner, Winston Hide
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1225-1239 (2014)
SummaryIdentifying microRNA (miRNA)-regulated genes is key to understanding miRNA function. However, many miRNA recognition elements (MREs) do not follow canonical “seed” base-pairing rules, making identification of bona fide targets challenging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fee510548a718f207950cb5fe41e04
https://pubmed.ncbi.nlm.nih.gov/25131211
https://pubmed.ncbi.nlm.nih.gov/25131211
Autor:
Pier Paolo Pandolfi, Ruth Halaban, Florian A. Karreth, Paolo Provero, Ugo Ala, Pedro A. Perez-Mancera, Dror Weiss, Shen Mynn Tan, Michael Krauthammer, Alistair G. Rust, Gina M. DeNicola, David J. Adams, David A. Tuveson, Kaitlyn A. Webster, Yvonne Tay, Daniele Perna
Publikováno v:
Cell. 147(4)
SummaryWe recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs to regulate mRNA transcripts containing common microRNA recognition elements (MREs). However, the functional role of ceRNAs in cancer remains unknown. Loss of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d572cf3ea0bd466340c3fcd22af1f6b1