Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Shen K. Yang"'
Autor:
Tian Jian Yang, Shen-K. Yang
Publikováno v:
Journal of Food and Drug Analysis. 3
Oxazepam (OX), an anxiolytic drug in clinical use, reacts with ethanol in aqueous and anhydrous ethanol solutions and simulated gastric fluid to form 3-O-ethyloxazepam (EtOX). In simulated gastric fluid containing 30% (by volume) ethanol, approximate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25164712abd7fbe8bf7b2e0c24881d16
https://doi.org/10.38212/2224-6614.3018
https://doi.org/10.38212/2224-6614.3018
Autor:
Xiang-Lin Lu, Shen K. Yang
Publikováno v:
Journal of Food and Drug Analysis. 1
pK(subscript al) values of 3-ethoxy-N-desmethyldiazepam (3-EtO-NDZ) in ethanol and acetonitrile containing various concentrations of sulfuric acid, determined by spectrophotometry and spectropolarimetry, were found to be 3.4 and 0.63 respectively. Te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0501ef09ad768b8f3a573e2bbac6bd94
https://doi.org/10.38212/2224-6614.3037
https://doi.org/10.38212/2224-6614.3037
Autor:
Shen K. Yang, Michael S. Yang
Publikováno v:
Journal of Food and Drug Analysis. 1
Quazepam [7-chloro-1-(N-2,2,2-trifluoroethyl)-5-(2'-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-thione, QZ], an anxiolytic drug in clinical use, was converted in an alkaline solution to form 11 detectable poroducts. 2-Oxoquazepam [7-chloro-1-(N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::658553a13b5085f96a6ee53c9a58cb4b
https://doi.org/10.38212/2224-6614.3071
https://doi.org/10.38212/2224-6614.3071
Autor:
Shen K. Yang
Publikováno v:
Chirality. 11:179-186
Enantiomers of temazepam (TMZ), an anxiolytic drug in clinical use, were resolved and stabilized by the use of aprotic solvents in chiral stationary phase high-performance liquid chromatography (CSP-HPLC). The enantiomers were used to study racemizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcb55e5a674be032cb10a2cb5cafba97
https://doi.org/10.1002/(sici)1520-636x(1999)11:3<179::aid-chir2>3.0.co
https://doi.org/10.1002/(sici)1520-636x(1999)11:3<179::aid-chir2>3.0.co
Autor:
Shen K. Yang
Publikováno v:
Journal of the Chinese Chemical Society. 45:635-642
Diazepam (1) is a frequently prescribed hypnotic/anxiolytic drug worldwide. 7-Chloro-1,3-dihydro-l-methyl-5-phenyl-2H-1,4-benzodiazepin-2,2-dioxide (2) is an initial alkaline hydrolysis product of 1. The mechanisms in the conversion of 2 to 2-methyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49b80f50b18beec7df62db48f0bd301b
https://doi.org/10.1002/jccs.199800096
https://doi.org/10.1002/jccs.199800096
Autor:
Shen K. Yang, Kristopher W. Krausz, Frank J. Gonzalez, Jeroen Buters, Harry V. Gelboin, Magang Shou, Tian J. Yang
Publikováno v:
Biochemical Pharmacology. 55:1633-1640
The human cytochrome P450 2B6 metabolizes, among numerous other substrates, diazepam, 7-ethoxycoumarin, testosterone, and phenanthrene. A recombinant baculovirus containing the human 2B6 cDNA was constructed and used to express 2B6 in Sf9 insect cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbbb34ea866890a7757fd63fb45bb80
https://doi.org/10.1016/s0006-2952(98)00018-5
https://doi.org/10.1016/s0006-2952(98)00018-5
Autor:
Shen K. Yang
Publikováno v:
Journal of the Chinese Chemical Society. 45:277-284
Diazepam (1) is a frequently prescribed hypnotic/anxiolytic drug in worldwide use. Compound 1 is hydrolyzed in alkaline medium to form 2-methylamino-5-chlorobenzophenone imine (2) and 2-methylamino-5-chlorobenzophenone (3); the ratio of 2:3 increases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d5a120a73ed12192af842ea7c83fa63
https://doi.org/10.1002/jccs.199800044
https://doi.org/10.1002/jccs.199800044
Autor:
Shen K. Yang
Publikováno v:
Journal of the Chinese Chemical Society. 44:401-406
The hydrogens at 3-position of diazepam, a frequently prescribed anxiolytic drug worldwide, undergo an efficient exchange with deuterium atoms in alkaline deuterated methanol. The position of deuterium exchange is confirmed by proton nuclear magnetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f25a844c4b79199a4c27f2d4cd3a4c52
https://doi.org/10.1002/jccs.199700060
https://doi.org/10.1002/jccs.199700060
Autor:
Magang Shou, Shen K. Yang
Publikováno v:
Polycyclic Aromatic Compounds. 10:129-136
Racemic 2-hydroxy-3-methylcholanthrene (rac-2-OH-3MC) is a potent carcinogen and 2S-OH-3MC is the most abundant metabolite formed in the metabolism of 3-methylcholanthrene (3MC) by rat liver microsomes. Eighteen identifiable metabolites were formed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe55ca2a9b91d7885a093824d46ee6ab
https://doi.org/10.1080/10406639608034689
https://doi.org/10.1080/10406639608034689
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 38:753-759
The protons at 3-positions of diazepam 4-oxide and nordiazepam 4-oxide underwent an efficient deuterium exchange via keto-enol tautomerism in deuterated alkaline methanol. The 3-dideuterated 4-oxides were each used as a starting material to synthesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0559d34144e200b3d9f9f3815a47ac9
https://doi.org/10.1002/(sici)1099-1344(199608)38:8<753::aid-jlcr890>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199608)38:8<753::aid-jlcr890>3.0.co