Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Shen‐Zhen Ren"'
Publikováno v:
Journal of Drug Targeting. 29:911-924
Today, cancer still poses a serious threat to human, but there is no exact cure. Therefore, exploring to accomplish high therapeutic performance is a challenging and urgent task. Since the nanoparticles unique properties were discovered, they have di
Autor:
Bin Wang, Shu-Kai Li, Hailong An, Hai-Liang Zhu, Ming Liu, Shen-Zhen Ren, Yu-Shun Yang, Xiao-Hua Zhu
Publikováno v:
Journal of Materials Chemistry B. 9:4678-4689
In recent years, the antitumor application of photodynamic therapy (PDT) has gained widespread interest in treating solid tumors. Due to the hypoxic environment in tumors, the major limit of PDT seems to be the source of oxygen. In this work, we atte
Autor:
Song‐Yu Wu, Ya‐Xi Ye, Qing Zhang, Qian‐Jin Kang, Zhu‐Min Xu, Shen‐Zhen Ren, Fan Lin, Yong‐Tao Duan, Hao‐Jun Xu, Zi‐Yi Hu, Sui‐Sui Yang, Hai‐Liang Zhu, Mei‐Juan Zou, Zhong‐Chang Wang
Publikováno v:
Advanced Science. 10:2203742
Photodynamic therapy (PDT) under hypoxic conditions and drug resistance in chemotherapy are perplexing problems in anti-tumor treatment. In addition, central nervous system neoplasm-targeted nanoplatforms are urgently required. To address these issue
Autor:
Yong-Tao Duan, Peng-Wen Chen, Muhammad Abbas, Hai-Liang Zhu, Peng-Cheng Lv, Qi-Xing Liu, Zhong-Chang Wang, Shen-Zhen Ren, Yi Liu, Wu Songyu, Xin Li, Li Zhang
Publikováno v:
European Journal of Medicinal Chemistry. 169:168-184
In this paper, 41 hybrid compounds containing diaryl-1,5-diazole and morpholine structures acting as dual COX-2/5-LOX inhibitors have been designed, synthesized and biologically evaluated. Most of them showed potent antiproliferative activities and C
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Cancer is a major disease burden worldwide. In recent years, in addition to surgical resection, radiotherapy and chemotherapy are recognized as the most effective methods for treating solid tumors. These methods have been introduced to treat tumors o
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 37
Lately, chemotherapy and photodynamic therapy (PDT) synergistic therapy has become a promising anti-cancer treatment mean. However, the hypoxia in tumor leads to huge impediments to the oxygen-dependent PDT effects. In this work, a multifunctional na
Autor:
Yu-Shun Yang, Ming Liu, Shen-Zhen Ren, Hai-Liang Zhu, Bin Wang, Xiao-Hua Zhu, Shu-Kai Li, Dan Zhu, Zhong-Chang Wang
Publikováno v:
ACS applied materialsinterfaces. 12(22)
The abnormal angiogenesis and insufficient oxygen supply in solid tumors lead to intratumoral hypoxia, which severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a multifunctional nanoplatform (ZDZP@PP) based on a zeolitic im
Autor:
Yong-Tao Duan, Jing Zhao, Xiao-Hua Zhu, Shen-Zhen Ren, Hai-Liang Zhu, Zhong-Chang Wang, Dan Zhu, Li Zhang, Han Cao, Fa-Qian Shen
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:4264-4275
The overexpress of COX-2 was clearly associated with carcinogenesis and COX-2 as a possible target has long been exploited for cancer therapy. In this work, we described the design and synthesis of a series of diarylpyrazole derivatives integrating w
Autor:
Qi Liu, Wei-Wei Ni, Shen-Zhen Ren, Hai-Liang Zhu, Peng Cao, He Xiao-Su, Wei-Yi Li, Chen Hui-Min, Jing Yuan, Jia-Jia Liu, Liu Pei, Wei-Kang Shi, Zhu-Ping Xiao, Pu-Zhen Yang
Publikováno v:
European Journal of Medicinal Chemistry. 156:126-136
A novel series of aniline-containing hydroxamic acids were designed, synthesized and evaluated as anti-virulence agents for the treatment of gastritis and gastric ulcer caused by Helicobacter pylori. In vitro enzyme-based screen together with in vivo