IL-1R2-based biomarker models predict melioidosis mortality independent of clinical data

Autor: Taniya Kaewarpai, Shelton W. Wright, Thatcha Yimthin, Rungnapa Phunpang, Adul Dulsuk, Lara Lovelace-Macon, Guilhem F. Rerolle, Denisse B. Dow, Viriya Hantrakun, Nicholas P. J. Day, Ganjana Lertmemongkolchai, Direk Limmathurotsakul, T. Eoin West, Narisara Chantratita

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

IntroductionMelioidosis is an often-fatal tropical infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei, but few studies have identified promising biomarker candidates to predict outcome.MethodsIn 78 prospectively enrolle

Externí odkaz: https://doaj.org/article/df9d05d24996474eb55dd1d477f964a4

sTREM-1 predicts mortality in hospitalized patients with infection in a tropical, middle-income country

Autor: Shelton W. Wright, Lara Lovelace-Macon, Viriya Hantrakun, Kristina E. Rudd, Prapit Teparrukkul, Susanna Kosamo, W. Conrad Liles, Direk Limmathurotsakul, T. Eoin West

Publikováno v: BMC Medicine, Vol 18, Iss 1, Pp 1-9 (2020)

Abstract Background Few studies of biomarkers as predictors of outcome in infection have been performed in tropical, low- and middle-income countries where the burden of sepsis is highest. We evaluated whether selected biomarkers could predict 28-day

Externí odkaz: https://doaj.org/article/8e1713ab441743789d1b3176a0cbae46

Lactoferrin is a dynamic protein in human melioidosis and is a TLR4-dependent driver of TNF-α release in Burkholderia thailandensis infection in vitro.

Autor: Shelton W Wright, Lara Lovelace-Macon, Deirdre Ducken, Sarunporn Tandhavanant, Prapit Teparrukkul, Viriya Hantrakun, Direk Limmathurotsakul, Narisara Chantratita, T Eoin West

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008495 (2020)

Melioidosis is an often-severe tropical infection caused by Burkholderia pseudomallei (Bp) with high associated morbidity and mortality. Burkholderia thailandensis (Bt) is a closely related surrogate that does not require BSL-3 conditions for study.

Externí odkaz: https://doaj.org/article/19ccb44010cb46a78d0da2c85813eaed

Prognostic Accuracy of Screening Tools for Clinical Deterioration in Adults With Suspected Sepsis in Northeastern Thailand: A Cohort Validation Study.

Autor: Wixon-Genack, Jenna¹ (AUTHOR), Wright, Shelton W² (AUTHOR) shelwi@uw.edu, Ortega, Natalie L Cobb³ (AUTHOR), Hantrakun, Viriya⁴ (AUTHOR), Rudd, Kristina E⁵ (AUTHOR), Teparrukkul, Prapit⁶ (AUTHOR), Limmathurotsakul, Direk^4,7 (AUTHOR), West, T Eoin³ (AUTHOR) shelwi@uw.edu

Publikováno v: Open Forum Infectious Diseases. May2024, Vol. 11 Issue 5, p1-7. 7p.

NWChem: Past, Present, and Future

Autor: Aprà, E., Bylaska, E. J., de Jong, W. A., Govind, N., Kowalski, K., Straatsma, T. P., Valiev, M., van Dam, H. J. J., Alexeev, Y., Anchell, J., Anisimov, V., Aquino, F. W., Atta-Fynn, R., Autschbach, J., Bauman, N. P., Becca, J. C., Bernholdt, D. E., Bhaskaran-Nair, K., Bogatko, S., Borowski, P., Boschen, J., Brabec, J., Bruner, A., Cauët, E., Chen, Y., Chuev, G. N., Cramer, C. J., Daily, J., Deegan, M. J. O., Dunning Jr., T. H., Dupuis, M., Dyall, K. G., Fann, G. I., Fischer, S. A., Fonari, A., Früuchtl, H., Gagliardi, L., Garza, J., Gawande, N., Ghosh, S., Glaesemann, K., Götz, A. W., Hammond, J., Helms, V., Hermes, E. D., Hirao, K., Hirata, S., Jacquelin, M., Jensen, L., Johnson, B. G., Jónsson, H., Kendall, R. A., Klemm, M., Kobayashi, R., Konkov, V., Krishnamoorthy, S., Krishnan, M., Lin, Z., Lins, R. D., Littlefield, R. J., Logsdail, A. J., Lopata, K., Ma, W., Marenich, A. V., del Campo, J. Martin, Mejia-Rodriguez, D., Moore, J. E., Mullin, J. M., Nakajima, T., Nascimento, D. R., Nichols, J. A., Nichols, P. J., Nieplocha, J., de la Roza, A. Otero, Palmer, B., Panyala, A., Pirojsirikul, T., Peng, B., Peverati, R., Pittner, J., Pollack, L., Richard, R. M., Sadayappan, P., Schatz, G. C., Shelton, W. A., Silverstein, D. W., Smith, D. M. A., Soares, T. A., Song, D., Swart, M., Taylor, H. L., Thomas, G. S., Tipparaju, V., Truhlar, D. G., Tsemekhman, K., Van Voorhis, T., Vázquez-Mayagoitia, Á., Verma, P., Villa, O., Vishnu, A., Vogiatzis, K. D., Wang, D., Weare, J. H., Williamson, M. J., Windus, T. L., Woliński, K., Wong, A. T., Wu, Q., Yang, C., Yu, Q., Zacharias, M., Zhang, Z., Zhao, Y., Harrison, R. J.

Publikováno v: J. Chem. Phys., 152, 184102 (2020)

Specialized computational chemistry packages have permanently reshaped the landscape of chemical and materials science by providing tools to support and guide experimental efforts and for the prediction of atomistic and electronic properties. In this

Externí odkaz: http://arxiv.org/abs/2004.12023