The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis.

Autor: Branchford BR; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA.; University of Colorado Hemophilia and Thrombosis Center, Aurora, CO, USA., Stalker TJ; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Law L; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA., Acevedo G; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA., Sather S; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA., Brzezinski C; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA., Wilson KM; Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Minson K; Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, USA.; Department of Pediatrics, Section of Hematology/Oncology, Emory University School of Medicine, Atlanta, GA, USA., Lee-Sherick AB; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA., Davizon-Castillo P; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA., Ng C; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA.; University of Colorado Hemophilia and Thrombosis Center, Aurora, CO, USA., Zhang W; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Neeves KB; Department of Chemical & Biological Engineering, Colorado School of Mines, Golden, CO, USA., Lentz SR; Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Wang X; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Frye SV; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Shelton Earp H 3rd; Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., DeRyckere D; Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, USA.; Department of Pediatrics, Section of Hematology/Oncology, Emory University School of Medicine, Atlanta, GA, USA., Brass LF; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Graham DK; Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, USA.; Department of Pediatrics, Section of Hematology/Oncology, Emory University School of Medicine, Atlanta, GA, USA., Di Paola JA; Department of Pediatrics, Section of Hematology/Oncology, University of Colorado School of Medicine, Aurora, CO, USA.; University of Colorado Hemophilia and Thrombosis Center, Aurora, CO, USA.; Graduate Program - Human Medical Genetics, University of Colorado School of Medicine, Aurora, CO, USA.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2018 Feb; Vol. 16 (2), pp. 352-363. Date of Electronic Publication: 2018 Jan 12.