Výsledky vyhledávání - "Shelly T. Jones"

Hyperexcitability in the olfactory bulb and impaired fine odor discrimination in the Fmr1 KO mouse model of fragile X syndrome

Autor: Praveen Kuruppath, Lin Xue, Frederic Pouille, Shelly T. Jones, Nathan E. Schoppa

Publikováno v: bioRxiv

Fragile X syndrome (FXS) is the single most common monogenetic cause of autism spectrum disorders in humans. FXS is caused by loss of expression of the Fragile X mental retardation protein (FMRP), an mRNA-binding protein encoded on the X chromosome i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761518b411b8467bafe9f0e48d33b2f6
https://europepmc.org/articles/PMC10120685/

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Akademický článek

Positive Allosteric Modulation of Kv Channels by Sevoflurane: Insights into the Structural Basis of Inhaled Anesthetic Action.

Autor: Qiansheng Liang, Warren D Anderson, Shelly T Jones, Caio S Souza, Juliana M Hosoume, Werner Treptow, Manuel Covarrubias

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143363 (2015)

Inhalational general anesthesia results from the poorly understood interactions of haloethers with multiple protein targets, which prominently includes ion channels in the nervous system. Previously, we reported that the commonly used inhaled anesthe

Externí odkaz: https://doaj.org/article/3647a0ae72b24cc286f58ccdf85b4c1c

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Positive Allosteric Modulation of Kv Channels by Sevoflurane: Insights into the Structural Basis of Inhaled Anesthetic Action

Autor: Caio S. Souza, Werner Treptow, Juliana Hosoume, Qiansheng Liang, Manuel Covarrubias, Shelly T. Jones, Warren D. Anderson

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143363 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ea5908ecc5e29bad0b3d8516a0ecd2
https://doi.org/10.1371/journal.pone.0143363

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Sevoflurane Potentiates Kv Channels by Inhibiting a Late Non-Conducting State: A Plausible Mechanism of General Anesthetic Action Implicating the Selectivity Filter

Autor: Caio S. Souza, Leticia Stock, Werner Treptow, Shelly T. Jones, Manuel Covarrubias, Juliana Hosoume

Publikováno v: Biophysical Journal. (2):281a

Previous work has shown that sevoflurane potentiates gating of Kv channels, including mammalian Kv1.2, Kv1.5 and Drosophila K-Shaw2 (J Biol Chem, 287: 40425-0432, 2012). Kinetic modeling additionally showed that this potentiation could result from th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e160bbb8b48875af14040ea35cab661

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