Výsledky vyhledávání - "Shelly Kaushik"

Abstract 2791: Biomarker strategy for a phase 1 study of ORIC-944, a potent and selective allosteric PRC2 inhibitor, in patients with metastatic prostate cancer

Autor: Anneleen Daemen, Natalie Yuen, Aleksandr Pankov, Eric A. Ariazi, Subhash D. Katewa, Frank L. Duong, Amber Wang, Shravani Barkund, Shelly Kaushik, Jessica D. Sun, Lori S. Friedman, Melissa R. Junttila

Publikováno v: Cancer Research. 83:2791-2791

Background: Polycomb repressive complex 2 (PRC2) tri-methylates histone H3 at lysine 27 (H3K27me3) leading to transcriptionally silenced genes. ORIC-944 is a potent, highly selective allosteric small molecule inhibitor of PRC2’s embryonic ectoderm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fca7199d3c83e56fde9583bdece4140
https://doi.org/10.1158/1538-7445.am2023-2791

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Abstract 1131: ORIC-944, a potent and selective allosteric PRC2 inhibitor, demonstrates robust in vivo activity in prostate cancer models

Autor: James G. Christensen, Anneleen Daemen, Melissa R. Junttila, Frank Duong, Aaron C. Burns, Aleksandr Pankov, Jessica Sun, Andrew Calinisan, Shravani Barkund, Natalie Yuen, John M. Ketcham, Jae H. Chang, Niranjan Sudhakar, Shelly Kaushik, Peter D. Olson, David Briere, Matthew A. Marx, Lori Friedman

Publikováno v: Cancer Research. 81:1131-1131

The polycomb repressive complex 2 (PRC2) is responsible for the methylation of histone 3 at lysine 27 (H3K27) which leads to long-term transcriptional silencing. Through this epigenetic chromatin silencing mechanism, PRC2 plays a key role in regulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6819cfb7be95ab8c86d8274214e86377
https://doi.org/10.1158/1538-7445.am2021-1131

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Development of a facile antibody–drug conjugate platform for increased stability and homogeneity

Autor: Samad Hossain, Jwala Sivaccumar, Nimish Gupta, Shiladitya Sengupta, Aasif Ansari, Ravinder Goyal, Arindam Sarkar, Manoj K. Pandey, Johny Kancharla, Shelly Kaushik, Monideepa Roy, Aniruddha Sengupta, Sajid Hussain, Swadhin K. Mandal

Publikováno v: Chemical Science. 8:2387-2395

Despite the advances in the design of antibody–drug conjugates (ADCs), the search is still ongoing for novel approaches that lead to increased stability and homogeneity of the ADCs. We report, for the first time, an ADC platform technology using a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51cdb86d24305b3ae284baeaad64ce37
https://doi.org/10.1039/c6sc05149a

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Unlocking the Dangers of a Stiffening Brain

Autor: Shelly Kaushik, Anders Persson

Publikováno v: Neuron. 100:763-765

Mechanical cues regulate neuronal function and reactivity of glial cells, the origin of gliomas. In this issue of Neuron, Chen et al. (2018) uncover a feedforward loop mediated by the mechanosensitive ion channel Piezo1 and tissue stiffness that driv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83295cde5df68ec24acd68b0db5ec11
https://doi.org/10.1016/j.neuron.2018.11.011

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Tissue mechanics, an important regulator of development and disease

Autor: Valerie M. Weaver, Shelly Kaushik, Nadia M. E. Ayad

Publikováno v: Philos Trans R Soc Lond B Biol Sci

A growing body of work describes how physical forces in and around cells affect their growth, proliferation, migration, function and differentiation into specialized types. How cells receive and respond biochemically to mechanical signals is a proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f23cb15fe6102ec08097993a50f46b
https://pubmed.ncbi.nlm.nih.gov/31431174

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Epidermal Growth Factor Activates the Rho GTPase-activating Protein (GAP) Deleted in Liver Cancer 1 via Focal Adhesion Kinase and Protein Phosphatase 2A

Autor: Catherine Qiurong Pan, Boon Chuan Low, Aarthi Ravichandran, Archna Ravi, Shelly Kaushik

Publikováno v: Journal of Biological Chemistry. 290:4149-4162

Deleted in Liver Cancer 1 (DLC1) is a RHO GTPase-activating protein (GAP) that negatively regulates RHO. Through its GAP activity, it modulates the actin cytoskeleton network and focal adhesion dynamics, ultimately leading to suppression of cell inva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b3c7c016360b33214d920e3a451c30
https://doi.org/10.1074/jbc.m114.616839

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Concerted modulation of paxillin dynamics at focal adhesions by deleted in liver cancer-1 and focal adhesion kinase during early cell spreading

Autor: Boon Chuan Low, Feroz M. Hameed, Shelly Kaushik, Archna Ravi

Publikováno v: Cytoskeleton. 71:677-694

Deleted in Liver Cancer-1 (DLC1) is a RhoGTPase-activating protein (GAP) and a tumor suppressor often downregulated in cancers. It is localized to the focal adhesions (FAs) and its absence leads to enhanced cell migration, invasion, and metastasis. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e15613ea278c382f3e965d315d0f82e0
https://doi.org/10.1002/cm.21201

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From transformation to metastasis: deconstructing the extracellular matrix in breast cancer

Autor: Valerie M. Weaver, Michael W. Pickup, Shelly Kaushik

Publikováno v: Cancer metastasis reviews, vol 35, iss 4

The extracellular matrix (ECM) is a guiding force that regulates various developmental stages of the breast. In addition to providing structural support for the cells, it mediates epithelial-stromal communication and provides cues for cell survival,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35e0eb299376d1c9c0688e5c5b22f8e
https://pubmed.ncbi.nlm.nih.gov/27914000

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TMIC-43. A TENSION-MEDIATED GLYCOCALYX FEEDBACK LOOP PROMOTES A MESENCHYMAL, STEM-LIKE PHENOTYPE IN GLIOBLASTOMA

Autor: Valerie M. Weaver, Joanna J. Phillips, Jonathon N. Lakins, Laralynne Przybyla, James Matthew Barnes, Do-Hyun Nam, Carolyn R. Bertozzi, FuiBoon Kai, Shelly Kaushik, Elliot C. Woods, Jason K. Sa, Russell Bainer

Publikováno v: Neuro-Oncology. 20:vi265-vi266

Glioblastoma multiforme (GBM) is one of the deadliest central nervous system cancers, difficult to treat and largely impossible to cure. A considerable challenge in GBM therapy is treatment resistance and tumor recurrence, resulting in dismal patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2dd7d56252925ad3f28841c48c8a6f5
https://doi.org/10.1093/neuonc/noy148.1102

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Abstract 1900: A tension-mediated glycocalyx feedback loop promotes glioblastoma

Autor: Shelly Kaushik, James Matthew Barnes, Russell O. Bainer, Jason K. Sa, Elliot C. Woods, Fuiboon Kai, Jonathon N. Lakins, Joanna J. Phillips, Valerie M. Weaver

Publikováno v: Cancer Research. 79:1900-1900

A considerable challenge in glioblastoma (GBM) therapy is treatment resistance and tumor recurrence, resulting in dismal patient prognosis. GBM aggression and recurrence is often associated with a mesenchymal phenotype, increased expression of glycop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::662f29919928f1a12e7742764ec3d606
https://doi.org/10.1158/1538-7445.am2019-1900

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