Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Shelly B. Flagel"'
Autor:
Janna M. Colaizzi, Shelly B. Flagel, Ashley N. Gearhardt, Michelle A. Borowitz, Rayus Kuplicki, Vadim Zotev, Grace Clark, Jennifer Coronado, Talia Abbott, Martin P. Paulus
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Externalizing behaviors in childhood often predict impulse control disorders in adulthood; however, the underlying bio-behavioral risk factors are incompletely understood. In animals, the propensity to sign-track, or the degree to which ince
Externí odkaz:
https://doaj.org/article/3028d404568d45ca89a41087e45ec253
Autor:
Sarah N. Wright, Brittany S. Leger, Sara Brin Rosenthal, Sophie N. Liu, Tongqiu Jia, Apurva S. Chitre, Oksana Polesskaya, Katie Holl, Jianjun Gao, Riyan Cheng, Angel Garcia Martinez, Anthony George, Alexander F. Gileta, Wenyan Han, Alesa H. Netzley, Christopher P. King, Alexander Lamparelli, Connor Martin, Celine L. St. Pierre, Tengfei Wang, Hannah Bimschleger, Jerry Richards, Keita Ishiwari, Hao Chen, Shelly B. Flagel, Paul Meyer, Terry E. Robinson, Leah C. Solberg Woods, Jason F. Kreisberg, Trey Ideker, Abraham A. Palmer
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112873- (2023)
Summary: A vexing observation in genome-wide association studies (GWASs) is that parallel analyses in different species may not identify orthologous genes. Here, we demonstrate that cross-species translation of GWASs can be greatly improved by an ana
Externí odkaz:
https://doaj.org/article/40d23e0993024b1ea31e653650c9f892
Autor:
Apurva S. Chitre, Elaine K. Hebda-Bauer, Peter Blandino, Hannah Bimschleger, Khai-Minh Nguyen, Pamela Maras, Fei Li, A. Bilge Ozel, Yanchao Pan, Oksana Polesskaya, Riyan Cheng, Shelly B. Flagel, Stanley J. Watson, Jun Li, Huda Akil, Abraham A. Palmer
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Common genetic factors likely contribute to multiple psychiatric diseases including mood and substance use disorders. Certain stable, heritable traits reflecting temperament, termed externalizing or internalizing, play a large role in modulating vuln
Externí odkaz:
https://doaj.org/article/b0175e27439b4411910c8a5f75b7f566
Autor:
Aram Parsegian, M. Julia García-Fuster, Elaine Hebda-Bauer, Stanley J. Watson, Shelly B. Flagel, Huda Akil
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Adolescent drug use reliably predicts increased addiction liability in adulthood, but not all individuals are equally impacted. To explore the biological bases of this differential reactivity to early life drug experience, we used a genetic rat model
Externí odkaz:
https://doaj.org/article/4fb0b1fc3c324177a44c15ff262798f9
Autor:
Christopher P. King, Jordan A. Tripi, Alesa R. Hughson, Aidan P. Horvath, Alexander C. Lamparelli, Katie L. Holl, Apurva S. Chitre, Oksana Polesskaya, Keita Ishiwari, Leah C. Solberg Woods, Abraham A. Palmer, Terry E. Robinson, Shelly B. Flagel, Paul J. Meyer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Sensitivity to cocaine and its associated stimuli (“cues”) are important factors in the development and maintenance of addiction. Rodent studies suggest that this sensitivity is related, in part, to the propensity to attribute incentive
Externí odkaz:
https://doaj.org/article/1966665f7b7c41679e07bd86e26a9015
Autor:
Amanda G. Iglesias, Shelly B. Flagel
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 15 (2021)
In this review, we highlight evidence that supports a role for the paraventricular nucleus of the thalamus (PVT) in motivated behavior. We include a neuroanatomical and neurochemical overview, outlining what is known of the cellular makeup of the reg
Externí odkaz:
https://doaj.org/article/6334940c54ed4d859ed4f7a11b9cbae5
Autor:
Alexander F Gileta, Christopher J Fitzpatrick, Apurva S Chitre, Celine L St Pierre, Elizabeth V Joyce, Rachael J Maguire, Africa M McLeod, Natalia M Gonzales, April E Williams, Jonathan D Morrow, Terry E Robinson, Shelly B Flagel, Abraham A Palmer
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010234 (2022)
Sprague Dawley (SD) rats are among the most widely used outbred laboratory rat populations. Despite this, the genetic characteristics of SD rats have not been clearly described, and SD rats are rarely used for experiments aimed at exploring genotype-
Externí odkaz:
https://doaj.org/article/981971953836450d8c94637971471c7b
Autor:
Amanda G. Iglesias, Alvin S. Chiu, Jason Wong, Paolo Campus, Fei Li, Zitong (Nemo) Liu, Shiv A. Patel, Karl Deisseroth, Huda Akil, Christian R. Burgess, Shelly B. Flagel
Publikováno v:
bioRxiv
The survival of an organism is dependent on their ability to respond to cues in the environment. Such cues can attain control over behavior as a function of the value ascribed to them. Some individuals have an inherent tendency to attribute reward-pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ddc1837256f28cd0a679b917af3bac
https://europepmc.org/articles/PMC10187226/
https://europepmc.org/articles/PMC10187226/
Autor:
Paolo Campus, Ignacio R Covelo, Youngsoo Kim, Aram Parsegian, Brittany N Kuhn, Sofia A Lopez, John F Neumaier, Susan M Ferguson, Leah C Solberg Woods, Martin Sarter, Shelly B Flagel
Publikováno v:
eLife, Vol 8 (2019)
Cues in the environment can elicit complex emotional states, and thereby maladaptive behavior, as a function of their ascribed value. Here we capture individual variation in the propensity to attribute motivational value to reward-cues using the sign
Externí odkaz:
https://doaj.org/article/fda98ee97227493e80cc50c7bf11e596
Autor:
Apurva S Chitre, Oksana Polesskaya, Daniel Munro, Riyan Cheng, Pejman Mohammadi, Katie Holl, Jianjun Gao, Hannah Bimschleger, Angel Garcia Martinez, Anthony M George, Alexander F Gileta, Wenyan Han, Aidan Horvath, Alesa Hughson, Keita Ishiwari, Christopher P King, Alexander Lamparelli, Cassandra L Versaggi, Connor D Martin, Celine L St. Pierre, Jordan A Tripi, Jerry B Richards, Tengfei Wang, Hao Chen, Shelly B Flagel, Paul Meyer, Terry E Robinson, Leah C Solberg Woods, Abraham A Palmer
Publikováno v:
GENETICS. 224
Power analyses are often used to determine the number of animals required for a genome-wide association study (GWAS). These analyses are typically intended to estimate the sample size needed for at least 1 locus to exceed a genome-wide significance t