Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Shelley L, Berger"'
Autor:
Chen Wang, Hideki Tanizawa, Connor Hill, Aaron Havas, Qiang Zhang, Liping Liao, Xue Hao, Xue Lei, Lu Wang, Hao Nie, Yuan Qi, Bin Tian, Alessandro Gardini, Andrew V. Kossenkov, Aaron Goldman, Shelley L. Berger, Ken-ichi Noma, Peter D. Adams, Rugang Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m6A modification to regulate gene expression. In addition, METTL3 regulates transcription in an enzymatic activity-independent manner by driving changes in high
Externí odkaz:
https://doaj.org/article/510df8c88f934aa994ca58141deaa581
Autor:
Daniel C. Xu, Hanna Sas-Nowosielska, Greg Donahue, Hua Huang, Naemeh Pourshafie, Charly R. Good, Shelley L. Berger
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-19 (2024)
Abstract Alzheimer’s Disease (AD) is a disorder characterized by cognitive decline, neurodegeneration, and accumulation of amyloid plaques and tau neurofibrillary tangles in the brain. Dysregulation of epigenetic histone modifications may lead to e
Externí odkaz:
https://doaj.org/article/d4a97795b4ba4111b36dc1d05af979dc
Autor:
Bianca Y. Pingul, Hua Huang, Qingzhou Chen, Fatemeh Alikarami, Zhen Zhang, Jun Qi, Kathrin M. Bernt, Shelley L. Berger, Zhendong Cao, Junwei Shi
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105139- (2022)
Summary: Transcriptional dysregulation is a prominent feature in leukemia. Here, we systematically surveyed transcription factor (TF) vulnerabilities in leukemia and uncovered TF clusters that exhibit context-specific vulnerabilities within and betwe
Externí odkaz:
https://doaj.org/article/58972fc9185b4fbda1cc3707f7bb0eaf
Autor:
Marion Crespo, Lacey J. Luense, Marie Arlotto, Jialei Hu, Jean Dorsey, Encar García-Oliver, Parisha P. Shah, Delphine Pflieger, Shelley L. Berger, Jérôme Govin
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-23 (2020)
Abstract Background Gametes are highly differentiated cells specialized to carry and protect the parental genetic information. During male germ cell maturation, histone proteins undergo distinct changes that result in a highly compacted chromatin org
Externí odkaz:
https://doaj.org/article/63b9cbeb712f42c1b2b96fe0dd57f7a0
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009801 (2021)
A key question in the rising field of neuroepigenetics is how behavioral plasticity is established and maintained in the developing CNS of multicellular organisms. Behavior is controlled through systemic changes in hormonal signaling, cell-specific r
Externí odkaz:
https://doaj.org/article/091c4f39037a43fabe0f5ac2ad203492
Autor:
John Kee, Samuel Thudium, David M. Renner, Karl Glastad, Katherine Palozola, Zhen Zhang, Yize Li, Yemin Lan, Joseph Cesare, Andrey Poleshko, Anna A. Kiseleva, Rachel Truitt, Fabian L. Cardenas-Diaz, Xianwen Zhang, Xuping Xie, Darrell N. Kotton, Konstantinos D. Alysandratos, Jonathan A. Epstein, Pei-Yong Shi, Wenli Yang, Edward Morrisey, Benjamin A. Garcia, Shelley L. Berger, Susan R. Weiss, Erica Korb
Publikováno v:
Nature. 610:381-388
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID-19), in part because of its ability to effectively suppress host cell responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14f93578df8cf1d1aa03f64761eefec
https://doi.org/10.1038/s41586-022-05282-z
https://doi.org/10.1038/s41586-022-05282-z
Autor:
Gregory M. Pask, Jesse D. Slone, Jocelyn G. Millar, Prithwiraj Das, Jardel A. Moreira, Xiaofan Zhou, Jan Bello, Shelley L. Berger, Roberto Bonasio, Claude Desplan, Danny Reinberg, Jürgen Liebig, Laurence J. Zwiebel, Anandasankar Ray
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Cuticular hydrocarbons (CHC) mediate the interactions between individuals in eusocial insects, but the sensory receptors for CHCs are unclear. Here the authors show that in ants such as H. saltator, the 9-exon subfamily of odorant receptors (HsOrs) r
Externí odkaz:
https://doaj.org/article/cda7bbb821e143f7b50ef1864ea66992
Autor:
Majid Ghaninia, Kevin Haight, Shelley L. Berger, Danny Reinberg, Laurence J. Zwiebel, Anandasankar Ray, Jürgen Liebig
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Insects communicate with pheromones using sensitive antennal sensilla. Although trace amounts of pheromones can be detected by many insects, context-dependent increased costs of high sensitivity might lead to plasticity in sensillum responsi
Externí odkaz:
https://doaj.org/article/d33dc11fd9da4f26adf49f793f1f5caa
Publikováno v:
Genes & Development.
Eusocial insect reproductive females show strikingly longer life spans than nonreproductive female workers despite high genetic similarity. In the antHarpegnathos saltator(Hsal), workers can transition to reproductive “gamergates,” acquiring a fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8688110bb6998a89e33e2fab5b369431
https://doi.org/10.1101/gad.350250.122
https://doi.org/10.1101/gad.350250.122
Autor:
Lu Wang, Gregory Donahue, Chen Zhang, Aaron Havas, Xue Lei, Caiyue Xu, Wenliang Wang, Golnaz Vahedi, Peter D. Adams, Shelley L. Berger
Publikováno v:
bioRxiv
SummaryGene expression programs are regulated by enhancers which act in a context-specific manner, and can reside at great distances from their target genes. Extensive three-dimensional (3D) genome reorganization occurs in senescence, but how enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce22ee9f9e9f64e694363b307ab6c916
https://doi.org/10.1101/2023.05.22.541769
https://doi.org/10.1101/2023.05.22.541769
