Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shelley K. Gleason"'
Autor:
Shirley Li, Kelly M. George, Shelley K. Gleason, Charles Wartchow, Binh Thanh Vu, Hong Qian, Ann C. Petersen, Qing-Fen Gan, Lin Gao, Gabriel Stephen Deems, Linghao Niu, Nanda Beatini, Johannes C. Hermann, Arjun Narayanan, John Menke, Nathan Robert Scott, Nancy-Ellen Haynes, Yingsi Chen
Publikováno v:
ACS Medicinal Chemistry Letters. 4:197-200
Organic impurities in compound libraries are known to often cause false-positive signals in screening campaigns for new leads, but organic impurities do not fully account for all false-positive results. We discovered inorganic impurities in our scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ba9438c9107f86a17a7e7700489491
https://doi.org/10.1021/ml3003296
https://doi.org/10.1021/ml3003296
Autor:
Zongxing Qiu, Julie Qi Hang, Taraneh Mirzadegan, Xianfeng Lin, Gabrielle Heilek, Pete William Dunten, Zhanguo Wang, Denis John Kertesz, Klaus Klumpp, Shelley K. Gleason, Seth F. Harris, Christine E. Brotherton-Pleiss, Donald Roy Hirschfeld, Armando G. Villaseñor, Minmin Yang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4215-4218
Further investigation of the recently reported piperidine-4-yl-aminopyrimidine class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) has been carried out. Thus, preparation of a series of N-phenyl piperidine analogs resulted in the identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e4a364fceb7b96160b1a871111841c
https://doi.org/10.1016/j.bmcl.2010.05.040
https://doi.org/10.1016/j.bmcl.2010.05.040
Autor:
Cheng-I. Mau, Andreas Jekle, Ferenc Makra, Surya Sankuratri, Paul Weller, André deRosier, Eun Kyung Lee, Gabriel Stephen Deems, Gabrielle Heilek, David Mark Rotstein, Changhua Ji, Shelley K. Gleason, Christine E. Brotherton-Pleiss, Marianna Dioszegi, Lubov Filonova, Lina Setti, Pamela Berry, Alejandra Trejo-Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5401-5406
A novel series of CCR5 antagonists has been identified, utilizing leads from high-throughput screening which were further modified based on insights from competitor molecules. Lead optimization was pursued by balancing opposing trends of metabolic st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a12820458536333a16236817f9aa665
https://doi.org/10.1016/j.bmcl.2009.07.122
https://doi.org/10.1016/j.bmcl.2009.07.122
Autor:
Jennifer Fretland, Jeffrey Wu, Nidhi Arora, Fang‐Jie Zhang, Julie Q. Hang, Judy M. Suh, Stan Tsing, Seth F. Harris, Joshua Kennedy-Smith, Amber Paul, James Edward Paul Davidson, Sarah Sperry, J. Roland Billedeau, Mark D. Smith, Gabrielle Heilek, Klaus Klumpp, Guoping Su, Zachary Kevin Sweeney, Hassan Javanbakht, Amy S. Zhou, Taraneh Mirzadegan, Shelley K. Gleason, Yu Li, Ralf Roetz, Jesper A. Jernelius, Donald Roy Hirschfeld, Armando G. Villaseñor
Publikováno v:
Journal of Medicinal Chemistry. 51:7449-7458
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are recommended components of preferred combination antiretroviral therapies used for the treatment of HIV. These regimens are extremely effective in suppressing virus replication. Structure-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9dd621d2388ac4c08151f4728547da
https://doi.org/10.1021/jm800527x
https://doi.org/10.1021/jm800527x
Autor:
Charles Alois Dvorak, Francisco Javier Lopez-Tapia, Xiaojun Huang, Brad Loe, Debra A. Cockayne, William L. Fitch, Scott Broadbent, Berger Jacob, Christine E. Brotherton-Pleiss, Keith A. M. Walker, Rebecca Suttmann, David L. Bourdet, Lee Edwin Lowrie, Shelley K. Gleason, Dov Nitzan, Paul J. Wagner, Jiang Zhu, Zhao Shu-Hai, Fernando Padilla, André Alker, Joanie Caroon, Deborah Phippard, Alam Jahangir, Pankaj D. Rege
Publikováno v:
Journal of medicinal chemistry. 58(21)
Identification of singleton P2X7 inhibitor 1 from HTS gave a pharmacophore that eventually turned into potential clinical candidates 17 and 19. During development, a number of issues were successfully addressed, such as metabolic stability, plasma st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e880f027ef8eadeaef6f8cc77b4f99c
https://pubmed.ncbi.nlm.nih.gov/26460788
https://pubmed.ncbi.nlm.nih.gov/26460788
Autor:
André deRosier, David G. Loughhead, David Mark Rotstein, Shelley K. Gleason, Eun Kyung Lee, Fernando Padilla, Lina Setti, Dick Cournoyer, Remy Lemoine, Cheng-I. Mau, Paul Weller, Andreas Jekle, Jutta Wanner, Pamela Berry, Chris Richard Melville, Marianna Dioszegi, Ann C. Petersen, Surya Sankuratri, Jason Manka, Changhua Ji, Lin Xiao-Fa, Lijing Chen, Gabrielle Heilek, Lubov Filonova
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(10)
Starting with a high-throughput screening lead, a novel series of CCR5 antagonists was developed utilizing an information-based approach. Improvement of pharmacokinetic properties for the series was pursued by SAR exploration of the lead template. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757bbb465169e0977e2a95f17e17d1e6
https://pubmed.ncbi.nlm.nih.gov/20417098
https://pubmed.ncbi.nlm.nih.gov/20417098
Autor:
Anthony W. Thompson, Shelley K. Gleason, David S. Carter, Michael Patrick Dillon, Yansheng Zhai, Anthony P.D.W. Ford, Joel R Gever, Amy Geraldine Moore, Christine E. Brotherton-Pleiss, Clara Jeou Jen Lin, Marzia Villa
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(3)
Despite the extensive literature describing the role of the ATP-gated P2X 3 receptors in a variety of physiological processes the potential of antagonists as therapeutic agents has been limited by the lack of drug-like selective molecules. In this pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466f55626358f5c2c249a164fd47abc5
https://pubmed.ncbi.nlm.nih.gov/20045645
https://pubmed.ncbi.nlm.nih.gov/20045645