Výsledky vyhledávání - "Shelley K. Cockrell"

Residues of the UL25 Protein of Herpes Simplex Virus That Are Required for Its Stable Interaction with Capsids

Autor: Fred L. Homa, Katerina Toropova, James F. Conway, Jamie B. Huffman, Shelley K. Cockrell

Publikováno v: Journal of Virology. 85:4875-4887

The herpes simplex virus 1 (HSV-1) UL25 gene product is a minor capsid component that is required for encapsidation, but not cleavage, of replicated viral DNA. UL25 is located on the capsid surface in a proposed heterodimer with UL17, where five copi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fe4489b4e8da7c0d053ef1a34aa610
https://doi.org/10.1128/jvi.00242-11

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Polarized DNA Ejection from the Herpesvirus Capsid

Autor: William W. Newcomb, Jay C. Brown, Shelley K. Cockrell, Fred L. Homa

Publikováno v: Journal of Molecular Biology. 392:885-894

Ejection of DNA from the capsid is an early step in infection by all herpesviruses. Ejection or DNA uncoating occurs after a parental capsid has entered the host cell cytoplasm, migrated to the nucleus, and bound to a nuclear pore. DNA exits the caps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c2a8097245fec50021cbe4eba51876
https://doi.org/10.1016/j.jmb.2009.07.052

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Reducing the Risk of Adeno-Associated Virus (AAV) Vector Mobilization with AAV Type 5 Vectors

Autor: R. Jude Samulski, Shelley K. Cockrell, Steven J. Gray, F. Curtis Hewitt, Michael L. Washburn, Chengwen Li

Publikováno v: Journal of Virology. 83:3919-3929

Current adeno-associated virus (AAV) gene therapy vectors package a transgene flanked by the terminal repeats (TRs) of AAV type 2 (AAV2). Although these vectors are replication deficient, wild-type (wt) AAV2 prevalent in the human population could le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79282f05f643398ba8ee160d06981bd8
https://doi.org/10.1128/jvi.02466-08

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Whole genome sequencing of a single viral species from a highly heterogeneous sample

Autor: Paul G. Cantalupo, Martial Carbonnaux, David A. Weitz, Hee-Sun Han, Shelley K. Cockrell, Assaf Rotem, James M. Pipas

Metagenomic studies suggest that only a small fraction of the viruses that exist in nature have been identified and studied. Characterization of unknown viral genomes is hindered by the many genomes populating any virus sample. A new method is report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd88a1c45cfb5b0f2cc79f53979d868
https://europepmc.org/articles/PMC4715630/

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Isolation and Analysis of Rare Norovirus Recombinants from Coinfected Mice Using Drop-Based Microfluidics

Autor: Connie B. Chang, Eugene I. Shakhnovich, Jeffrey S. Lin, Assaf Rotem, James M. Pipas, Thomas Mehoke, Ye Tao, Yu Long Han, Abimbola O. Kolawole, Adrian W.R. Serohijos, Huidan Zhang, Nicholas S. Giacobbi, David A. Weitz, Shelley K. Cockrell, Christiane E. Wobus, Andrew B. Feldman

Publikováno v: Journal of virology. 89(15)

Human noroviruses (HuNoVs) are positive-sense RNA viruses that can cause severe, highly infectious gastroenteritis. HuNoV outbreaks are frequently associated with recombination between circulating strains. Strain genotyping and phylogenetic analyses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7be696eb846976e0dd350268b29e24
https://pubmed.ncbi.nlm.nih.gov/25972549

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Labeling and localization of the herpes simplex virus capsid protein UL25 and its interaction with the two triplexes closest to the penton

Autor: James F. Conway, Fred L. Homa, Anna Maria Copeland, Jay C. Brown, William W. Newcomb, Shelley K. Cockrell

Publikováno v: Journal of molecular biology. 397(2)

The herpes simplex virus type 1 UL25 protein is one of seven viral proteins that are required for DNA cleavage and packaging. Together with UL17, UL25 forms part of an elongated molecule referred to as the C-capsid-specific component (CCSC). Five cop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a912e639761179d0620bf9cfb1c5b413
https://pubmed.ncbi.nlm.nih.gov/20109467

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Role of the UL25 protein in herpes simplex virus DNA encapsidation

Autor: Angela Erazo, Minerva E. Sanchez, Shelley K. Cockrell, Fred L. Homa

Publikováno v: Journal of virology. 83(1)

The herpes simplex virus protein UL25 attaches to the external vertices of herpes simplex virus type 1 capsids and is required for the stable packaging of viral DNA. To define regions of the protein important for viral replication and capsid attachme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df42fe0ee3bfa39973e0a15fe62f7650
https://pubmed.ncbi.nlm.nih.gov/18945788

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