Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Shelley Halpain"'
INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury
Autor:
Barbara Calabrese, Steven L. Jones, Yoko Shiraishi-Yamaguchi, Michael Lingelbach, Uri Manor, Tatyana M. Svitkina, Henry N. Higgs, Andy Y. Shih, Shelley Halpain
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Post injury cytoskeletal modifications in neurons are not fully understood. Here the authors describe a pro-survival actin cytoskeletal reorganization in neurons triggered during a model of ischemic stroke.
Externí odkaz:
https://doaj.org/article/e90bdbb4354e4126b7538ddf3eccdbce
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
Neuron navigators (Navigators) are cytoskeletal-associated proteins important for neuron migration, neurite growth, and axon guidance, but they also function more widely in other tissues. Recent studies have revealed novel cellular functions of Navig
Externí odkaz:
https://doaj.org/article/daddae75737348a495850874794459d3
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Dendritic spines are small, bulbous protrusions along the dendrites of neurons and are sites of excitatory postsynaptic activity. The morphology of spines has been implicated in their function in synaptic plasticity and their shapes have been well-ch
Externí odkaz:
https://doaj.org/article/ec8fb9df82d64021b6279d6905b2e6b9
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94787 (2014)
A current model posits that cofilin-dependent actin severing negatively impacts dendritic spine volume. Studies suggested that increased cofilin activity underlies activity-dependent spine shrinkage, and that reduced cofilin activity induces activity
Externí odkaz:
https://doaj.org/article/787667ed60d748a7b8ab82c8825b337c
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102978 (2014)
General anesthetics produce a reversible coma-like state through modulation of excitatory and inhibitory synaptic transmission. Recent evidence suggests that anesthetic exposure can also lead to sustained cognitive dysfunction. However, the subcellul
Externí odkaz:
https://doaj.org/article/35a28ef178f2499885c2c539dc5c303e
Autor:
Regina M. Powers, Ray Daza, Alanna E. Koehler, Julien Courchet, Barbara Calabrese, Robert F. Hevner, Shelley Halpain
Publikováno v:
Molecular Biology of the Cell
Molecular Biology of the Cell, 2022, 33 (7), pp.ar64. ⟨10.1091/mbc.E21-12-0623⟩
Molecular Biology of the Cell, 2022, 33 (7), pp.ar64. ⟨10.1091/mbc.E21-12-0623⟩
Neuron Navigator 1 (Nav1) is a cytoskeleton-associated protein expressed during brain development that is necessary for proper neuritogenesis, but the underlying mechanisms are poorly understood. Here we show that Nav1 is present in elongating axon t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f208d1b8a16d5c583da7ed03b8223f
https://hal.science/hal-03746491
https://hal.science/hal-03746491
INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury
Autor:
Tatyana Svitkina, Uri Manor, Henry N. Higgs, Jones S, Lingelbach Mj, Barbara Calabrese, Shelley Halpain, Andy Y. Shih, Yamaguchi-Shiraishi Y
During early stages of ischemic brain injury, glutamate receptor hyperactivation mediates neuronal death via osmotic cell swelling. Here we show that ischemia and excess NMDA receptor activation – conditions that trigger neuronal swelling -- cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97ac480ee036f10cd40a0907f75dc5e9
https://doi.org/10.1101/2021.10.01.462790
https://doi.org/10.1101/2021.10.01.462790
Autor:
Barbara Calabrese, Shelley Halpain, Danielle L. Schmitt, Padmini Rangamani, Donya Ohadi, Jin Zhang
Publikováno v:
Biophysical Journal
Biophysical journal, vol 117, iss 10
Biophysical journal, vol 117, iss 10
Dendritic spines are the primary excitatory postsynaptic sites that act as subcompartments of signaling. Ca2+is often the first and most rapid signal in spines. Downstream of calcium, the cAMP/PKA pathway plays a critical role in the regulation of sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7e8c9c7282d6d07909669468aa3ec3
http://europepmc.org/articles/PMC7031750
http://europepmc.org/articles/PMC7031750
Publikováno v:
Journal of Visualized Experiments.
Neurons differentiated in two-dimensional culture from human pluripotent stem-cell-derived neural progenitor cells (NPCs) represent a powerful model system to explore disease mechanisms and carry out high content screening (HCS) to interrogate compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2f7475a340d2f07d19f7270e579199
https://doi.org/10.3791/59305
https://doi.org/10.3791/59305
Publikováno v:
Biophysical Journal. 120:47a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98002692e9446bf19d209b9c5e52bae7
https://doi.org/10.1016/j.bpj.2020.11.525
https://doi.org/10.1016/j.bpj.2020.11.525