Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Shelley Barnhart"'
Autor:
Valerie Z. Wall, Shelley Barnhart, Farah Kramer, Jenny E. Kanter, Anuradha Vivekanandan-Giri, Subramaniam Pennathur, Chiara Bolego, Jessica M. Ellis, Miguel A. Gijón, Michael J. Wolfgang, Karin E. Bornfeldt
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1174-1185 (2017)
Acyl-CoA thioesterase 7 (ACOT7) is an intracellular enzyme that converts acyl-CoAs to FFAs. ACOT7 is induced by lipopolysaccharide (LPS); thus, we investigated downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings
Externí odkaz:
https://doaj.org/article/83f7d024471b48379c8e62abb1b69a7f
Autor:
Tomohiro Nishizawa, Jenny E. Kanter, Farah Kramer, Shelley Barnhart, Xia Shen, Anuradha Vivekanandan-Giri, Valerie Z. Wall, Jason Kowitz, Sridevi Devaraj, Kevin D. O’Brien, Subramaniam Pennathur, Jingjing Tang, Robert S. Miyaoka, Elaine W. Raines, Karin E. Bornfeldt
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 356-365 (2014)
Summary: Inflammatory activation of myeloid cells is accompanied by increased glycolysis, which is required for the surge in cytokine production. Although in vitro studies suggest that increased macrophage glucose metabolism is sufficient for cytokin
Externí odkaz:
https://doaj.org/article/32b0ea688622451eb44b45bbeb1adb0e
Autor:
Sara N Vallerie, Farah Kramer, Shelley Barnhart, Jenny E Kanter, Richard M Breyer, Katrin I Andreasson, Karin E Bornfeldt
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158316 (2016)
Type 1 diabetes mellitus (T1DM) is associated with cardiovascular complications induced by atherosclerosis. Prostaglandin E2 (PGE2) is often raised in states of inflammation, including diabetes, and regulates inflammatory processes. In myeloid cells,
Externí odkaz:
https://doaj.org/article/8b40cda0075c41e995fa4c018d2e4c8b
Autor:
Deidre L. Golej, Bardia Askari, Farah Kramer, Shelley Barnhart, Anuradha Vivekanandan-Giri, Subramaniam Pennathur, Karin E. Bornfeldt
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 4, Pp 782-793 (2011)
Long-chain acyl-CoA synthetases (ACSLs) catalyze the thioesterification of long-chain FAs into their acyl-CoA derivatives. Purified ACSL4 is an arachidonic acid (20:4)-preferring ACSL isoform, and ACSL4 is therefore a probable regulator of lipid medi
Externí odkaz:
https://doaj.org/article/29882182520c4a86a72b758a8fca3cb0
Autor:
Florian Willecke, Chujun Yuan, Kazuhiro Oka, Lawrence Chan, Yunying Hu, Shelley Barnhart, Karin E Bornfeldt, Ira J Goldberg, Edward A Fisher
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128996 (2015)
We tested whether a high fat diet (HFD) containing the inflammatory dietary fatty acid palmitate or insulin deficient diabetes altered the remodeling of atherosclerotic plaques in LDL receptor knockout (Ldlr-/-) mice. Cholesterol reduction was achiev
Externí odkaz:
https://doaj.org/article/01c17747e69b490eb9c42001f68854a7
Autor:
Yunosuke Matsuura, Masami Shimizu-Albergine, Shelley Barnhart, Farah Kramer, Cheng-Chieh Hsu, Vishal Kothari, Jingjing Tang, Sina A. Gharib, Jenny E. Kanter, E. Dale Abel, Rong Tian, Baohai Shao, Karin E. Bornfeldt
Publikováno v:
Circ Res
This manuscript was sent to Joyce Bischoff, Guest Editor, for review by expert referees, editorial decision, and final disposition. Final decisions were approved by Jane Leopold, Guest Editor-in-Chief.
Autor:
Vishal Kothari, Baohai Shao, Yi He, Farah Kramer, Shelley Barnhart, Jenny E Kanter, Alan Chait, Ira J Goldberg, Edward A Fisher, Tomas Vaisar, Karin E Bornfeldt
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Despite the benefits of LDL-cholesterol-reducing medications, patients with type 1 diabetes (T1D) continue to have an increased risk of incident CVD. Preclinical and clinical observations indicate that triglyceride-rich lipoproteins (TRLs) and their
Autor:
Shelley Barnhart, Noemie Clouet-Foraison, Ira J. Goldberg, Karin E. Bornfeldt, Jenny E. Kanter, Vishal Kothari, Carissa Thornock, Adam E. Mullick, Jay W. Heinecke, Tomas Vaisar, Debapriya Basu, Farah Kramer, Masami Shimizu-Albergine, Robert A. Hegele
Publikováno v:
J Clin Invest
Loss-of-function mutations in the transcription factor CREB3L3 (CREBH) associate with severe hypertriglyceridemia in humans. CREBH is believed to lower plasma triglycerides by augmenting the activity of lipoprotein lipase (LPL). However, by using a m
Autor:
Tomas Vaisar, John E. Hokanson, Daniel Mar, Jenny E. Kanter, Karol Bomsztyk, Shelley Barnhart, Karin E. Bornfeldt, Jay W. Heinecke, Mark J. Graham, Gregory L. Kinney, Masami Shimizu-Albergine, Janet K. Snell-Bergeon, Rebecca A. Haeusler, Baohai Shao, Farah Kramer, Rosanne M. Crooke, Clarence R. Manuel
Publikováno v:
Journal of Clinical Investigation. 129:4165-4179
Type 1 diabetes mellitus (T1DM) increases the risk of atherosclerotic cardiovascular disease (CVD) in humans by poorly understood mechanisms. Using mouse models of T1DM-accelerated atherosclerosis, we found that relative insulin deficiency rather tha
Autor:
Vishal Kothari, Stephan D. Bouman, Jeffrey M. Duggan, Masami Shimizu-Albergine, Grith Skytte Olsen, Alan Chait, Jenny E. Kanter, Karin E. Bornfeldt, Farah Kramer, Bo Falck Hansen, Shelley Barnhart, Jessica A. Hamerman
Publikováno v:
Diabetes. 67:946-959
Cardiovascular disease caused by atherosclerosis is the leading cause of mortality associated with type 2 diabetes and metabolic syndrome. Insulin therapy is often needed to improve glycemic control, but it does not clearly prevent atherosclerosis. U