Quantifiable blood TCR repertoire components associate with immune aging

Autor: Jing Hu, Mingyao Pan, Brett Reid, Shelley Tworoger, Bo Li

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract T cell senescence alters the homeostasis of distinct T cell populations and results in decayed adaptive immune protection in older individuals, but a link between aging and dynamic T cell clone changes has not been made. Here, using a newly

Externí odkaz: https://doaj.org/article/760a7d084130442ab7003b4c51bfd939

Abstract 3024: Development of a plasma metabolomics prediction model for early detection of ovarian cancer using prospectively collected blood samples in two independent cohorts

Autor: Oana A. Zeleznik, Julian Avila-Pacheco, Daniel W. Cramer, Britton Trabert, Clary B. Clish, Shelley Tworoger, Kathryn L. Terry, Naoko Sasamoto

Publikováno v: Cancer Research. 83:3024-3024

Background: Ovarian cancer has poor survival due to more than 60% of patients being diagnosed at advanced stage. Therefore, discovery of novel, non-invasive early detection biomarkers has high potential to improve outcomes. Here, using prospectively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::feb9cbf69e8eb23135d7a9b2706ee873
https://doi.org/10.1158/1538-7445.am2023-3024

Lymphocyte infiltration in histologic subtypes of epithelial ovarian carcinoma and its effect on survival (229)

Autor: Sumit Mehta, Subir Biswas, Gunjan Mandal, Alexandra Martin, Naoko Sasamoto, Kathryn Terry, Douglas Marchion, Mary Townsend, Shelley Tworoger, Robert Wenham, Jose Conejo-Garcia

Publikováno v: Gynecologic Oncology. 166:S127

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfcb7eabd3321ebe99b44e02672c5694
https://doi.org/10.1016/s0090-8258(22)01454-8

The role of rurality in cancer treatment disruptions among patients with cancer diagnosed with SARS-CoV-2: An analysis of the ASCO Survey on COVID-19 in Oncology Registry

Autor: Jessica Yasmine Islam, Kea Turner, Cassandra Hathaway, Emma Hume, Julie E. Hallanger-Johnson, Shelley Tworoger, Marlene Camacho-Rivera

Publikováno v: Journal of Clinical Oncology. 40:6554-6554

6554 Background: U.S. rural cancer patients experience multifactorial barriers to cancer treatment; however, little is known about the impact of the pandemic on cancer treatment delays or discontinuations (TDD) in the rural context. Our objective was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acf00efd06e6d8791a6a164b656053df
https://doi.org/10.1200/jco.2022.40.16_suppl.6554

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

Autor: Andrea D Coviello, Robin Haring, Melissa Wellons, Dhananjay Vaidya, Terho Lehtimäki, Sarah Keildson, Kathryn L Lunetta, Chunyan He, Myriam Fornage, Vasiliki Lagou, Massimo Mangino, N Charlotte Onland-Moret, Brian Chen, Joel Eriksson, Melissa Garcia, Yong Mei Liu, Annemarie Koster, Kurt Lohman, Leo-Pekka Lyytikäinen, Ann-Kristin Petersen, Jennifer Prescott, Lisette Stolk, Liesbeth Vandenput, Andrew R Wood, Wei Vivian Zhuang, Aimo Ruokonen, Anna-Liisa Hartikainen, Anneli Pouta, Stefania Bandinelli, Reiner Biffar, Georg Brabant, David G Cox, Yuhui Chen, Steven Cummings, Luigi Ferrucci, Marc J Gunter, Susan E Hankinson, Hannu Martikainen, Albert Hofman, Georg Homuth, Thomas Illig, John-Olov Jansson, Andrew D Johnson, David Karasik, Magnus Karlsson, Johannes Kettunen, Douglas P Kiel, Peter Kraft, Jingmin Liu, Östen Ljunggren, Mattias Lorentzon, Marcello Maggio, Marcello R P Markus, Dan Mellström, Iva Miljkovic, Daniel Mirel, Sarah Nelson, Laure Morin Papunen, Petra H M Peeters, Inga Prokopenko, Leslie Raffel, Martin Reincke, Alex P Reiner, Kathryn Rexrode, Fernando Rivadeneira, Stephen M Schwartz, David Siscovick, Nicole Soranzo, Doris Stöckl, Shelley Tworoger, André G Uitterlinden, Carla H van Gils, Ramachandran S Vasan, H-Erich Wichmann, Guangju Zhai, Shalender Bhasin, Martin Bidlingmaier, Stephen J Chanock, Immaculata De Vivo, Tamara B Harris, David J Hunter, Mika Kähönen, Simin Liu, Pamela Ouyang, Tim D Spector, Yvonne T van der Schouw, Jorma Viikari, Henri Wallaschofski, Mark I McCarthy, Timothy M Frayling, Anna Murray, Steve Franks, Marjo-Riitta Järvelin, Frank H de Jong, Olli Raitakari, Alexander Teumer, Claes Ohlsson, Joanne M Murabito, John R B Perry

Publikováno v: PLoS Genetics, Vol 8, Iss 7, p e1002805 (2012)

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D

Externí odkaz: https://doaj.org/article/4a9def3535b34414a48d70d8f4aa1e06