Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shelise Brooks"'
Autor:
Nicolas Altemose, Glennis A. Logsdon, Andrey V. Bzikadze, Pragya Sidhwani, Sasha A. Langley, Gina V. Caldas, Savannah J. Hoyt, Lev Uralsky, Fedor D. Ryabov, Colin J. Shew, Michael E. G. Sauria, Matthew Borchers, Ariel Gershman, Alla Mikheenko, Valery A. Shepelev, Tatiana Dvorkina, Olga Kunyavskaya, Mitchell R. Vollger, Arang Rhie, Ann M. McCartney, Mobin Asri, Ryan Lorig-Roach, Kishwar Shafin, Julian K. Lucas, Sergey Aganezov, Daniel Olson, Leonardo Gomes de Lima, Tamara Potapova, Gabrielle A. Hartley, Marina Haukness, Peter Kerpedjiev, Fedor Gusev, Kristof Tigyi, Shelise Brooks, Alice Young, Sergey Nurk, Sergey Koren, Sofie R. Salama, Benedict Paten, Evgeny I. Rogaev, Aaron Streets, Gary H. Karpen, Abby F. Dernburg, Beth A. Sullivan, Aaron F. Straight, Travis J. Wheeler, Jennifer L. Gerton, Evan E. Eichler, Adam M. Phillippy, Winston Timp, Megan Y. Dennis, Rachel J. O’Neill, Justin M. Zook, Michael C. Schatz, Pavel A. Pevzner, Mark Diekhans, Charles H. Langley, Ivan A. Alexandrov, Karen H. Miga
Publikováno v:
Science
INTRODUCTION: To faithfully distribute genetic material to daughter cells during cell division, spindle fibers must couple to DNA by means of a structure called the kinetochore, which assembles at each chromosome’s centromere. Human centromeres are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6fdde181caa00d2a2585b6b9de02d9
https://doi.org/10.1101/2021.07.12.452052
https://doi.org/10.1101/2021.07.12.452052
Autor:
Sirintorn Stantripop, Sean Black, Ricardo D’Oliveira Albanus, S. L. Ho, John P. Didion, Beatrice B. Barnabas, Francis S. Collins, Brian P. Schmidt, Peter Orchard, Quino Maduro, Casandra Montemayor, Christina Sison, Karen L. Mohlke, Hannah J Perrin, K. Alaine Broadaway, Alice C. Young, Juyun Kim, Morgan Park, Laura J. Scott, Swarooparani Vadlamudi, Erin G. Schuetz, Karen Schandler, Narisu Narisu, James W. Thomas, Richelle Legaspi, Shelise Brooks, Gerard G. Bouffard, Joel Han, Federico Innocenti, Nancy Riebow, Vivek Rai, Lyudmila Dekhtyar, James C. Mullikin, Stephen C. J. Parker, Michael R. Erdos, Holly Coleman, Tingfen Yan, Catherine A. Masiello, Lori L. Bonnycastle, Jacqueline R. Idol, Amarjit S. Chaudhry, Jennifer C. McDowell, Kevin W Currin, Meghana Vemulapalli, Pamela J. Thomas, Amy S. Etheridge
Publikováno v:
Am J Hum Genet
Identifying the molecular mechanisms by which genome-wide association study (GWAS) loci influence traits remains challenging. Chromatin accessibility quantitative trait loci (caQTLs) help identify GWAS loci that may alter GWAS traits by modulating ch
Autor:
David Porubsky, Gulhan Kaya, Ruta Sahasrabudhe, James C. Mullikin, Joel Armstrong, Amy B. Wilfert, Jonathan Wood, Edmund Howe, Ariel Gershman, Amalia Dutra, Jon Matthew Belton, Alexander M. Chang, Karen H. Miga, Valerie A. Schneider, Adam M. Phillippy, Alice Young, Andrey Bzikadze, Tamara A. Potapova, Rosa Ana Risques, Anthony D. Schmitt, Tina A. Graves Lindsay, Gerard G. Bouffard, Nancy F. Hansen, Benedict Paten, Josh Quick, Ira M. Hall, Glennis A. Logsdon, Sergey Koren, Kristof Tigyi, Nadine Holmes, Daniela C. Soto, Beth A. Sullivan, Jeanne Fredrickson, Robert S. Fulton, Siddarth Selvaraj, Milinn Kremitzki, Winston Timp, Nicholas J. Loman, Arang Rhie, Evan E. Eichler, Megan Y. Dennis, Kerstin Howe, Jennifer L. Gerton, Urvashi Surti, Valerie Maduro, Christopher Markovic, Pavel A. Pevzner, Françoise Thibaud-Nissen, William Chow, Shelise Brooks, Evgenia Pak, Matthew Loose, Mitchell R. Vollger
Publikováno v:
Nature, vol 585, iss 7823
Nature
Nature
After two decades of improvements, the current human reference genome (GRCh38) is the most accurate and complete vertebrate genome ever produced. However, no single chromosome has been finished end to end, and hundreds of unresolved gaps persist1,2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b763e6dc69f68a2c414f6d2d8a9e4a86
https://escholarship.org/uc/item/88w7j3n7
https://escholarship.org/uc/item/88w7j3n7
Autor:
Carsten G. Bönnemann, Francis J. McMahon, Quino Maduro, Alan T. Remaley, Brian P. Brooks, Sirintorn Stantripop, Jennifer C. McDowell, Kendall L. Umstead, Gerard G. Bouffard, Erin Turbitt, Catherine A. Masiello, Karen Schandler, Jeffrey Baron, Jennifer J. Johnston, Beatrice B. Barnabas, Richelle Legaspi, James W. Thomas, Holly Coleman, Eileen Pelayo, Barbara B. Biesecker, D. Nadine Dogbe, Ilias Alevizos, Joel Moss, W. Marston Linehan, Helen C. Su, Casandra Montemayor, Brian Schmidt, Alice C. Young, Morgan Park, Meghana Vemulapalli, Richard M. Siegel, Pamela J. Thomas, Chanthra Scharer, Youn Hee Jee, Deborah Nielsen, Carlos A. Zarate, Christina Sison, Leslie G. Biesecker, Alexis R Heidlebaugh, Sandra Donkervoort, Nancy Riebow, Shelise Brooks, James C. Mullikin, Teri A. Manolio, Julie C. Sapp, Xiaobin Guan, Ane Miren Sagardia, S. L. Ho, Kate Driscoll, Joel Han, Lyudmila Dekhtyar
© 2018 While consensus regarding the return of secondary genomic findings in the clinical setting has been reached, debate about such findings in the research setting remains. We developed a hybrid, research-clinical translational genomics process f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8f30234ebb7d1b8ff21c42057bf2c8
https://europepmc.org/articles/PMC6128311/
https://europepmc.org/articles/PMC6128311/
Autor:
John R. Mascola, Quino Maduro, Christina Sison, Jenny McDowell, Chaim A. Schramm, Lawrence Shapiro, Brian P. Schmidt, Betty Benjamin, Karen Schandler, Cathy Masiello, Richelle Legaspi, Pam Thomas, James Thomas, Zizhang Sheng, Nisc Comparative Sequencing Program, Raymond Arthur Smith, Jessica Rosarda, Xiaobin Guan, Shelise Brooks, James C. Mullikin, Mila Dekhtyar, Nancy Riebow, Joel Han, Gerry Bouffard, Holly Coleman, Casandra Montemayor, Meg Vemulapalli, Mal Stantripop, Peter D. Kwong, Rui Kong, Alice Young, Morgan Park, Shi ling Ho
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology, Vol 8 (2017)
Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of surrounding
Autor:
Sean Lovett, Stephen C. J. Parker, Holly Coleman, Narisu Narisu, D. Leland Taylor, Morgan Park, Len A. Pennacchio, Taccara Johnson, Jenny McDowell, Baishali Maskeri, Meg Vemulapalli, Axel Visel, April Hargrove, Jennifer A. Akiyama, James Thomas, Michael R. Erdos, Cathy Masiello, Michael D. Gregory, Brian L. Schmidt, Peter S. Chines, Michael L. Stitzel, Quino Maduro, Betty Benjamin, Shi-ling Ho, Robert W. Blakesley, Xiaobin Guan, Francis S. Collins, Karen Schandler, Mal Stantripop, Casandra Montemayor, Richelle Legaspi, Jesse Becker, Kelly Lammerts van Bueren, Alice Young, Nancy Riebow, James C. Mullikin, Christina Sison, Jyoti Gupta, Nisc Comparative Sequencing Program, Mila Dekhtyar, Joel Han, Jose M. Orozco, Brian L. Black, Pam Thomas, Shelise Brooks, Gerry Bouffard
Publikováno v:
Proceedings of the National Academy of Sciences. 110:17921-17926
Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcripto
Autor:
Steven A. Rosenberg, Quino Maduro, Sean Lovett, Hannah Carter, Laura Elnitski, Sean Davis, Betty Benjamin, Nicholas K. Hayward, J. Lin, Michael D. Gregory, Chava Kimchi-Sarfaty, James Thomas, Michael A. Davies, Michael L. Stitzel, Rachel Karchin, Alice Young, Pam Thomas, Xiaobin Guan, Casandra Montemayor, Jesse Becker, Jamie K. Teer, Nancy Riebow, Shelise Brooks, Elliott H. Margulies, Gerry Bouffard, Holly Coleman, Jyoti Gupta, Brian L. Schmidt, Morgan Park, James C. Mullikin, Karen Schandler, Francis S. Collins, Cathy Masiello, Xiaomu Wei, Baishali Maskeri, Sujata Jha, William A. Robinson, Richelle Legaspi, Yardena Samuels, Shi-ling Ho, Steven E. Robinson, Christina Sison, Ken Dutton-Regester, Meg Vemulapalli, Todd D. Prickett, Jenny McDowell, Valer Gotea, Taccara Johnson, Nobuko H. Katagiri, Robert W. Blakesley, Umesh Bhanot, Guo Chen, Vijaya L. Simhadri, Stephen C. J. Parker, Jared J. Gartner, Mal Stantripop, Mila Dekhtyar, Jeffrey E. Gershenwald, Joel Han, Mario A. Morken, Giovanni Parmigiani, April Hargrove, Anton A. Komar
Publikováno v:
Proceedings of the National Academy of Sciences. 110:13481-13486
Synonymous mutations, which do not alter the protein sequence, have been shown to affect protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12(10):683–691]. However, synonymous mutations are rarely investigated in the cancer genomics
Autor:
John R. Mascola, Yongping Yang, Melissa Simek, S. Munir Alam, Christina Sison, Sean Lovett, April Hargrove, Julie Blinn, Robert W. Blakesley, Cathy Masiello, Nancy Riebow, Lawrence Shapiro, James C. Mullikin, Gabriel Lu, Jeff Skinner, Dennis R. Burton, Krisha McKee, Pam Thomas, Barton F. Haynes, Joshua Eudailey, Shi-ling Ho, Betty Benjamin, Nisc Comparative Sequencing Program, Holly Coleman, Jiang Zhu, Quino Maduro, Zhenhai Zhang, Mila Dekhtyar, Gilad Ofek, Karen Schandler, Joel Han, Richelle Legaspi, Jenny McDowell, Taccara Johnson, Mal Stantripop, Jesse Becker, Krissey E. Lloyd, James Thomas, Shelise Brooks, Gerry Bouffard, Alice Young, Baoshan Zhang, Meg Vemulapalli, Brian L. Schmidt, Marie Pancera, Peter D. Kwong, Mark K. Louder, Baishali Maskeri, Morgan Park, Robert Parks, Jyoti Gupta, Michael D. Gregory, Wayne C. Koff, Xiaobin Guan, Casandra Montemayor
Publikováno v:
Proceedings of the National Academy of Sciences. 110:6470-6475
Next-generation sequencing of antibody transcripts from HIV-1–infected individuals with broadly neutralizing antibodies could provide an efficient means for identifying somatic variants and characterizing their lineages. Here, we used 454 pyroseque
Autor:
Joy Y. Yang, Adrian M. Zelazny, Shelise Brooks, Evan S. Snitkin, Robert R. Blakesley, Julia A. Segre, Jennifer A. Meyer
Publikováno v:
Journal of Clinical Microbiology. 51:752-758
With increasing rates of antibiotic resistance, bacterial infections have become more difficult to treat, elevating the importance of surveillance and prevention. Effective surveillance relies on the availability of rapid, cost-effective, and informa
Autor:
Chung-Yi Wu, Michael Gregory, Brian P. Schmidt, Peter D. Kwong, Reda Rawi, Yongping Yang, Cathy Masiello, Chang-Chun D Lee, James C. Mullikin, Shi-ling Ho, Anqi Zheng, John R. Mascola, Karen Schandler, Richelle Legaspi, Holly Coleman, Chen-Hsiang Shen, Mila Dekhtyar, Catherine Stevenson, Vidya S. Shivatare, Joel Han, Rui Kong, Xiaobin Guan, Casandra Montemayor, Gwo-Yu Chuang, Dennis R. Burton, Krisha McKee, Jenny McDowell, Eric Waltari, Pam Thomas, Justin Taft, Chi-Huey Wong, Mal Stantripop, Sijy O'Dell, Xueling Wu, Morgan Park, Shelise Brooks, Meg Vemulapalli, Gerry Bouffard, Lawrence Shapiro, Mark K. Louder, Robert W. Blakesley, Baishali Maskeri, Victoria R. Polonis, Ivelin S. Georgiev, Sachin S. Shivatare, Yaroslav Tsybovsky, Baoshan Zhang, April Hargrove, Syna Gift, Tongqing Zhou, Betty Benjamin, Syed Shahzad-ul-Hussan, Alice Young, James W. Thomas, Carole A. Bewley, Jyoti Gupta, Guillaume Stewart-Jones, Quino Maduro, Nancy Riebow, Christina Sison, Robert T. Bailer, Ulrich Baxa
Publikováno v:
Immunity. 48:500-513.e6
Summary Virtually the entire surface of the HIV-1-envelope trimer is recognized by neutralizing antibodies, except for a highly glycosylated region at the center of the "silent face" on the gp120 subunit. From an HIV-1-infected donor, #74, we identif