Toxicity and Local Tolerance of a Novel Spike Protein RBD Vaccine Against SARS-CoV-2, Produced Using the C1 Thermothelomyces Heterothallica Protein Expression Platform

Autor: Yuval Ramot, Noam Kronfeld, Yakir Ophir, Nati Ezov, Sheli Friedman, Markku Saloheimo, Marika Vitikainen, Hanna Ben-Artzi, Avi Avigdor, Ronen Tchelet, Noelia Valbuena Crespo, Mark Emalfarb, Abraham Nyska

Publikováno v: Ramot, Y, Kronfeld, N, Ophir, Y, Ezov, N, Friedman, S, Saloheimo, M, Vitikainen, M, Ben-Artzi, H, Avigdor, A, Tchelet, R, Valbuena Crespo, N, Emalfarb, M & Nyska, A 2022, ' Toxicity and Local Tolerance of a Novel Spike Protein RBD Vaccine Against SARS-CoV-2, Produced Using the C1 Thermothelomyces Heterothallica Protein Expression Platform ', Toxicologic Pathology, vol. 50, no. 3, pp. 294-307 . https://doi.org/10.1177/01926233221090518

Coronavirus disease 2019 (COVID-19) has caused the ongoing COVID-19 pandemic and there is a growing demand for safe and effective vaccines. The thermophilic Thermothelomyces heterothallica filamentous fungal host, C1-cell, can be utilized as an expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f79b567e7cfca14a7dc07a5fcc0676
https://cris.vtt.fi/en/publications/7d21d8d0-a135-4ea9-8a15-c38154829a22

Sodium ions allosterically modulate the M2 muscarinic receptor

Autor: Merav Tauber, Yair Ben-Chaim, Sheli Friedman

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)

G protein coupled receptors (GPCRs) play a key role in the vast majority of cellular signal transduction processes. Previous experimental evidence has shown that sodium ion (Na+) allosterically modulate several class A GPCRs and theoretical studies s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d822c5158e4bb34c276fd60705c8403
http://europepmc.org/articles/PMC7341750

Molecular targets on mast cells and basophils for novel therapies

Autor: Ilkka T. Harvima, Marcus Maurer, Sheli Friedman, Ulrich Blank, Francesca Levi-Schaffer, Gunnar Nilsson, Bernhard F. Gibbs, Iva Polakovicova, Petr Dráber

Publikováno v: Journal of Allergy and Clinical Immunology. 134:530-544

Mast cells and basophils (MCs/Bs) play a crucial role in type I allergy, as well as in innate and adaptive immune responses. These cells mediate their actions through soluble mediators, some of which are targeted therapeutically by, for example, H1-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e863590d979ed2f0717fcff0295280
https://doi.org/10.1016/j.jaci.2014.03.007

Mast cells and eosinophils in allergy: Close friends or just neighbors

Autor: Roopesh Singh Gangwar, Mansour Seaf, Francesca Levi-Schaffer, Sheli Friedman

Publikováno v: European journal of pharmacology. 778

Mast cells are mostly known for their role in allergic diseases although in recent years it has become clear that they have a role in other diseases and in the body's defense against microbes. In most cases, but especially in allergy, eosinophils are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9385deb7698a3ae7aaa3bcdd66aa7df4
https://pubmed.ncbi.nlm.nih.gov/26526347

Chapter 4 Histamine Receptors and Inflammatory Cells

Autor: Madeleine Ennis, Francesca Levi-Schaffer, Sheli Friedman, Tomas Perecko, Antonín Lojek, Holger Stark, Francisca Sánchez-Jiménez, Liam O'Mahony, Ondřej Vašíček, Helena Migalovich-Sheikhet, S G Roopesh, José Luis Urdiales, Bernhard F. Gibbs, Karim Dib, Milan Ciz

Publikováno v: Histamine H4 Receptor: A Novel Drug Target in Immunoregulation and Inflammation ISBN: 9788376560540

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9f537baa8f8fdc2626b1e8f2711f59d
https://doi.org/10.2478/9788376560564.c4