Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Sheldon P. Rothenberg"'
Autor:
Jacob Selhub, Jeffrey M. Sequeira, Vincent Ramaekers, Thomas Opladen, Edward V. Quadros, Sheldon P. Rothenberg, Nenad Blau
Publikováno v:
New England Journal of Medicine. 352:1985-1991
In infantile-onset cerebral folate deficiency, 5-methyltetrahydrofolate (5MTHF) levels in the cerebrospinal fluid are low, but folate levels in the serum and erythrocytes are normal. We examined serum specimens from 28 children with cerebral folate d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543f6681977687f024b77e4df144c2e5
https://doi.org/10.1056/nejmoa043160
https://doi.org/10.1056/nejmoa043160
Autor:
Nancy A. Brada, David H. Alpers, Angel F. Remacha, Marilyn M. Gordon, René Santer, Edward V. Quadros, Montserrat Baiget, Sheldon P. Rothenberg, Isabel Badell, Elisabeth del Río
Publikováno v:
Human Mutation. 23:85-91
Congenital intrinsic factor (IF) deficiency is a disorder characterized by megaloblastic anemia due to the absence of gastric IF (GIF, GenBank NM_005142) and GIF antibodies, with probable autosomal recessive inheritance. Most of the reported patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e2a8fd255fe4eb11233e19d99aadbd
https://doi.org/10.1002/humu.10297
https://doi.org/10.1002/humu.10297
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 67:837-847
BACKGROUND Folic acid (FA) supplementation reduces neural tube defects (NTDs) by 70%. However, the cause of most NTDs cannot be attributed to folate deficiency, to mutations of genes that encode folate pathway enzymes, and folate receptors (FRs) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9a7ee643505d7e30b038d4d8287109
https://doi.org/10.1002/bdra.10088
https://doi.org/10.1002/bdra.10088
Publikováno v:
Gene. 291:149-158
The KB cell, a transformed human cell line, constitutively expresses a high level of the glycosylphosphatidylinositol (GPI) anchored folate receptor protein alpha (FR alpha) and thereby can grow in medium containing1 nM folate. When transferred from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d26d3370c21746d18e6ee9ac0be1c14
https://doi.org/10.1016/s0378-1119(02)00591-7
https://doi.org/10.1016/s0378-1119(02)00591-7
Autor:
Lars Örning, Sergey N. Fedosov, Sundrehagen Erling, Sheldon P. Rothenberg, Marius Andreas Ulleland, Ingar Eilertsen, Edward V. Quadros
Publikováno v:
Clinical Chemistry. 48:526-532
Background: Only cobalamin carried by transcobalamin (holo-transcobalamin) is available for cellular uptake and hence is physiologically relevant. However, no reliable or accurate methods for quantifying holo-transcobalamin are available. We report a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb0ebf3a76c9cceab1983bd2bcf3ccfa
https://doi.org/10.1093/clinchem/48.3.526
https://doi.org/10.1093/clinchem/48.3.526
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 277:G161-G166
This study was designed to identify the cellular component of the intestinal villus where transcobalamin II (TCII) is synthesized, because this protein provides an essential function in the intestinal absorption of vitamin B12(cobalamin, Cbl). When a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c2377c2d73a32824131dd56c0226ee
https://doi.org/10.1152/ajpgi.1999.277.1.g161
https://doi.org/10.1152/ajpgi.1999.277.1.g161
Autor:
Edward V. Quadros, Gary R. McLean, Hermann J. Ziltener, John W. Schrader, Sheldon P. Rothenberg, A. Charles Morgan
Publikováno v:
Blood. 89:235-242
The plasma protein transcobalamin II (TCII) binds and delivers cobalamin (Cbl; vitamin B12) to all cells, which internalize the TCII/Cbl complex by receptor-mediated endocytosis. Congenital deficiency of TCII results in intracellular Cbl deficiency,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06dde172a440293e21d50616495a6017
https://doi.org/10.1182/blood.v89.1.235
https://doi.org/10.1182/blood.v89.1.235
Publikováno v:
Biochemical and Biophysical Research Communications. 222:149-154
Cellular uptake of cobalamin (Cbl) is mediated by transcobalamin II (TCII), a Cbl binding protein in the plasma. The TCII-Cbl complex binds to a cell surface receptor and is internalized by endocytosis. We have generated monoclonal antibodies (mAbs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b130888f921986d8b40b954ead8d75e
https://doi.org/10.1006/bbrc.1996.0713
https://doi.org/10.1006/bbrc.1996.0713
Publikováno v:
Baillière's Clinical Haematology. 8:499-514
Summary Transcobalamin II is a plasma protein that binds vitamin B 12 (cobalamin) as it is absorbed in the terminal ileum and distributes it to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48be690269e12e12b1826c9eee4f2218
https://doi.org/10.1016/s0950-3536(05)80218-5
https://doi.org/10.1016/s0950-3536(05)80218-5
Publikováno v:
Blood. 85:2711-2719
Transcobalamin II (TCII) is a plasma protein that binds vitamin B12 (cobalamin; Cbl) and facilitates the cellular uptake of the vitamin by receptor-mediated endocytosis. In genetic disorders that are characterized by congenital deficiency of TCII, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7659dbf22ffcd73f79f0c924441e9c2c
https://doi.org/10.1182/blood.v85.10.2711.bloodjournal85102711
https://doi.org/10.1182/blood.v85.10.2711.bloodjournal85102711