Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Sheldon L, Morris"'
Autor:
Marcela Parra, Xia Liu, Steven C Derrick, Amy Yang, Alvaro Molina-Cruz, Carolina Barillas-Mury, Hong Zheng, Phuong Thao Pham, Martha Sedegah, Arnel Belmonte, Dianne D Litilit, Thomas A Waldmann, Sanjai Kumar, Sheldon L Morris, Liyanage P Perera
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141141 (2015)
Malaria remains a major global public health problem with an estimated 200 million cases detected in 2012. Although the most advanced candidate malaria vaccine (RTS,S) has shown promise in clinical trials, its modest efficacy and durability have crea
Externí odkaz:
https://doaj.org/article/59b81d0ef4ea4476999c181cab6bec95
Publikováno v:
BioTechniques, Vol 40, Iss 6, Pp 759-763 (2006)
A simple and efficient PCR method was developedfor generating dye- or radiolabeled single-stranded DNA targets or probes used for hybridization studies. The method involved the use of a pair of long primers with high annealing temperatures and a shor
Externí odkaz:
https://doaj.org/article/1b2292ad6617448987e349296a101e9e
Autor:
Marcela Parra, Xia Liu, Steven C Derrick, Amy Yang, Jinhua Tian, Kristopher Kolibab, Sanjai Kumar, Sheldon L Morris
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e66115 (2013)
Although the effectiveness of BCG vaccination in preventing adult pulmonary tuberculosis (TB) has been highly variable, epidemiologic studies have suggested that BCG provides other general health benefits to vaccinees including reducing the impact of
Externí odkaz:
https://doaj.org/article/c2479cd7bc034c8782ab0b4dfc69ac5d
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32959 (2012)
A new vaccination strategy is urgently needed for improved control of the global tuberculosis (TB) epidemic. Using a mouse aerosol Mycobacterium tuberculosis challenge model, we investigated the protective efficacy of a mmaA4 gene deletion mutant of
Externí odkaz:
https://doaj.org/article/6966100ffd8d40aab99de01377ea79e3
Autor:
Marcela Parra, Steven C Derrick, Amy Yang, Jinhua Tian, Kristopher Kolibab, Miranda Oakley, Liyanage P Perera, William R Jacobs, Sanjai Kumar, Sheldon L Morris
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28164 (2011)
BackgroundGiven the considerable geographic overlap in the endemic regions for malaria and tuberculosis, it is probable that co-infections with Mycobacterium tuberculosis and Plasmodium species are prevalent. Thus, it is quite likely that both malari
Externí odkaz:
https://doaj.org/article/df3c96438f09451bb3997b3c63abd179
Publikováno v:
Clinical and Vaccine Immunology. 23:638-647
Earlier studies aimed at defining protective immunity induced by Mycobacterium bovis BCG immunization have largely focused on the induction of antituberculosis CD4 + and CD8 + T cell responses. Here we describe a vaccine consisting of a BCGΔ mmaA4 d
Publikováno v:
Vaccine. 33:126-132
While formulating Mycobacterium bovis BCG in lipid-based adjuvants has been shown to increase the vaccine's protective immunity, the biological mechanisms responsible for the enhanced potency of lipid encapsulated BCG are unknown. To assess whether m
Autor:
Aditi Sengupta Banerjee, Bikash R. Sahu, Miranda S. Oakley, Phuong Thao Pham, Victoria Majam, Sheldon L. Morris, Leda Lotspeich-Cole, Yukiko Kozakai, Sanjai Kumar
Publikováno v:
European Journal of Immunology. 44:2680-2691
CD4(+) T-cell subtypes govern the synthesis of different Ab isotypes and other immune functions. The influence of CD4(+) T-cell differentiation programs on isotype switching and other aspects of host immunological networks during malaria infection ar
Autor:
Victoria Majam, Miranda S. Oakley, L. Aravind, Noel J. Gerald, Sanjai Kumar, Babita Mahajan, Phuong Thao Pham, Leda Lotspeich-Cole, Vivek Anantharaman, Thomas F. McCutchan, Sheldon L. Morris, Timothy G. Myers, Yamei Gao
Publikováno v:
The Journal of Infectious Diseases. 207:164-174
Exposure to ionizing radiation has a profound effect on the viability and further replication of living cells. Radiation is used for the treatment of cancer [1], generation of attenuated vaccines [2], and in food safety [3]. Radiation attenuation has
Autor:
Marcela Parra, Steven C. Derrick, Thomas E. Schmidt, Scott Stibitz, Sheldon L. Morris, Amy Li Yang
Publikováno v:
Journal of microbiological methods. 131
We describe a simplified Mycobacterial Growth Inhibition Assay (MGIA) for pre-clinical assessment of vaccine-mediated protection in mice. The assay is accomplished by directly infecting splenocytes from vaccinated mice with Mycobacterium tuberculosis