Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Sheldon I, Bastacky"'
Autor:
Yuan Gui, Zachary Palanza, Priya Gupta, Hanwen Li, Yuchen Pan, Yuanyuan Wang, Geneva Hargis, Donald L. Kreutzer, Yanlin Wang, Sheldon I. Bastacky, Yansheng Liu, Silvia Liu, Dong Zhou
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Calponin 2 (CNN2) is a prominent actin stabilizer. It regulates fatty acid oxidation (FAO) by interacting with estrogen receptor 2 (ESR2) to determine kidney fibrosis. However, whether CNN2 is actively involved in acute kidney injury (AKI) remains un
Externí odkaz:
https://doaj.org/article/89a91b5427e944aca05e4221d3e41fc1
Autor:
Yuan Gui, Yuanyuan Wang, Zachary Palanza, Jack L. Wang, Priya Gupta, Jianling Tao, Yi Qiao, Geneva Hargis, Donald L. Kreutzer, Sheldon I. Bastacky, Yanbao Yu, Yanlin Wang, Silvia Liu, Haiyan Fu, Dong Zhou
Publikováno v:
Molecular Metabolism, Vol 71, Iss , Pp 101712- (2023)
Objective: In the fibrotic kidneys, the extent of a formed deleterious microenvironment is determined by cellular mechanical forces. This process requires metabolism for energy. However, how cellular mechanics and metabolism are connected remains unc
Externí odkaz:
https://doaj.org/article/05b3c0860c704916a5a51e4d418d155b
Autor:
Russell C. Levack, Krista L. Newell, Berenice Cabrera-Martinez, Justin Cox, Andras Perl, Sheldon I. Bastacky, Gary M. Winslow
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
CD11c+T-bet+ B cells have been linked with different autoimmune diseases, but targeting these cells has been challenging. Here the authors use an adenosine 2A receptor agonist to deplete these B cells and to inhibit or reverse autoimmune symptoms and
Externí odkaz:
https://doaj.org/article/ad1d117384734ced8d0988ad19e62902
Autor:
Rachael A. Gordon, Christina Giannouli, Chirag Raparia, Sheldon I. Bastacky, Anthony Marinov, William Hawse, Richard Cattley, Jeremy S. Tilstra, Allison M. Campbell, Kevin M. Nickerson, Anne Davidson, Mark J. Shlomchik
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
NADPH oxidase deficiency exacerbates lupus in murine models and patients, but the mechanisms remain unknown. It is hypothesized that NADPH oxidase suppresses autoimmunity by facilitating dead cell clearance via LC3-associated phagocytosis (LAP). The
Externí odkaz:
https://doaj.org/article/3c1ff191a0484eb9a817b3dcb6dde47f
Publikováno v:
Molecular Metabolism, Vol 30, Iss , Pp 250-263 (2019)
Background: Globally, diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. As the most common microvascular complication of diabetes, DKD is a thorny, clinical problem in terms of its diagnosis and management. Intensive gluc
Externí odkaz:
https://doaj.org/article/3eab4f66b6c842b5a5fa934fa113e03f
Autor:
Nicolas Montalbetti, Sean D. Stocker, Gerard Apodaca, Sheldon I. Bastacky, Marcelo D. Carattino
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract The internal surface of the bladder is lined by the urothelium, a stratified epithelium that forms an impermeable barrier to water and urine constituents. Abnormalities in the urothelial barrier have been described in certain forms of cystit
Externí odkaz:
https://doaj.org/article/37f638bb0a6c47c0b7dd1aa3bab6b25c
Autor:
Rachael A Gordon, Jeremy S Tilstra, Anthony Marinov, Kevin M Nickerson, Sheldon I Bastacky, Mark J Shlomchik
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0226396 (2020)
Loss of tolerance to nuclear antigens and multisystem tissue destruction is a hallmark of systemic lupus erythematosus (SLE). Although the source of autoantigen in lupus remains elusive, a compelling hypothetical source is dead cell debris that drive
Externí odkaz:
https://doaj.org/article/85e463fd0b2544e280c52de750b2e124
Publikováno v:
Human Pathology: Case Reports, Vol 10, Iss , Pp 5-9 (2017)
Non-urothelial tumors of the urinary bladder are rare. Sarcomas constitute less than 1% of all malignant neoplasms and angiosarcomas comprise 2% of all sarcomas [1]. We report a case of a 69-year old male with history of a low-grade prostatic adenoca
Externí odkaz:
https://doaj.org/article/bd02d1fcabfc4523a82ee8644eb15480
Autor:
Dong Zhou, Yuanyuan Wang, Yuan Gui, Haiyan Fu, Shanshan Zhou, Yanlin Wang, Sheldon I. Bastacky, Donna B. Stolz, Youhua Liu
Publikováno v:
Kidney Int
Activation of canonical Wnt signaling has been implicated in podocyte injury and proteinuria. As Wnts are secreted proteins, whether Wnts derived from podocytes are obligatory for promoting proteinuria remains unknown. To address this, we generated c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d76ad3b3d1e7f91a33d1ccc1b00ec39
https://doi.org/10.1016/j.kint.2022.02.029
https://doi.org/10.1016/j.kint.2022.02.029
Bladder infection with uropathogenic Escherichia coli increases the excitability of afferent neurons
Autor:
Marcelo D. Carattino, Nicolas Montalbetti, Dennis R. Clayton, Sheldon I. Bastacky, Wily G. Ruiz, Marianela G. Dalghi, Gerard Apodaca
Publikováno v:
American Journal of Physiology-Renal Physiology. 322:F1-F13
Urinary tract infections (UTIs) cause bladder hyperactivity and pelvic pain, but the underlying causes of these symptoms remain unknown. We investigated whether afferent sensitization contributes to the bladder overactivity and pain observed in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03d0938ba9ae83641326b328d91bbad6
https://doi.org/10.1152/ajprenal.00167.2021
https://doi.org/10.1152/ajprenal.00167.2021